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Mucin degradation in the human gastrointestinal tract and its significance to enteric microbial ecology
Abstract
Degradation of the gut mucus gel layer involves the combined actions of enteric bacterial glycosidases and esterases as well as host and microbial proteinases. Degradation of the carbohydrate chains of mucin glycoproteins involves glycosidases and glycosulfatases produced by specialized strains of normal enteric bacteria, resulting in the release of component monosaccharides which can be used as a source of nutrition by other, larger populations. Such functional specialization provides an ecological niche for enzyme-producing specialists and is likely to be a contributing factor to microbial diversity in enteric bacterial ecosystems.
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Microbial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331
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“Also of interest is evidence from humans that resident mucolytic bacteria may differ among individuals according to the specific carbohydrate composition of intestinal mucins (eg, terminal sugars or branching patterns), which appears to vary by genetic background (117, 118).”
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“microflora (Corfield et al., 1992, 1993; Hoskins, 1993).”
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Ward, R. E., German, J. B., & Corredig, M. (2007) · Springer eBooks · doi:10.1007/0-387-28813-9_6 · Cited by 46
“The degradation of mucins requires the concerted action of proteases, esterases, sulfatases and glycosidases ( Hoskins, 1992 ).”
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Anti-cancer Substances and Safety of Lactic Acid Bacteria in Clinical Treatment
Liu, C., Zheng, J., Ou, X., & Han, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.722052 · Cited by 42
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BackgroundEDITORIAL. p53—INTEGRATING THE COMPLEXITY
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Immunodiscrimination of Colorectal Neoplasia Using MUC1 Antibodies:
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“이는 뮤신을 분해하여 단쇄지방산을 생성하는 것으로 알려져 있으며, species에 따라 다른 것으로 보 고되어있다[27].”
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Physiology of Enterococcus faecalis and faecium
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Composition and Function of the Human Gut Microbiome
Hitch, T. C. A., & Clavel, T. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_2
Speare, R. M. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metadata
- Authors
- Hoskins, L. C.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Hoskins, Lansing C.
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 1993-04
- Volume
- 5
- Issue
- 4
- Pages
- 205-213
- ISSN
- 0954-691X (ISSN-L)
- OpenAlex
- W1963985806
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 1 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 8 · 2013: 1 · 2012: 2
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Gastroenterology & Hepatology (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Digestive system and related health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- mucin degradation, enteric bacteria, glycoside hydrolases, esterase, proteolytic enzymes, mucin glycoproteins, microbial ecology, ecological niche, microbial diversity, human gastrointestinal tract
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