From menarche to menopause: Exploring the underlying biology of depression in women experiencing hormonal changes
Abstract
Epidemiologic data consistently report an elevated prevalence of major depressive disorder (MDD) in women. This increase begins during adolescence and continues through the menopausal transition. Population-based clinical studies report an increase in the incidence of MDD during perimenopause compared to either the premenopausal or postmenopausal period. Evidence suggests that fluctuations and decline of hormonal levels are correlated with this observed increase in risk for MDD. A strong predictor of depression in the perimenopausal period is a previous history of MDD. However, recent studies revealed an increased risk of new onset depression in perimenopausal women without a history of MDD. Additionally, recent reports have indicated that the presence of vasomotor symptoms may be associated with an increased the risk for MDD. The objective of this paper is to review evidence that would support our hypothesis that neurotransmitter systems are affected by changes in hormonal status over the course of a woman's life, leading to increase vulnerability to perimenopausal depression. Relevant data from nonclinical experiments will be discussed in the context of observed clinical evidence of the risk for MDD before, during, and after the menopausal transition. A testable hypothesis will be proposed to advance our understanding of hormonal effects on mood.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compared to the general population, women with ADHD are at increased risk of depression and depressive symptoms during periods of ovarian hormone fluctuations.
“Compared to the general population, women with ADHD are at increased risk of depression and depressive symptoms during periods of ovarian hormone fluctuations [20,41,89,90].”
From A Female-Specific Treatment Group for ADHD—Description of the Programme and Qualitative Analysis of First Experiences (2024) · cites this paper as [89]
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
Cross-national epidemiology of major depression and bipolar disorder
Weissman, M. M. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540040037030 · Cited by 2,302 · see citing works
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221 · see citing works
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · see citing works
Epidemiology of women and depression
Kessler, R. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00426-3 · Cited by 2,006 · see citing works
Estrogen Actions in the Central Nervous System
McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,483 · see citing works
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,438 · see citing works
Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
Gould, E., Woolley, C., Frankfurt, M., & McEwen, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01286.1990 · Cited by 1,406 · see citing works
Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,115 · see citing works
Woolley, C. S., & McEwen, B. S. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903360210 · Cited by 1,073 · see citing works
Forced swimming test in mice: A review of antidepressant activity
Petit-Demouliere, B., Chenu, F., & Bourin, M. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2048-7 · Cited by 1,003 · see citing works
Effects of gonadal steroids in women with a history of postpartum depression
Bloch, M., Schmidt, P. J., Danaceau, M., Murphy, J., Nieman, L., & Rubinow, D. R. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.924 · Cited by 950 · see citing works
Estrogen Actions Throughout the Brain
McEwen, B. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.357 · Cited by 915 · see citing works
Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.375 · Cited by 904 · see citing works
Differences between males and females in rates of serotonin synthesis in human brain
Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., & Dikšić, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5308 · Cited by 901 · see citing works
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841 · see citing works
Risk for New Onset of Depression During the Menopausal Transition
Cohen, L. S., Soares, C. N., Vitonis, A. F., Otto, M. W., & Harlow, B. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.385 · Cited by 836 · see citing works
Strategies and Methods for Research on Sex Differences in Brain and Behavior
Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S. A., Sadée, W., Steiner, M. S., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1142 · Cited by 799 · see citing works
Soares, C. N., Almeida, O., Joffe, H., & Cohen, L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.529 · Cited by 715 · see citing works
Woolley, C., Weiland, N., McEwen, B., & Schwartzkroin, P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01848.1997 · Cited by 711 · see citing works
Pet imaging of serotonin 1A receptor binding in depression
Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J., Huang, Y., Gautier, C., & Mathis, C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00189-4 · Cited by 666 · see citing works
Hormones and Menopausal Status as Predictors of Depression in Womenin Transition to Menopause
Freeman, E. W., Sammel, M. D., Liu, L., Gracia, C. R., Nelson, D. B., & Hollander, L. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.62 · Cited by 647 · see citing works
Estrogen Actions in the Central Nervous System
McEwen, B. S. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.279 · Cited by 640 · see citing works
Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.729 · Cited by 613 · see citing works
Estrogen replacement in perimenopause-related depression: A preliminary report
Schmidt, P. J., Nieman, L. K., Danaceau, M. A., Tobin, M., Roca, C. A., Murphy, J. H., & Rubinow, D. R. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106004 · Cited by 572 · see citing works
Sohrabji, F., Miranda, R. C., & Toran‐Allerand, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11110 · Cited by 560 · see citing works
Sex differences in rates of depression: cross-national perspectives
Weissman, M. M. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90025-f · Cited by 553 · see citing works
Characterization of reproductive hormonal dynamics in the perimenopause
Santoro, N. F., Brown, J., Adel, T., & Skurnick, J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636357 · Cited by 550 · see citing works
Animal models of anxiety and depression: how are females different?
