Cited by 96Inflammatory Bowel DiseaseMast cells and histamineProtease and Inhibitor Mechanisms

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Expression of Protease-Activated Receptor 2 in Ulcerative Colitis

Kim, Jin-A, Choi, Suck-Chei, Yun, Ki-Jung, Kim, Dae-Ki, Han, Myung-Kwan, Seo, Geom-Seog, Yeom, Ju-Jin, Kim, Tae-Hyun, Nah, Yong-Ho, Lee, Young-Mi·2003·Inflammatory Bowel Diseases

DOI 10.1097/00054725-200307000-00002

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Abstract

Although tryptase released from mast cells might play a key role in the pathogenesis of ulcerative colitis (UC), the role of protease-activated receptor 2 (PAR2), tryptase receptor, remains unclear in the pathogenesis of this disease. The expressions of PAR2 and tumor necrosis factor (TNF) alpha in nine UC tissues and nine normal tissues were examined by immunohistochemistry. TNF-alpha levels secreted from human leukemic mast cell line (HMC-1) after the treatment of PAR2 agonists were also measured by enzyme-linked immunosorbent assay. The PAR2 and TNF-alpha proteins were more significantly detectable in UC tissues than in normal tissues. Furthermore, 65.2% of PAR2+ cells and 66.4% of TNF-alpha+ cells in UC tissues were tryptase-positive cells. In other words, 60.6% and 46.3% of tryptase-positive cells in UC tissues were PAR2+ cells and TNF-alpha+ cells, respectively. A chi2 analysis showed correlation (p < 0.007) between PAR2 and TNF-alpha in tryptase-positive mast cells. Moreover, PAR2 agonists significantly induced the TNF-alpha secretion from HMC-1. These results indicate that the activation of the mast cells through PAR2 may be involved in the pathogenesis of UC.

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Authors: Kim, J.-A., Choi, S.-C., Yun, K.-J., Kim, D.-K., Han, M.-K., Seo, G.-S., Yeom, J.-J., Kim, T.-H., Nah, Y.-H., & Lee, Y.-M.
Affiliations: Wonkwang University (KR)
Jeonbuk National University (KR)
Corresponding author: Han, Myung-Kwan
ORCID: Han, Myung-Kwan
Seo, Geom-Seog
Kim, Tae-Hyun
Lee, Young-Mi
Venue: Inflammatory Bowel Diseases
Publisher: Oxford University Press (OUP)
Published: 2003-07
Volume: 9
Issue: 4
Pages: 224-229
ISSN: 1078-0998 (ISSN-L)
DOI: 10.1097/00054725-200307000-00002
OpenAlex: W2065903707
Cited by: 96
References: 29
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 9 · 2013: 1 · 2012: 4
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Locations: Inflammatory Bowel Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: protease-activated receptor 2, ulcerative colitis
MeSH terms: Colitis, Ulcerative, Gene Expression Regulation, Humans, Immunohistochemistry, Leukemia, Macrophages, Mast Cells, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Receptors, Thrombin, Receptor, PAR-2

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Expression of Protease-Activated Receptor 2 in Ulcerative Colitis

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