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Cited by 138Heart Rate Variability and Autonomic ControlSepsis Diagnosis and TreatmentHemodynamic Monitoring and Therapy

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Autonomic dysfunction in the ICU patient

Schmidt, Hendrik B., Werdan, Karl, Müller-Werdan, Ursula·2001·Current Opinion in Critical Care
DOI 10.1097/00075198-200110000-00002
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Abstract

The sympathetic-parasympathetic balance may be altered in critically ill patients. Assessment of autonomic function provides information concerning prognosis, pathogenesis, and treatment strategies in ICU-relevant disorders. Proven tools are heart rate variability, baroreflex sensitivity, and, with limitations, cardiac chemoreflex sensitivity. New nonlinear methods are being evaluated that may predict risk more precisely in critically ill patients. This article summarizes application of these tools in the ICU. In addition, a model is introduced for investigating the impaired autonomic function in multiple organ dysfunction syndrome and sepsis, integrating extrinsic mechanisms and factors that are intrinsic to the cardiac tissue. By this combined approach, the authors hope to gain insight into the pathogenesis of multiple organ dysfunction syndrome. New pathophysiologic concepts are needed for the development of treatment strategies for this life-threatening disease.

Overview

Integrity signals

Registry

Crossref · 10.1097/00075198-200110000-00002

Cites

42 of 42 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • Patients with sepsis and organ failure have depressed vagus nerve activity.

    “Cholinergic and anticholinergic drugs are also widely used in intensive care units, where patients with sepsis and organ failure have increased cytokine levels and depressed vagus nerve activity (55,56,(81)(82)(83).”

    From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [81]

  • Patients with sepsis and organ failure have increased cytokine levels.

    “Cholinergic and anticholinergic drugs are also widely used in intensive care units, where patients with sepsis and organ failure have increased cytokine levels and depressed vagus nerve activity (55,56,(81)(82)(83).”

    From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [81]

Citations

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Research works printed but not linked: 1

  1. M??ller-Werdan, 1998, Eur Cytokine Netw, 9, 689

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Metadata

Authors
Schmidt, H. B., Werdan, K., & Müller-Werdan, U.
Affiliations
Martin Luther University Halle-Wittenberg (DE)
Corresponding author
Werdan, Karl
ORCID
Werdan, Karl
Venue
Current Opinion in Critical Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-10
Volume
7
Issue
5
Pages
314-322
ISSN
1070-5295 (ISSN-L)
DOI
10.1097/00075198-200110000-00002
OpenAlex
W2018366225
Cited by
138
References
42
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 10
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Critical Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords
autonomic dysfunction, critically ill patients, heart rate variability, baroreflex sensitivity, nonlinear methods, multiple organ failure, sepsis, sympathetic and parasympathetic balance, prognosis
MeSH terms
Autonomic Nervous System, Autonomic Nervous System Diseases, Cardiovascular System, Heart Rate, Humans, Intensive Care Units, Multiple Organ Failure, Respiratory System, Critical Illness, Baroreflex

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