Palanza, P. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00010-0 · Cited by 545 · see citing works
Oestrogen Therapy and the Menopausal Syndrome
Campbell, S. C., & Whitehead, M. I. (1977) · Clinics in Obstetrics and Gynaecology · doi:10.1016/s0306-3356(21)00374-5 · Cited by 542 · see citing works
Estrogen–serotonin interactions: implications for affective regulation
Rubinow, D. R., Schmidt, P. J., & Roca, C. A. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00162-0 · Cited by 501 · see citing works
Avis, N. E., Brambilla, D. J., McKinlay, S. M., & Vass, K. (1994) · Annals of Epidemiology · doi:10.1016/1047-2797(94)90099-x · Cited by 482 · see citing works
Walf, A. A., & Frye, C. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301067 · Cited by 461 · see citing works
Gender differences in depression: Findings from the STAR*D study
Marcus, S. M., Young, E. A., Kerber, K. B., Kornstein, S., Farabaugh, A. H., Mitchell, J., Wisniewski, S. R., Balasubramani, G. K., Trivedi, M. H., & Rush, A. J. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.09.008 · Cited by 456 · see citing works
O'Hara, M. W., Schlechte, J., Lewis, D. A., & Varner, M. W. (1991) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.100.1.63 · Cited by 453 · see citing works
Cross-national epidemiology of major depression and bipolar disorder
Weissman, M. M. (1996) · JAMA · doi:10.1001/jama.276.4.293 · Cited by 452 · see citing works
Estrogen, Menopause, and the Aging Brain: How Basic Neuroscience Can Inform Hormone Therapy in Women
Morrison, J. H., Brinton, R. D., Schmidt, P. J., & Gore, A. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3369-06.2006 · Cited by 388 · see citing works
Estrogen Therapy for Severe Persistent Depressions in Women
Klaiber, E. L. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780050060006 · Cited by 352 · see citing works
Efficacy of a New Low-Dose Oral Contraceptive With Drospirenone in Premenstrual Dysphoric Disorder
Yonkers, K. A., Brown, C., Pearlstein, T. B., Foegh, M. L., Sampson-Landers, C., & Rapkin, A. J. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000175834.77215.2e · Cited by 349 · see citing works
O’Hara, M. W., Schlechte, J., Lewis, D. A., et al. (1991) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.100.1.63 · Cited by 337 · see citing works
Cryan, J. F., Page, M. E., & Lucki, I. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0093-5 · Cited by 321 · see citing works
Parsey, R. V., Oquendo, M., Simpson, N. R., Ogden, R., Heertum, R. V. V., Arango, V., & Mann, J. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03243-2 · Cited by 318 · see citing works
Kunugi, H., Hattori, M., Kato, T., Tatsumi, M., Sakai, T., Sasaki, T., Hirose, T., & Nanko, S. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000334 · Cited by 305 · see citing works
Estrogen Deficiency in Severe Postpartum Depression
Ahokas, A., Kaukoranta, J., Wahlbeck, K., & Aito, M. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0504 · Cited by 261 · see citing works
Kugaya, A., Epperson, C. N., Zoghbi, S. S., van Dyck, C. H., Hou, Y., Fujita, M., Staley, J. K., Garg, P., Seibyl, J. P., & Innis, R. B. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1522 · Cited by 256 · see citing works
Cryan, J. F., O’Leary, O. F., Jin, S., Friedland, J. C., Ouyang, M., Hirsch, B. R., Page, M. E., Dalvi, A., THOMAS, S. A., & Lucki, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401080101 · Cited by 252 · see citing works
Schmidt, P. J., Haq, N., & Rubinow, D. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2238 · Cited by 251 · see citing works
Lack of efficacy of estradiol for depression in postmenopausal women: a randomized, controlled trial
Morrison, M. F., Kallan, M. J., Have, T. T., Katz, I. R., Tweedy, K., & Battistini, M. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.011 · Cited by 245 · see citing works
Ellenbogen, M. A. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00056-5 · Cited by 242 · see citing works
