Cited by 108Muscle metabolism and nutritionClinical Nutrition and GastroenterologyNutrition and Health in Aging

Regulation of skeletal muscle protein metabolism in catabolic states

Wolfe, Robert R·2005·Current Opinion in Clinical Nutrition and Metabolic Care

Abstract

PURPOSE OF REVIEW: This review highlights recent publications dealing with the nature of the in-vivo response of skeletal muscle to critical illness and approaches to attenuating this response. Studies focused on molecular mechanisms of muscle catabolism are not reviewed. RECENT FINDINGS: The general areas covered are the metabolic response to stress, particularly regarding the relationship between muscle protein breakdown, amino acid availability, and muscle protein synthesis. The impact of the profile of amino acids in the context of protein/amino acid intake is also discussed. Advances in our understanding of the hormonal response are considered, and use of insulin therapy to slow muscle catabolism is discussed. SUMMARY: Muscle catabolism is a fundamental response to severe stress, and the resulting amino acid efflux from muscle provides important precursors for protein synthesis in other parts of the body. The nature of this response (i.e. transport kinetics favoring efflux of amino acids from muscle) makes amelioration of the catabolic response of muscle with nutrition alone very difficult. Many approaches have been used to reverse catabolism, mostly involving various anabolic hormones. Recent studies using insulin therapy are particularly intriguing because of the low cost and powerful anabolic stimulus of insulin.

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Registry

Crossref · 10.1097/00075197-200501000-00009

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33 of 33 references verified0 citation errors · 0 not checkable

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  • Muscle cells benefit from this response despite net catabolism of muscle mass.

    “Simultaneously, muscle cells benefit from this response despite net catabolism of muscle mass.89, 90”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [89]

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Authors
Wolfe, R. R.
Affiliations
The University of Texas Medical Branch at Galveston (US)
Corresponding author
Wolfe, Robert R
Venue
Current Opinion in Clinical Nutrition and Metabolic Care
Published
2005-01
Volume
8
Issue
1
Pages
61-65
ISSN
1363-1950 (ISSN-L)
OpenAlex
W2016803694
Cited by
108
References
33
Citations by year
2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 12 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 11 · 2013: 1 · 2012: 9
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
skeletal muscle protein metabolism, muscle catabolism, critical illness, amino acid availability, muscle protein synthesis, amino acid efflux, insulin therapy, anabolic hormones, stress response, nutritional support, catabolic state
MeSH terms
Amino Acids, Humans, Insulin, Muscle Proteins, Stress, Physiological, Muscle, Skeletal

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