The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Efficacy of a New Low-Dose Oral Contraceptive With Drospirenone in Premenstrual Dysphoric Disorder
Abstract
OBJECTIVE: To compare the efficacy of a new low-dose oral contraceptive pill (OCP) formulation with placebo in reducing symptoms of premenstrual dysphoric disorder. METHODS: This multicenter, double-blind, randomized clinical trial consisted of 2 run-in and 3 treatment cycles with daily symptom charting; 450 women with symptoms of premenstrual dysphoric disorder were randomized to either placebo or an OCP formulation containing drospirenone 3 mg and ethinyl estradiol 20 microg. Hormones were administered for 24 days, followed by 4 days of inactive pills (24/4). RESULTS: Scores on the total Daily Record of Severity of Problems decreased by -37.49 in the drospirenone/ethinyl estradiol group and by -29.99 in the placebo group (adjusted mean difference -7.5, 95% confidence interval [CI] -11.2 to -3.8; P < .001 by rank analysis of covariance). Mood symptom scores were reduced by -19.2 and -15.3 in active-treatment and placebo groups, respectively (adjusted mean difference -3.9, 95% CI -5.84 to -2.01; P = .003); physical symptom scores were reduced by -10.7 and -8.6 in active-treatment and placebo groups, respectively (adjusted mean difference -2.1, 95% CI -3.3 to -0.95; P < .001); and behavioral symptom scores were reduced by -7.7 and -6.2 in active-treatment and placebo groups, respectively (adjusted mean difference -1.5, 95% CI -2.251 to -0.727; P < .001). Response, defined as a 50% decrease in daily symptom scores, occurred in 48% of the active-treatment group and 36% of the placebo group (relative risk 1.7, 95% CI 1.1 to 2.6; P = .015) and corresponds to a number-needed-to-treat of 8 patients. CONCLUSION: A 24/4 regimen of drospirenone 3 mg and ethinyl estradiol 20 mug improves symptoms associated with premenstrual dysphoric disorder. LEVEL OF EVIDENCE: I.
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Cites
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The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMS/PMDD)
Halbreich, U., Borenstein, J., Pearlstein, T., & Kahn, L. S. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00098-2 · Cited by 740
Self-citationPrevalence, incidence and stability of premenstrual dysphoric disorder in the community
WITTCHEN, H.-U., BECKER, E., LIEB, R., & KRAUSE, P. (2002) · Psychological Medicine · doi:10.1017/s0033291701004925 · Cited by 554
Fluoxetine in the Treatment of Premenstrual Dysphoria
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Hormone withdrawal symptoms in oral contraceptive users
Sulak, P. (2000) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(99)00524-4 · Cited by 274
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Cited by
O’Brien, P. M. S., Bäckström, T., Brown, C., Dennerstein, L., Endicott, J., Epperson, C. N., Eriksson, E., Freeman, E., Halbreich, U., Ismail, K. M. K., et al. (2011) · Archives of Women's Mental Health · doi:10.1007/s00737-010-0201-3 · Cited by 295
Self-citationDeecher, D., Andree, T. H., Sloan, D., & Schechter, L. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.006 · Cited by 270
Hormonal Treatments for Major Depressive Disorder: State of the Art
Dwyer, J. B., Aftab, A., Radhakrishnan, R., Widge, A., Rodriguez, C. I., Carpenter, L. L., Nemeroff, C. B., McDonald, W. M., Kalin, N. H., & APA Council of Research Task Force on Novel Biomarkers and Treatments (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19080848 · Cited by 252
ISPMD consensus on the management of premenstrual disorders
Consensus Group of the International Society for Premenstrual Disorders, Nevatte, T., O’Brien, P. M. S., Bäckström, T., Brown, C., Dennerstein, L., Endicott, J., Epperson, C. N., Eriksson, E., Freeman, E. W., et al. (2013) · Archives of Women s Mental Health · doi:10.1007/s00737-013-0346-y · Cited by 211
Hormonal Contraceptives and Mood: Review of the Literature and Implications for Future Research
Robakis, T., Williams, K. E., Nutkiewicz, L., & Rasgon, N. L. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1034-z · Cited by 103
Metadata
- Authors
- Yonkers, K. A., Brown, C., Pearlstein, T. B., Foegh, M., Sampson-Landers, C., & Rapkin, A.
- Venue
- Obstetrics & Gynecology
- Published
- 2005-09
- Volume
- 106
- Issue
- 3
- Pages
- 492-501
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W1998495772
- Cited by
- 349
- References
- 29
- FWCI
- 23.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Efficacy of a New Low-Dose Oral Contraceptive With Drospirenone in Premenstrual Dysphoric Disorder. https://app.cochat.ai/papers/10.1097/01.aog.0000175834.77215.2e
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- Yonkers, K. A., Brown, C., Pearlstein, T. B., Foegh, M., Sampson-Landers, C., & Rapkin, A. (2005). Efficacy of a New Low-Dose Oral Contraceptive With Drospirenone in Premenstrual Dysphoric Disorder. Obstetrics & Gynecology. https://doi.org/10.1097/01.aog.0000175834.77215.2e
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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