Harlow, B. L., Wise, L. A., Otto, M. W., Soares, C. N., & Cohen, L. S. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.29 · Cited by 236 · see citing works
Estrogen regulates functional inhibition of hippocampal CA1 pyramidal cells in the adult female rat
Rudick, C. N., & Woolley, C. S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06532.2001 · Cited by 228 · see citing works
Bebbington, P., Dunn, G., Jenkins, R., Lewis, G., Brugha, T. S., Farrell, M., & Meltzer, H. (2003) · International Review of Psychiatry · doi:10.1080/0954026021000045976 · Cited by 216 · see citing works
Antidepressant-Like Effect of Different Estrogenic Compounds in the Forced Swimming Test
Estrada-Camarena, E., Fernández-Guasti, A., & López-Rubalcava, C. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300097 · Cited by 211 · see citing works
Animal models of depression in drug discovery: A historical perspective
McArthur, R. A., & Borsini, F. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.06.005 · Cited by 209 · see citing works
Longitudinal study of hormone levels and depression among women transitioning through menopause
Avis, N. E., Crawford, S. L., Stellato, R. K., & Longcope, C. (2001) · Climacteric · doi:10.1080/cmt.4.3.243.249 · Cited by 209 · see citing works
Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques
Pecins-Thompson, M., Brown, N. A., & Bethea, C. L. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00286-6 · Cited by 203 · see citing works
SUMNER, B. E. H., & Fink, G. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00075-b · Cited by 202 · see citing works
Relative antidepressant efficacy of venlafaxine and SSRIs: sex-age interactions
Thase, M. E., Entsuah, R., Cantillon, M., & Kornstein, S. G. (2005) · Journal of Women s Health · doi:10.1089/jwh.2005.14.609 · Cited by 201 · see citing works
Symptom Experience After Discontinuing Use of Estrogen Plus Progestin
Ockene, J. K. (2005) · JAMA · doi:10.1001/jama.294.2.183 · Cited by 200 · see citing works
Gundlah, C., Kohama, S. G., Mirkes, S. J., Garyfallou, V. T., Urbanski, H. F., & Bethea, C. L. (2000) · Molecular Brain Research · doi:10.1016/s0006-8993(99)02475-0 · Cited by 199 · see citing works
Tang, Y. C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg121 · Cited by 197 · see citing works
Ovarian Steroid Regulation of Tryptophan Hydroxylase mRNA Expression in Rhesus Macaques
Pecins-Thompson, M., Brown, N. A., Kohama, S. G., & Bethea, C. L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-07021.1996 · Cited by 195 · see citing works
Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care
Joffe, H., Hall, J. E., Soares, C. N., Hennen, J. A., Reilly, C. J., Carlson, K., & Cohen, L. S. (2002) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200211000-00003 · Cited by 194 · see citing works
McQueen, J. K., Wilson, H., & Fink, G. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00233-1 · Cited by 189 · see citing works
Predictors of Mood Response to Acute Tryptophan Depletion A Reanalysis
Booij, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00361-5 · Cited by 186 · see citing works
Smith, L. J., Henderson, J. A., Abell, C. W., & Bethea, C. L. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300510 · Cited by 178 · see citing works
Moses, E. L., Drevets, W. C., Smith, G. S., Mathis, C. A., Kalro, B. N., Butters, M. A., Leondires, M. P., Greer, P. J., Lopresti, B. J., Loucks, T. L., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00967-7 · Cited by 175 · see citing works
Gundlah, C., Lu, N. Z., & Bethea, C. L. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0959-0 · Cited by 174 · see citing works
Walf, A., & Frye, C. (2007) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.003 · Cited by 166 · see citing works
Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques
Bethea, C. L., Mirkes, S. J., Shively, C. A., & Adams, M. R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00156-0 · Cited by 163 · see citing works
