Stress-related peripheral neuroendocrine–immune interactions in women with ulcerative colitis
Abstract
Objectives The mechanisms underlying the interaction of psychological stress with the disease course in inflammatory bowel diseases remain unclear. We analyzed the neuroendocrine and cellular immune responses to public speaking stress, and the in vitro adrenergic and glucocorticoid modulation of cytokine production by peripheral blood cells (PBCs) in women with ulcerative colitis (UC) compared to healthy female controls.Methods In 22 female UC patients with inactive disease or mild disease activity and 24 healthy females we analyzed the neuroendocrine and cellular immune responses to public speaking stress and the vitro beta-adrenergic and glucocorticoid regulation of IL-10 and TNF-alpha production by PBCs.Results Public speaking stress-induced neuroendocrine and sympatho-adrenal activation, as well as the redistribution of circulating leukocytes were comparable in UC and controls. Significant but comparable public speaking stress-induced increases in LPS-stimulated TNF-alpha and IL-10, as well as in CD2/CD28-stimulated IFN-gamma were observed in both groups. UC demonstrated significantly reduced baseline IFN-gamma production, as well as significantly lower basal cortisol and prolactin levels. The in vitro beta-adrenergic stimulation of PBCs revealed reduced IL-10 response in UC.Conclusions Psychosocial stress-induced activation of the neuroendocrine and sympatho-adrenal systems remain unaltered in UC, suggesting that the mechanism(s) mediating effects of psychological stress on disease activity are likely operative downstream at the level of the intestine. However, UC patients show disturbances in basal endocrine and cytokine measures. Together with our in vitro evidence of disturbed adrenergic regulation of IL-10 production by stimulated PBCs in UC, these may indicate the existence of subtle disturbance of peripheral cellular neuroendocrine-immune interactions in UC.
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The proportion of female participants ranged from 36% to 83%, except in one study which had an exclusively female sample.
“The proportion of female participants ranged from 36% to 83%, except in one study, 43 which had an exclusively female sample”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [43]
Stress reactivity had no significant association with neuroendocrine-immune interactions.
“Another study found stress reactivity (measured using blood samples) had no significant association with neuroendocrine–immune interactions. 43”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [43]
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Self-citation
- Authors
- Langhorst, J., Cobelens, P. M., Kavelaars, A., Heijnen, C. J., Benson, S., Rifaie, N., Dobos, G. J., Schedlowski, M., & Elsenbruch, S.
- Affiliations
- Kliniken Essen-Mitte (DE)
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 32
- Issue
- 8-10
- Pages
- 1086-1096
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2159068998
- Cited by
- 35
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universitätsklinikum Essen
- Deutsche Forschungsgemeinschaft
- Deutsche Morbus Crohn/Colitis Ulcerosa Vereinigung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ulcerative colitis, psychological stress, neuroendocrine-immune interaction, public speaking stress, beta-adrenergic regulation, glucocorticoid regulation, cytokine production, IL-10, TNF-α, interferon-gamma, cortisol, prolactin, women, inflammatory bowel disease
- MeSH terms
- Adolescent, Adult, Cells, Cultured, Colitis, Ulcerative, Dexamethasone, Erythrocytes, Female, Glucocorticoids, Humans, Immune System, Lymphocytes, Middle Aged, Neuropsychological Tests, Neurosecretory Systems, Speech, Stress, Psychological, Sympathomimetics, Terbutaline, Lymphocyte Count
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