The DOI matches its Crossref record.
Mucin degradation in the human gastrointestinal tract and its significance to enteric microbial ecology
Abstract
Degradation of the gut mucus gel layer involves the combined actions of enteric bacterial glycosidases and esterases as well as host and microbial proteinases. Degradation of the carbohydrate chains of mucin glycoproteins involves glycosidases and glycosulfatases produced by specialized strains of normal enteric bacteria, resulting in the release of component monosaccharides which can be used as a source of nutrition by other, larger populations. Such functional specialization provides an ecological niche for enzyme-producing specialists and is likely to be a contributing factor to microbial diversity in enteric bacterial ecosystems.
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Microbial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012
“Also of interest is evidence from humans that resident mucolytic bacteria may differ among individuals according to the specific carbohydrate composition of intestinal mucins (eg, terminal sugars or branching patterns), which appears to vary by genetic background (117, 118).”
BackgroundMolecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859
“The resulting monoand disaccharides are utilized by larger fecal populations that cannot degrade these chains (16).”
BackgroundFlint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01281.x · Cited by 632
“, 2007) and degradation of mucin (Hoskins, 1993) but the phylogenetic distribution of these attributes is not yet fully established.”
BackgroundMucins: A biologically relevant glycan barrier in mucosal protection
Corfield, A. P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.003 · Cited by 590
“Experimentationwith isolated humanmucin oligosaccharide degrader (MOD) faecal bacterial strains, from individuals with different blood groups shows typical enzymatic activity for each blood group [106,143,150,210,211].”
Background
Metadata
- Authors
- Hoskins, L. C.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Hoskins, Lansing C.
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 1993-04
- Volume
- 5
- Issue
- 4
- Pages
- 205-213
- ISSN
- 0954-691X (ISSN-L)
- OpenAlex
- W1963985806
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 1 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 8 · 2013: 1 · 2012: 2
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Gastroenterology & Hepatology (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Digestive system and related health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- mucin degradation, enteric bacteria, glycoside hydrolases, esterase, proteolytic enzymes, mucin glycoproteins, microbial ecology, ecological niche, microbial diversity, human gastrointestinal tract
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