SUMNER, B. E. H., Grant, K. E., Rosie, R., Hegele-Hartung, C., Fritzemeier, K.-H., & Fink, G. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00243-0 · Cited by 154 · see citing works
Affective Symptoms in Women Attending a Menopause Clinic
Hay, A. G., Bancroft, J., & Johnstone, E. C. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.4.513 · Cited by 150 · see citing works
Pecins-Thompson, M., & Bethea, C. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00326-1 · Cited by 148 · see citing works
Riad, M., Watkins, K. C., Doucet, E., Hamon, M., & Descarries, L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08378.2001 · Cited by 142 · see citing works
Ovarian Steroid Regulation of 5-HT1A Receptor Binding and G protein Activation in Female Monkeys
Lu, N. Z. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00423-7 · Cited by 142 · see citing works
Gonadal steroid regulation of mood: The lessons of premenstrual syndrome☆
Rubinow, D. R., & SCHMIDT, P. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.02.003 · Cited by 134 · see citing works
Neuroendocrine Responses to Intravenous Tryptophan in Major Depression
Cowen, P. J. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800230038008 · Cited by 129 · see citing works
Chronobiological Basis of Female-Specific Mood Disorders
Parry, B. L. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00340-2 · Cited by 127 · see citing works
What should animal models of depression model?
Frazer, A., & Morilak, D. A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.006 · Cited by 126 · see citing works
Robichaud, M., & Debonnel, G. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01292.x · Cited by 125 · see citing works
Bancroft, J., Cook, A., Davidson, D., Bennie, J., & Goodwin, G. M. (1991) · Psychological Medicine · doi:10.1017/s0033291700020407 · Cited by 122 · see citing works
m, K. R. D., Bengtsson, C., Lissner, L., Milsom, I., Sundh, V., & Bj�rkelund, C. (2002) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200205000-00003 · Cited by 122 · see citing works
Bernardi, M. M., Vergoni, A. V., Sandrini, M., Tagliavini, S., & Bertolini, A. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90238-2 · Cited by 119 · see citing works
Jovanovic, H., Cerin, Å., Karlsson, P., Lundberg, J., Halldin, C., & Nordström, A. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.05.002 · Cited by 117 · see citing works
Jones, M. D., & Lucki, I. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300664 · Cited by 115 · see citing works
Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, −1438G/A
Enoch, M.-A., Goldman, D. A., Barnett, R. L., Sher, L., Mazzanti, C. M., & Rosenthal, N. E. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000439 · Cited by 115 · see citing works
Lu, N. Z., Eshleman, A. J., Janowsky, A. J., & Bethea, C. L. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001243 · Cited by 113 · see citing works
Etgen, A. M., Ansonoff, M. A., & Quesada, A. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1676 · Cited by 109 · see citing works
The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects
Charney, D. S., Heninger, G. R., Reinhard, J. F., Sternberg, D. E., & Hafstead, K. M. (1982) · Psychopharmacology · doi:10.1007/bf00464569 · Cited by 102 · see citing works
Premenstrual depression predicts future major depressive disorder
Graze, K., Nee, J., & Endicott, J. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb06479.x · Cited by 102 · see citing works
Gonadal hormones modulate 5-hydroxytryptamine2A receptors: emphasis on the rat frontal cortex
Cyr, M., Bossé, R., & Paolo, T. D. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00445-4 · Cited by 102 · see citing works
Interaction between estrogens and antidepressants in the forced swimming test in rats
Estrada-Camarena, E. M., Fernández‐Guasti, A., & López‐Rubalcava, C. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1707-4 · Cited by 102 · see citing works
