Autonomic response to standardized stress predicts subsequent disease activity in ulcerative colitis
Abstract
OBJECTIVES: Prospective studies of the role of psychological stress in ulcerative colitis are inconsistent or show a modest relationship. We tested the hypothesis that individual differences in autonomic function are associated with differences in the disease course of ulcerative colitis. METHODS: The spectral power of heart rate variability, an indirect marker of autonomic function, was measured during a standardized stress protocol in 93 ulcerative colitis patients. Patients were categorized as typical or atypical by an increase or decrease, respectively, in the high frequency band of heart rate variability from a period of acute stress to recovery 5 min later. Disease activity was measured at baseline (time 1) and a second time point (time 2) 7-37 months later. RESULTS: An atypical pattern of heart rate variability at time 1, present in 29% of patients, was associated with lower mean disease activity at time 2 (atypical, 0.56+/-0.93; typical, 2.27+/-2.56, P=0.001). The contribution of heart rate variability pattern to explaining time 2 disease activity was independent of the contributions of other factors that differed between groups, including time 1 disease activity and lifetime corticosteroid use. DISCUSSION: An atypical pattern of autonomic reactivity may be a marker of individual differences in stress regulation that has prognostic significance in ulcerative colitis.
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An experimental study found stress reactivity preceded a lower probability of disease exacerbation in the following 7-37 months.
“an experimental study found stress reactivity preceded a lower probability of disease exacerbation in the following 7–37 months. 48”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [48]
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- Authors
- Maunder, R. G., Greenberg, G. R., Nolan, R. P., Lancee, W. J., Steinhart, A. H., & Hunter, J. J.
- Affiliations
- Mount Sinai Hospital (CA)
- University Health Network (CA)
- University of Toronto (CA)
- Corresponding author
- Maunder, Robert G.
- Venue
- European Journal of Gastroenterology & Hepatology
- Published
- 2006-04
- Volume
- 18
- Issue
- 4
- Pages
- 413-420
- ISSN
- 0954-691X (ISSN-L)
- OpenAlex
- W2042628199
- Cited by
- 26
- References
- 24
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (43985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- ulcerative colitis, autonomic nervous system, heart rate variability, psychological stress, disease activity, stress reactivity, high-frequency band, prognosis, corticosteroid use, individual differences
- MeSH terms
- Adult, Autonomic Nervous System, Colitis, Ulcerative, Female, Heart Rate, Humans, Male, Middle Aged, Prospective Studies, Stress, Psychological
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