Attenuation of ECS-Induced Retrograde Amnesia by Using an Herbal Formulation
Abstract
Earlier research indicated the efficacy of a complex herbal formulation in the attenuation of electroconvulsive shock (ECS)-induced amnestic deficits in rats; this study sought to ascertain whether a simplified herbal formulation (Memorin; Phyto-Pharma, India) also was effective. Rats pretreated for a fortnight with Memorin (200 mg/kg/day) or vehicle were exposed to a passive-avoidance learning paradigm in a shuttle box. The next day, the rats were administered two true or sham ECSs, 5 h apart; recall of the pre-ECS learning was reassessed on the following day. ECS was found to produce significant retrograde amnesia (p < 0.002). Memorin attenuated the ECS-induced amnesia (p = 0.00003) without influencing the ECS seizure duration. The clinical implications of these findings are discussed.
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Memorin (200 mg/day/kg) was found to attenuate retrograde and anterograde amnesia in rats when tested using passive avoidance learning paradigms in the shuttle box and T-maze test.
“Additionally, memorin (200 mg/day/kg) was found to attenuate retrograde and anterograde amnesia in rats when tested using passive avoidance learning paradigms in the shuttle box and T-maze test [257].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [257]
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Dahanukar, S., Kulkarni, A., & Rege, N. (2000) · Indian Journal of Pharmacology · Cited by 579 · see citing works
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Pharmacological Attenuation of Electroconvulsive Therapy-Induced Cognitive Deficits
Pigot, M., Andrade, C., & Loo, C. K. A. (2008) · Journal of Ect · doi:10.1097/yct.0b013e3181616c14 · Cited by 57 · see citing works
Self-citationPrakash, J., Kotwal, A., & Prabhu, H. (2006) · Journal of Ect · doi:10.1097/01.yct.0000230365.81368.2d · Cited by 49 · see citing works
“Memorin, a herbal formulation derived from Mandookaparni (Centella asiatica), Jatamansi (Nardostachys jatamansi), Yashtimadhu (Glycyrrhyza glabra), and Shankapushpi (Evolvulus alsinoides), also had benefits in animal models.(18) As ECT is associated with central nervous system cholinergic dysfunction,(19) we hypothesi…”
BackgroundAndrade, C., Sudha, S., & Venkataraman, B. V. (2000) · Journal of Ect · doi:10.1097/00124509-200006000-00006 · Cited by 29 · see citing works
“The administration of Memorin for 2 weeks attenuated retrograde amnesia, measured using the passive avoidance paradigm, in rats that received two ECS on the same day, spaced 5 hours apart (Vinekar et al., 1998).”
MethodSelf-citationGlucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia
Nagaraja, N., Andrade, C., Suresh, S., Singh, N. M., Chandra, J. S., & Venkataraman, B. V. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0593-y · Cited by 27 · see citing works
Self-citationAndrade, C. (2008) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.44745 · Cited by 24 · see citing works
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Sudha, S., Andrade, C., Anand, A., et al. (2001) · Journal of Ect · doi:10.1097/00124509-200103000-00008 · Cited by 15 · see citing works
Self-citationEffects of Stimulus Parameters on Seizure Duration and ECS-Induced Retrograde Amnesia
Andrade, C., Suresh, S., Krishnan, J., et al. (2002) · Journal of Ect · doi:10.1097/00124509-200203000-00010 · Cited by 11 · see citing works
“The procedure followed that which was established earlier (16).”
MethodResultSelf-citationPhenylephrine and ECS-Induced Retrograde Amnesia
Anand, A., Andrade, C., Sudha, S., et al. (2001) · Journal of Ect · doi:10.1097/00124509-200109000-00003 · Cited by 9 · see citing works
Self-citationAnti-amnestic properties of Brahmi and Mandookaparni in a rat model
Andrade, C., & Chandra, J. S. (2006) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.31554 · Cited by 8 · see citing works
Self-citationKaur, S., Singh, B., Singh, H. B., Singh, B., Kumar, N., Rajput, A., Sidhu, D., Kaur, A., & Arora, S. (2021) · Current Drug Delivery · doi:10.2174/1567201818666211015152733 · Cited by 7 · see citing works
Kognitive Störungen und Elektrokrampftherapie
Prapotnik, M., Pycha, R., Nemes, C., König, P., Hausmann, A., & Conca, A. (2006) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-005-0237-6 · Cited by 5 · see citing works
“Welche Bedeutung Kräuterextrakte dabei spielen ist weiterhin offen; tierexperimentelle und erste klinische Erfahrungen zeigen eine bestimmte, aber noch mit Vorsicht zu interpretierende nootropische Wirksamkeit [65, 66].”
BackgroundInfluentialChaudhury, S., Prakash, J., Chatterjee, K., et al. (2019) · Industrial Psychiatry Journal · doi:10.4103/ipj.ipj_105_20 · Cited by 1 · see citing works
“Both animal and human studies showed some prospect in this dimension but finding mostly were variable and lacked replication.[18-23] Drugs/ group of drugs tried so far are N-methyl-D-aspartate receptor antagonists, cyclooxygenase inhibitors, calcium channel blockers, cholinesterase inhibitors, glucocorticoid receptor…”
Background
- Authors
- Vinekar, A. S., Andrade, C., Sriprada, V. T., George, J., Joseph, T., & Chandra, J. S.
- Affiliations
- St.John's Medical College Hospital (IN)
- Venue
- The Journal of ECT
- Published
- 1998-06
- Volume
- 14
- Issue
- 2
- Pages
- 83???88
- ISSN
- 1095-0680 (ISSN-L)
- OpenAlex
- W1996058031
- Cited by
- 16
- References
- 0
- Citations by year
- 2021: 2 · 2020: 1 · 2019: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ect (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- electroconvulsive shock, retrograde amnesia, herbal formula, passive avoidance learning, memory retrieval, seizure duration, neuroprotection
- MeSH terms
- Amnesia, Animals, Anticonvulsants, Electroconvulsive Therapy, Male, Plant Extracts, Plants, Medicinal, Reaction Time, Time Factors, Rats, Sprague-Dawley, Rats
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