Okada, M., Hayashi, N., Kometani, M., Nakao, K., & Inukai, T. (1997) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.73.93 · Cited by 100 · see citing works
Pinto‐Meza, A., Usall, J., Serrano‐Blanco, A., Suarez, D. L., & Haro, J. M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.02.010 · Cited by 97 · see citing works
Szabo, S. T., & Blier, P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033282 · Cited by 97 · see citing works
Moses‐Kolko, E. L., Berga, S. L., Greer, P. J., Smith, G. S., MELTZER, C. C., & Drevets, W. C. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00973-7 · Cited by 96 · see citing works
Pau, K.-Y. F., Hess, D. L., Kohama, S., Bao, J., Pau, C. Y., & Spies, H. G. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00549.x · Cited by 95 · see citing works
Redei, E., & Freeman, E. W. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00057-h · Cited by 92 · see citing works
Bekku, N., & Yoshimura, H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0179-0 · Cited by 89 · see citing works
Gundlah, C., Simon, L. D., & Auerbach, S. B. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01391-7 · Cited by 89 · see citing works
Relationship between psychological complaints and vasomotor symptoms during climacteric
Blümel, J. E., Castelo‐Branco, C., Hidalgo, M. J. C., Andrea Córdova, T., Binfa, L., Bonilla, H., Muñoz, I., Vergara, V. G., & Sarrá, S. (2004) · Maturitas · doi:10.1016/j.maturitas.2004.01.011 · Cited by 87 · see citing works
Blier, P. (2001) · PubMed Central · Cited by 86 · see citing works
Desensitization of 5-HT1A Receptors by 5-HT2A Receptors in Neuroendocrine Neurons in Vivo
Zhang, Y., Gray, T. S., D’Souza, D. N., Carrasco, G. A., Damjanoska, K. J., Dudás, B., García, F., Zainelli, G. M., Sullivan, N. R., Battaglia, G., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.062224 · Cited by 85 · see citing works
Biegon, A. R., Essar, N., Israeli, M., Elizur, A., Bruch, S., & Bar-Nathan, A. A. (1990) · Psychopharmacology · doi:10.1007/bf02245747 · Cited by 83 · see citing works
Harlow, B. L., Cohen, L. S., Otto, M. W., Spiegelman, D. L., & Cramer, D. W. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00459-7 · Cited by 80 · see citing works
Desipramine Treatment in Normal Subjects
Cowen, P. J. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800010063008 · Cited by 80 · see citing works
(2006) · PubMed · Cited by 77 · see citing works
Estradiol Regulation of α1b‐Adrenoceptor mRNA in Female Rat Hypothalamus‐Preoptic Area
Karkanias, G. B., Ansonoff, M. A., & Etgen, A. M. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04716.x · Cited by 74 · see citing works
Ovarian Steroid Action in the Serotonin Neural System of Macaques
Bethea, C. L., Gundlah, C., & Mirkes, S. J. (2000) · Novartis Foundation symposium · doi:10.1002/0470870818.ch9 · Cited by 73 · see citing works
Klink, R., Robichaud, M., & Debonnel, G. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00219-8 · Cited by 72 · see citing works
Endocrinology of Menopausal Transition and Its Brain Implications
Genazzani, A. R., Bernardi, F., Pluchino, N., Begliuomini, S., Lenzi, E., Casarosa, E., & Luisi, M. (2005) · CNS Spectrums · doi:10.1017/s1092852900023142 · Cited by 70 · see citing works
The GH response to clonidine in endogenous as compared with reactive depression
Checkley, S. A., Glass, I. B., Thompson, C. M., Corn, T. H., & Robinson, P. H. (1984) · Psychological Medicine · doi:10.1017/s0033291700019747 · Cited by 67 · see citing works
Tinkler, G. P., Tobin, J. R., & Voytko, M. L. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.11028 · Cited by 67 · see citing works
Lohff, J. C., Christian, P. J., Marion, S. L., & Hoyer, P. B. (2006) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000191883.59799.2e · Cited by 64 · see citing works
Estradiol attenuates alpha 2-adrenoceptor-mediated inhibition of hypothalamic norepinephrine release
