The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients
Abstract
BACKGROUND: We planned to analyze the prevalence and distribution of beta-amyloid deposition in the HIV+ brain in the HAART era. Our working hypothesis is that long term survival, aging and the secondary effects of HAART may contribute to increased beta-amyloid accumulation in this patient population. METHODS: Paraffin embedded archival brain autopsy tissues were assessed by immunocytochemistry for beta-amyloid. Detailed in-vivo neuro-behavioral assessments and ApoE genotyping were available for a subset of the studied population. RESULTS: Immunoreactivity with the antibodies 4G8 and 6E10 was found predominantly in neuronal soma and dystrophic axonal processes. Extracellular, often perivascular plaques were also identified in many cases. CONCLUSIONS: We propose that prolonged HAART and aging may contribute to an overall increase in amyloid deposition, potentially mediated by inhibition of insulin degradation enzyme (IDE) or disruption of the axonal transport of the amyloid precursor protein.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, brains from post‐mortem HIV patients display increased levels of deposited amyloid beta (Aβ) and hyperphosphorylated tau compared to age‐matched controls, suggesting pathological links exist between Alzheimer’s disease and HAD (Green et al, 2005; Anthony et al, 2006; Achim et al, 2009).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Green et al, 2005
Citations
Cites
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L., & Price, D. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1561 · Cited by 733
Lazarov, O., Lee, M., Peterson, D. A., & Sisodia, S. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09785.2002 · Cited by 302
Buxbaum, J. D., Thinakaran, G., Koliatsos, V. E., O’Callahan, J., Slunt, H. H., Price, D. L., & Sisodia, S. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09629.1998 · Cited by 266
Adle‐Biassette, Chrétien, Wingertsmann, Hery, H., Ereau, Scaravilli, Tardieu, & Gray (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00167.x · Cited by 233
Prevalence of Alzheimer plaques in AIDS
Esiri, M. M., Biddolph, S. C., & Morris, C. S. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.1.29 · Cited by 225
Glial Cytokines as Neuropathogenic Factors in HIV Infection
Stanley, L. C., Mrak, R. E., Woody, R. C., Perrot, L. J., Zhang, S., Marshak, D. R., Nelson, S. J., & Griffin, W. S. T. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199405000-00003 · Cited by 150
β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology
Pike, C. J., Cummings, B. J., & Cotman, C. W. (1992) · Neuroreport · doi:10.1097/00001756-199209000-00012 · Cited by 131
Masliah, E., Westland, C., Rockenstein, E. M., Abraham, C. R., Mallory, M. E., Veinberg, I., Sheldon, E., & Mucke, L. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00553-2 · Cited by 119
Self-citationAxonal Damage Revealed by Accumulation of β-APP in HIV-positive Individuals without AIDS
An, S., Giometto, B., Groves, M., Miller, R. F., Beckett, A. A. J., Gray, F., Tavolato, B. F., & Scaravilli, F. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199711000-00011 · Cited by 90
Ichihara, N., Wu, J., Hua Chui, D., Yamazaki, K., Wakabayashi, T., & Kikuchi, T. (1995) · Brain Research · doi:10.1016/0006-8993(95)00729-a · Cited by 70
Accumulation of β-Amyloid Precursor Protein in Axons Correlates with CNS Expression of SIV gp41
Mankowski, J. L., Queen, S. E., Tarwater, P. M., Fox, K., & Perry, V. H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.1.85 · Cited by 65
Expression of β-amyloid precursor protein in axons of periventricular leukomalacia brains
Arai, Y., Deguchi, K., Mizuguchi, M., & Takashima, S. (1995) · Pediatric Neurology · doi:10.1016/0887-8994(95)00149-a · Cited by 49
Iżycka‐Świeszewska, E., Żółtowska, A., Rzepko, R., Gross, M., & Borowska-Lehman, J. (2000) · PubMed · Cited by 39
Kása, P., Papp, H., Kovács, I., Forgon, M., Penke, B., & Yamaguchi, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00863-0 · Cited by 38
Central Nervous System Pathology in Pediatric AIDSa
Dickson, D. W., Llena, J. F., Nelson, S. J., & Weidenheim, K. M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26259.x · Cited by 29
Tissue Microarrays in the Study of Non-Neoplastic Disease of the Nervous System
Goldstine, J., Seligson, D. B., Beizai, P., Miyata, H., & Vinters, H. V. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.8.653 · Cited by 27
Self-citationOhgami, T., Kitamoto, T., Weidmann, A., Beyreuther, K. T., & Tateishi, J. (1991) · PubMed Central · Cited by 24
Cited by
Sorted by citations
Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
Tiwari, S., Atluri, V., Kaushik, A., Yndart, A., & Nair, M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200490 · Cited by 1,308
HIV-associated neurocognitive disorder
Clifford, D. B., & Ances, B. M. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70269-x · Cited by 698
Microbes and Alzheimer’s Disease
Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., Bullido, M. J., Carter, C., Clerici, M., Cosby, S. L., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160152 · Cited by 532
Kent, S. A., Spires-Jones, T. L., & Durrant, C. S. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02196-w · Cited by 446
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment
Eggers, C., Arendt, G., Hahn, K., Husstedt, I. W., Maschke, M., Neuen-Jacob, E., Obermann, M., Rosenkranz, T., Schielke, E., & Straube, E. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8503-2 · Cited by 338
Metadata
- Authors
- Green, D. A., Masliah, E., Vinters, H. V., Beizai, P., Moore, D. J., & Achim, C. L.
- Affiliations
- University of Pittsburgh (US)
- University of California San Diego (US)
- University of California, Los Angeles (US)
- Corresponding author
- Achim, Cristian L
- Venue
- AIDS
- Published
- 2005-03-04
- Volume
- 19
- Issue
- 4
- Pages
- 407-411
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2033154907
- Cited by
- 299
- References
- 17
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 20 · 2019: 25 · 2018: 19 · 2017: 19 · 2016: 16 · 2015: 9 · 2014: 24 · 2013: 17 · 2012: 7
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca035040-03, 5r01mh058528-05)
- National Institute on Aging (P50AG016570)
- National Institute of Mental Health (MH58528)
- National Institute of Allergy and Infectious Diseases (U01AI035040, U01 AI/CA 35040)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Keywords
- amyloid-beta deposition, HIV-associated neurocognitive disorders, HIV, highly active antiretroviral therapy, aging, amyloid plaques, APOE genotype, insulin-degrading enzyme, amyloid precursor protein, axonal transport
- MeSH terms
- Adult, Aged, Amyloidosis, Brain Diseases, Female, Humans, Male, Middle Aged, HIV Infections, Amyloid beta-Peptides, Paraffin Embedding, Antiretroviral Therapy, Highly Active
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
