The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Effects of Mild Perioperative Hypothermia on Blood Loss and Transfusion Requirement
Abstract
Background: Anesthetic-induced hypothermia is known to reduce platelet function and impair enzymes of the coagulation cascade. The objective of this meta-analysis and systematic review was to evaluate the hypothesis that mild perioperative hypothermia increases surgical blood loss and transfusion requirement. Methods: The authors conducted a systematic search of published randomized trials that compared blood loss and/or transfusion requirements in normothermic and mildly hypothermic (34-36 degrees C) surgical patients. Results are expressed as a ratio of the means or relative risks and 95% confidence intervals (CI); P < 0.05 was considered statistically significant. Results: Fourteen studies were included in analysis of blood loss, and 10 in the transfusion analysis. The median (quartiles) temperature difference between the normothermic and hypothermic patients among studies was 0.85 degrees C (0.60 degrees C versus 1.1 degrees C). The ratio of geometric means of total blood loss in the normothermic and hypothermic patients was 0.84 (0.74 versus 0.96), P = 0.009. Normothermia also reduced transfusion requirement, with an overall estimated relative risk of 0.78 (95% CI 0.63, 0.97), P = 0.027. Conclusion: Even mild hypothermia (<1 degree C) significantly increases blood loss by approximately 16% (4-26%) and increases the relative risk for transfusion by approximately 22% (3-37%). Maintaining perioperative normothermia reduces blood loss and transfusion requirement by clinically important amounts.
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Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Funnel plots for detecting bias in meta-analysis
Sterne, J. A. C., & Egger, M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00377-8 · Cited by 3,779
Greenland, S. (2001) · Biostatistics · doi:10.1093/biostatistics/2.4.463 · Cited by 359 · cited 1×
“A formal incorporation of the quality scores into our meta-analysis was not performed because of the problems with quality scores in general, including bias and subjectivity.(39) We did, however, assess whether there was an obvious correlation between the estimated treatment effects and the quality scores.”
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Cited by
Gustafsson, U. O., Scott, M. J., Hubner, M., Nygren, J., Demartines, N., Francis, N., Rockall, T. A., Young‐Fadok, T. M., Hill, A. G., Soop, M., et al. (2019) · World Journal of Surgery · doi:10.1007/s00268-018-4844-y · Cited by 2,119
Low, D. E., Allum, W., De Manzoni, G., Ferri, L., Immanuel, A., Kuppusamy, M., Law, S., Lindblad, M., Maynard, N., Neal, J., et al. (2019) · World Journal of Surgery · doi:10.1007/s00268-018-4786-4 · Cited by 641
Brown, D. J. A., Brugger, H., Boyd, J., & Paal, P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1114208 · Cited by 624
Exploiting the critical perioperative period to improve long-term cancer outcomes
Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487
Lassen, K., Coolsen, M. M. E., Slim, K., Carli, F., de Aguilar‐Nascimento, J. E., Schäfer, M., Parks, R. W., Fearon, K. C. H., Lobo, D. N., Demartines, N., et al. (2013) · World Journal of Surgery · doi:10.1007/s00268-012-1771-1 · Cited by 473
Metadata
- Authors
- Rajagopalan, S., Mascha, E., Na, J., & Sessler, D. I.
- Venue
- Anesthesiology
- Published
- 2008-01-01
- Volume
- 108
- Issue
- 1
- Pages
- 71-77
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2069668391
- Cited by
- 905
- References
- 3
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rajagopalan, S., Mascha, E., Na, J., & Sessler, D. I. (2008). The Effects of Mild Perioperative Hypothermia on Blood Loss and Transfusion Requirement. Anesthesiology. https://doi.org/10.1097/01.anes.0000296719.73450.52
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