Karkanias, G. B., & Etgen, A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03448.1993 · Cited by 56 · see citing works
Mood, neuropsychological function and cognitions in premenstrual dysphoric disorder
Man, M., MacMillan, I. C., Scott, J. L., & Young, A. H. (1999) · Psychological Medicine · doi:10.1017/s0033291798007715 · Cited by 56 · see citing works
Michel, M. C., Rother, A., Hiemke, C., & Ghraf, R. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90629-0 · Cited by 54 · see citing works
Karkanias, G. B., Li, C.-S., & Etgen, A. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00359-x · Cited by 51 · see citing works
Pindolol decreases prolactin and growth hormone responses to intravenousL-tryptophan
Smith, C. E., Ware, C., & Cowen, P. J. (1991) · Psychopharmacology · doi:10.1007/bf02244090 · Cited by 51 · see citing works
Factors producing a menopausal depressive-like state in mice following ovariectomy
Bekku, N., Yoshimura, H., & Araki, H. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0395-2 · Cited by 50 · see citing works
Sex Differences in Depressive Response During Monoamine Depletions in Remitted Depressive Subjects
Moreno, F., McGahuey, C. A., Freeman, M. P., & Delgado, P. L. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1019 · Cited by 49 · see citing works
Robichaud, M., & Debonnel, G. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1820011 · Cited by 49 · see citing works
Zhang, Y., D’Souza, D. N., Raap, D. K., García, F., Battaglia, G., Muma, N. A., & de Kar, L. D. V. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07919.2001 · Cited by 45 · see citing works
Carrasco, G. A., Barker, S. A., Zhang, Y., Damjanoska, K. J., Sullivan, N. R., García, F., D’Souza, D. N., Muma, N. A., & de Kar, L. D. V. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.031 · Cited by 45 · see citing works
O’Leary, O. F., Bechtholt, A. J., Crowley, J. J., Valentino, R. J., & Lucki, I. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.06.012 · Cited by 45 · see citing works
Mize, A. L., Young, L. J., & Alper, R. H. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00044-3 · Cited by 44 · see citing works
Saux, M. L., & Paolo, T. D. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0517 · Cited by 43 · see citing works
Nongenomic steroidal modulation of high-affinity serotonin transport
Chang, A. S., & Chang, S. M. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00255-7 · Cited by 39 · see citing works
SUMNER, B. E. H., Grant, K. E., Rosie, R., Hegele-Hartung, C., Fritzemeier, K., & Fink, G. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.039 · Cited by 39 · see citing works
Klink, R., Robichaud, M., & Debonnel, G. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00218-6 · Cited by 39 · see citing works
Woods, N. F., Mariella, A., & Mitchell, E. S. (2006) · Climacteric · doi:10.1080/13697130600730663 · Cited by 36 · see citing works
Landén, M., Thase, M. E., PhD, Thase, A. M. E., & Rush, A. J. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4160 · Cited by 35 · see citing works
Ghraf, R., Michel, M. C., Hiemke, C., & Knüppen, R. (1983) · Brain Research · doi:10.1016/0006-8993(83)90920-4 · Cited by 35 · see citing works
MohanKumar, P. S., ThyagaRajan, S., & QUADRI, S. K. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02031-4 · Cited by 33 · see citing works
Panek, D. U., & Dixon, W. R. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38947-0 · Cited by 30 · see citing works
Raap, D. K., DonCarlos, L. L., García, F., Zhang, Y., Muma, N. A., Battaglia, G., & de Kar, L. D. V. (2002) · Neuroendocrinology · doi:10.1159/000067582 · Cited by 26 · see citing works
Mood Changes following Acute Tryptophan Depletion in Healthy Adults
Schmeck, K., Sadigorsky, S., Englert, E., Demisch, L., Dierks, T., Barta, S. K., & Poustka, F. (2002) · Psychopathology · doi:10.1159/000063827 · Cited by 20 · see citing works
Symptoms of depression in late luteal phase dysphoric disorder: A variant of mood disorder?
