Expression of Protease-Activated Receptor 2 in Ulcerative Colitis

Proteinase-activated Receptors

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Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

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Proteinase-activated receptors: novel mechanisms of signaling by serine proteases

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Glutamine and glutamate—their central role in cell metabolism and function

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Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

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Protease-activated receptors in inflammation, neuronal signaling and pain

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Characterization of Protease-activated Receptor-2 Immunoreactivity in Normal Human Tissues

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Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice

Lindner, J. R., Kahn, M. L., Coughlin, S. R., Sambrano, G. R., Schauble, E. H., Bernstein, D., Foy, D., Hafezi‐Moghadam, A., & Ley, K. F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6504 · Cited by 274

Proteinase-Activated Receptor-2-Activating Peptides Induce Leukocyte Rolling, Adhesion, and Extravasation In Vivo

Vergnolle, N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.5064 · Cited by 225

Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by histamine

He, S., Peng, Q., & Walls, A. F. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.6216 · Cited by 216

Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

Fiorucci, S., Mencarelli, A., Palazzetti, B., Distrutti, E., Vergnolle, N., Hollenberg, M. D., Wallace, J. L., Morelli, A., & Cirino, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241377298 · Cited by 195

The Role of Mast Cell Tryptase in Regulating Endothelial Cell Proliferation, Cytokine Release, and Adhesion Molecule Expression: Tryptase Induces Expression of mRNA for IL-1β and IL-8 and Stimulates the Selective Release of IL-8 from Human Umbilical Vein Endothelial Cells

Compton, S. J., Cairns, J. A., Holgate, S. T., & Walls, A. F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1939 · Cited by 189

The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells.

Compton, S. J., Cairns, J. A., Holgate, S. T., & Walls, A. F. (1998) · PubMed · Cited by 171

Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle

Al‐Ani, B., Saifeddine, M., & Hollenberg, M. D. (1995) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y95-172 · Cited by 161

Mast cells are an important cellular source of tumour necrosis factor α in human intestinal tissue

Bischoff, S. C., Lorentz, A., Schwengberg, S., Weier, G., Raab, R., & Manns, M. P. (1999) · Gut · doi:10.1136/gut.44.5.643 · Cited by 158

Proteinase-activated receptor-2: expression by human neutrophils

Howells, G. L., Macey, M. G., Chinni, C., Hou, L., Fox, M. T., Harriott, P., & Stone, S. R. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.7.881 · Cited by 158

Trypsin Induces Activation and Inflammatory Mediator Release from Human Eosinophils Through Protease-Activated Receptor-2

Miike, S., McWilliam, A. S., & Kita, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6615 · Cited by 154

Release of Mast Cell Tryptase from Human Colorectal Mucosa in Inflammatory Bowel Disease

Raithel, M., Winterkamp, S., Pacurar, A., Ulrich, P. M., Hochberger, J., & Hahn, E. G. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655201750065933 · Cited by 153

A Role for Tryptase in the Activation of Human Mast Cells: Modulation of Histamine Release by Tryptase and Inhibitors of Tryptase

He, S., Gaça, M., & Walls, A. F. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37586-x · Cited by 151

Increased expression of IL-16 in inflammatory bowel disease

Seegert, D., Rosenstiel, P. C., Pfahler, H., Pfefferkorn, P., Nikolaus, S., & Schreiber, S. (2001) · Gut · doi:10.1136/gut.48.3.326 · Cited by 133

Localization of Protease-Activated Receptors -1 and -2 in Human Mast Cells: Indications for an Amplified Mast Cell Degranulation Cascade

D’Andrea, M. R., Rogahn, C. J., & Andrade‐Gordon, P. (2000) · Biotechnic & Histochemistry · doi:10.3109/10520290009064152 · Cited by 124

Immunolocalization of protease‐activated receptor‐2 in skin: receptor activation stimulates interleukin‐8 secretion by keratinocytes in vitro

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Allergy and the Gut

Bischoff, S. C., Mayer, J. H., & Manns, M. P. (2000) · International Archives of Allergy and Immunology · doi:10.1159/000024340 · Cited by 118

Increased vascular permeability by a specific agonist of protease‐activated receptor‐2 in rat hindpaw

Kawabata, A., Kuroda, R., Minami, T., Kataoka, K., & Taneda, M. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702063 · Cited by 118

Immune mechanisms in chronic inflammatory bowel disease.

Braegger, C., & MacDonald, T. T. (1994) · PubMed · Cited by 109

Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient Ws/Ws rats

Araki, Y., Andoh, A., Fujiyama, Y., & Bamba, T. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01094.x · Cited by 85

Trypsin induces tumour necrosis factor‐α secretion from a human leukemic mast cell line

Kang, O., Jeong, H., Kim, D., Choi, S. C., Kim, T. H., Nah, Y., Kim, H., & Lee, Y. (2003) · Cell Biochemistry and Function · doi:10.1002/cbf.1014 · Cited by 26

Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes

Greenfeder, S. A., Sehring, S., McHugh, N. A., Corboz, M. R., Rivelli, M. A., Anthes, J. C., Billah, M. M., Egan, R. W., & Chapman, R. W. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00960-8 · Cited by 8

Important antinutrients in plant feedstuffs for aquaculture: an update on recent findings regarding responses in salmonids

Krogdahl, Å., Penn, M. H., Thorsen, J., Refstie, S., & Bakke, A. M. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2009.02426.x · Cited by 605

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591

Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response

Steinhoff, M. S., Buddenkotte, J., Shpacovitch, V. M., Rattenholl, A., Moormann, C., Vergnolle, N., Luger, T. A., & Hollenberg, M. D. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0025 · Cited by 501

Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases

Sturgeon, C., & Fasano, A. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1251384 · Cited by 497

Key role of mast cells and their major secretory products in inflammatory bowel disease

He, S. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i3.309 · Cited by 264

Increased expression of protease-activated receptor-2 in mucosal mast cells in Crohn's ileitis

Christerson, U., Keita, Å. V., Söderholm, J. D., & Gustafson‐Svärd, C. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2008.11.003 · Cited by 15

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.

Cénac, N., Coelho, A., Nguyen, C., Compton, S., Andrade-Gordon, P., MacNaughton, W., Wallace, J., Hollenberg, M., Bunnett, N., Garcia-Villar, R., et al. (2002) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64466-5 · Cited by 386

Activation of human colon mast cells through proteinase activated receptor-2

Shao-HengHe, Yong-SongHe, & HuaXie (2004) · World Journal of Gastroenterology

Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC)

Tahara, T., Shibata, T., Nakamura, M., Yamashita, H., Yoshioka, D., Okubo, M., Maruyama, N., Kamano, T., Kamiya, Y., Fujita, H., et al. (2009) · Clinical and Experimental Medicine · doi:10.1007/s10238-008-0025-x · Cited by 43

Bcl2L12 mediates effects of protease-activated receptor-2 on the pathogenesis of Th2-dominated responses of patients with ulcerative colitis

Feng, B., Wu, Y., Zeng, X., Yu, D., Liu, Z., Zhou, C.-J., Liu, Z., Zheng, P., & Yang, P. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.09.003 · Cited by 8