The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Expression of Protease-Activated Receptor 2 in Ulcerative Colitis
Abstract
Although tryptase released from mast cells might play a key role in the pathogenesis of ulcerative colitis (UC), the role of protease-activated receptor 2 (PAR2), tryptase receptor, remains unclear in the pathogenesis of this disease. The expressions of PAR2 and tumor necrosis factor (TNF) alpha in nine UC tissues and nine normal tissues were examined by immunohistochemistry. TNF-alpha levels secreted from human leukemic mast cell line (HMC-1) after the treatment of PAR2 agonists were also measured by enzyme-linked immunosorbent assay. The PAR2 and TNF-alpha proteins were more significantly detectable in UC tissues than in normal tissues. Furthermore, 65.2% of PAR2+ cells and 66.4% of TNF-alpha+ cells in UC tissues were tryptase-positive cells. In other words, 60.6% and 46.3% of tryptase-positive cells in UC tissues were PAR2+ cells and TNF-alpha+ cells, respectively. A chi2 analysis showed correlation (p < 0.007) between PAR2 and TNF-alpha in tryptase-positive mast cells. Moreover, PAR2 agonists significantly induced the TNF-alpha secretion from HMC-1. These results indicate that the activation of the mast cells through PAR2 may be involved in the pathogenesis of UC.
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“Moreover, elevated expression of par2 in the colon tissue of patients with UC has been described. 142”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [142]
Citations
Cites
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Krogdahl, Å., Penn, M. H., Thorsen, J., Refstie, S., & Bakke, A. M. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2009.02426.x · Cited by 605
Role for protease activity in visceral pain in irritable bowel syndrome
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Metadata
- Authors
- Kim, J.-A., Choi, S.-C., Yun, K.-J., Kim, D.-K., Han, M.-K., Seo, G.-S., Yeom, J.-J., Kim, T.-H., Nah, Y.-H., & Lee, Y.-M.
- Affiliations
- Wonkwang University (KR)
- Jeonbuk National University (KR)
- Corresponding author
- Han, Myung-Kwan
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-07
- Volume
- 9
- Issue
- 4
- Pages
- 224-229
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2065903707
- Cited by
- 96
- References
- 29
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 9 · 2013: 1 · 2012: 4
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- protease-activated receptor 2, ulcerative colitis
- MeSH terms
- Colitis, Ulcerative, Gene Expression Regulation, Humans, Immunohistochemistry, Leukemia, Macrophages, Mast Cells, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Receptors, Thrombin, Receptor, PAR-2
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