Ronchi, D. D., Ujkaj, M., Boaron, F., Muro, A., Piselli, M., & Quartesan, R. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.01.013 · Cited by 20 · see citing works
Replacement Estrogen Therapy for Menopausal Vasomotor Flushes
Baumgardner, S., CONDREA, H., Daane, T. A., DORSEY, H. J., Jurow, H. N., SHIVELY, P. J., WACHSMAN, M., Wharton, L. R., & ZIBEL, M. J. (1978) · Obstetrics and Gynecology · doi:10.1097/00006250-197804000-00013 · Cited by 18 · see citing works
Epperson, C. N., Amin, Z., Naftolin, F. N., Cappiello, A., Czarkowski, K. A., Stiklus, S. M., Anderson, G. M., & Krystal, J. H. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106067330 · Cited by 14 · see citing works
Effect of amitriptyline on endocrine responses to intravenous L-trytophan
Cowen, P. J., McCance, S., Gelder, M., & Grahame‐Smith, D. G. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90122-l · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Perimenopause as a neurological transition state
Brinton, R. D., Yao, J., Yin, F., Mack, W. J., & Cadenas, E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.82 · Cited by 612 · see citing works
Pereira-Miranda, E., Costa, P. R. F., Queiroz, V. A. O., Pereira-Santos, M., & Santana, M. L. P. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1261053 · Cited by 335 · see citing works
Meta-review of depressive subtyping models
Harald, B., & Gordon, P. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.015 · Cited by 328 · see citing works
Kundaković, M., & Rocks, D. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101010 · Cited by 333 · see citing works
Gordon, J. L., Girdler, S. S., Meltzer-Brody, S. E., Stika, C. S., Thurston, R. C., Clark, C. T., Prairie, B. A., Moses‐Kolko, E. L., Joffe, H., & Wisner, K. L. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070918 · Cited by 288 · see citing works
Risk of Obsessive-Compulsive Disorder in Pregnant and Postpartum Women: A Meta-Analysis
Russell, E. J., Fawcett, J. M., & Mazmanian, D. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07917 · Cited by 229 · see citing works
Variation in symptoms of depression and anxiety in midlife women by menopausal status
Mulhall, S., Andel, R., & Anstey, K. J. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.11.005 · Cited by 174 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
Sex-Specific Physiology and Cardiovascular Disease
SHUFELT, C. L., Pacheco, C., Tweet, M. S., & Miller, V. M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_27 · Cited by 172 · see citing works
Menopause and depression: is there a link?
Vivian-Taylor, J., & Hickey, M. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.05.014 · Cited by 162 · see citing works
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
Dudek, K., Dion‐Albert, L., Kaufmann, F. N., Tuck, E., Lebel, M., & Ménard, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14547 · Cited by 156 · see citing works
Lokuge, S., Frey, B. N., Foster, J. A., Soares, C. N., & Steiner, M. S. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11com07089 · Cited by 148 · see citing works
A Reproductive Subtype of Depression
Payne, J. L., Palmer, J. T., & Joffe, H. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902899706 · Cited by 144 · see citing works
Hernández-Hernández, O. T., Martı́nez-Mota, L., Herrera‐Perez, J. J., & Jiménez-Rubio, G. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180628165107 · Cited by 139 · see citing works
Characterizing the trajectories of vasomotor symptoms across the menopausal transition
Tepper, P. G., Brooks, M. M., Randolph, J. F., Crawford, S. L., Khoudary, S. R. E., Gold, E. B., Lasley, B. L., Jones, B. L., Joffe, H., Hess, R., et al. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000676 · Cited by 138 · see citing works
Kiss, Á., Delattre, A. M., Pereira, S. I. R., Carolino, R. O. G., Szawka, R. E., Anselmo-Franci, J. A., Zanata, S. M., & Ferraz, A. C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.047 · Cited by 137 · see citing works
Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice
LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J. W., Kalahasti, G., Bradbury, K. R., Taylor, S. V., Maze, I., Kumar, A., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.024 · Cited by 136 · see citing works
Sex Differences in Response to Stress and Expression of Depressive-Like Behaviours in the Rat
Dalla, C., Pitychoutis, P. M., Kokras, N., & Papadopoulou‐Daifoti, Z. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_94 · Cited by 134 · see citing works
