β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

Pike, Christian J.; Cummings, Brian J.; Cotman, Carl W.

doi:10.1097/00001756-199209000-00012

Cited by 131Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

Pike, Christian J., Cummings, Brian J., Cotman, Carl W.·1992·Neuroreport

DOI 10.1097/00001756-199209000-00012

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Abstract

beta-Amyloid protein, the major component of neuritic plaques found in Alzheimer's disease, has been implicated as a potential contributor to the disease's progressive neuropathology. We report that within a two day exposure to aggregates of synthetic beta-amyloid peptide, the neurites of cultured rat hippocampal neurons adopt a dystrophic appearance. Observed morphological changes in the neurites include beading, fragmentation, terminal swelling and tortuous growth patterns. The degenerative changes are similar to those observed in neurites associated with neuritic plaques, suggesting that beta-amyloid may induce the neuritic abnormalities of Alzheimer neuropathology.

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Aβ plaques facilitate a positive feedback loop of increasing oxidative stress and elevated Aβ levels, leading to neuritic dystrophy and neuronal death.
“Aβ plaques also play a role in facilitating a positive feedback loop of increasing oxidative stress and subsequently elevated Aβ levels, leading to neuritic dystrophy and culminating in neuronal death [16,17,18,19].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [19]

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Authors: Pike, C. J., Cummings, B. J., & Cotman, C. W.
Affiliations: University of California, Irvine (US)
ORCID: Pike, Christian J.
Cummings, Brian J.
Cotman, Carl W.
Venue: Neuroreport
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1992-09
Volume: 3
Issue: 9
Pages: 769-772
ISSN: 0959-4965 (ISSN-L)
DOI: 10.1097/00001756-199209000-00012
OpenAlex: W2017132797
Cited by: 131
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 2
FWCI: 4.76
Type: journal article
Language: en
Open access: closed
Locations: Neuroreport (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r35ag007918-01)
National Institute on Aging (AG07918)
National Institute of Mental Health (MH 14599, T32MH014599)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: amyloid-beta, neuritic dystrophy, neurite degeneration, neuritic plaques, Alzheimer's disease, hippocampal neurons, neurite morphology, neurotoxicity
MeSH terms: Alzheimer Disease, Animals, Microscopy, Electron, Nerve Degeneration, Amyloid beta-Peptides, Neurites, Rats, Sprague-Dawley, Culture Techniques, Rats

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β-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology

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