Mood disorders in midlife women
Soares, C. N. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000193 · Cited by 136 · see citing works
Mehta, D., Newport, D. J., Frishman, G., Kraus, L., Rex‐Haffner, M., Ritchie, J., Lori, A., Knight, B. T., Stagnaro, E., Ruepp, A., et al. (2014) · Psychological Medicine · doi:10.1017/s0033291713003231 · Cited by 132 · see citing works
Helle, N., Barkmann, C., Bartz-Seel, J., Diehl, T., Ehrhardt, S., Hendel, A., Nestoriuc, Y., Schulte-Markwort, M., von der Wense, A., & Bindt, C. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.001 · Cited by 115 · see citing works
Schweizer-Schubert, S., Gordon, J. L., Eisenlohr-Moul, T. A., Meltzer-Brody, S. E., Schmalenberger, K. M., Słopień, R., Zietlow, A., Ehlert, U., & Ditzen, B. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.479646 · Cited by 118 · see citing works
Why the estrous cycle matters for neuroscience
Rocks, D., Cham, H., & Kundaković, M. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00466-8 · Cited by 110 · see citing works
Menstrual cycle-related exacerbation of disease
Pinkerton, J. V., Guico‐Pabia, C. J., & Taylor, H. S. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.061 · Cited by 108 · see citing works
Inflaming sex differences in mood disorders
Rainville, J. R., & Hodes, G. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0124-7 · Cited by 106 · see citing works
Effects of the menstrual cycle on bipolar disorder
Teatero, M. L., Mazmanian, D., & Sharma, V. (2014) · Bipolar Disorders · doi:10.1111/bdi.12138 · Cited by 99 · see citing works
Frey, B. N., Lord, C., & Soares, C. N. (2008) · Menopause international · doi:10.1258/mi.2008.008019 · Cited by 102 · see citing works
Bindt, C., Appiah‐Poku, J., Bonle, M. T., Schoppen, S., Feldt, T., Barkmann, C., Koffi, M., Baum, J., Nguah, S. B., Tagbor, H. K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048396 · Cited by 101 · see citing works
Epidemiology of antenatal depression in Africa: a systematic review and meta-analysis
Dadi, A. F., Wolde, H. F., Baraki, A. G., & Akalu, T. Y. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-02929-5 · Cited by 95 · see citing works
Premenstrual Exacerbations of Mood Disorders: Findings and Knowledge Gaps
Kuehner, C., & Nayman, S. (2021) · Current Psychiatry Reports · doi:10.1007/s11920-021-01286-0 · Cited by 93 · see citing works
Melatonin in perimenopausal and postmenopausal women
Toffol, E., Kalleinen, N., Haukka, J. K., Vakkuri, O., Partonen, T., & Polo‐Kantola, P. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182a6c8f3 · Cited by 92 · see citing works
Soares, C. N. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0100-1 · Cited by 94 · see citing works
Stress and coping in women with breast cancer:unravelling the mechanisms to improve resilience
Borgi, M., Collacchi, B., Ortona, E., & Cirulli, F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.011 · Cited by 90 · see citing works
Hormone therapy and mood in perimenopausal and postmenopausal women
Toffol, E., Heikinheimo, O., & Partonen, T. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000323 · Cited by 89 · see citing works
Jarić, I., Rocks, D., Cham, H., Herchek, A., & Kundaković, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00074 · Cited by 86 · see citing works
Sex differences in the blood–brain barrier: Implications for mental health
Dion‐Albert, L., Binder, L. B., Daigle, B., Hong-Minh, A., Lebel, M., & Ménard, C. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100989 · Cited by 89 · see citing works
Depression and midlife: Are we overpathologising the menopause?
Judd, F. K., Hickey, M., & Bryant, C. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.12.010 · Cited by 87 · see citing works
Pubertal timing, menstrual irregularity, and mental health: results of a population-based study
Toffol, E., Koponen, P., Luoto, R. M., & Partonen, T. (2013) · Archives of Women s Mental Health · doi:10.1007/s00737-013-0399-y · Cited by 85 · see citing works
Association study of the estrogen receptor gene ESR1 with postpartum depression—a pilot study
Pinsonneault, J. K., Sullivan, D., Sadée, W., Soares, C. N., Hampson, E., & Steiner, M. S. (2013) · Archives of Women s Mental Health · doi:10.1007/s00737-013-0373-8 · Cited by 83 · see citing works
Soares, C. N. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.01.007 · Cited by 82 · see citing works
Soares, C. N. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.03.001 · Cited by 82 · see citing works
Chronic conditions in women: the development of a National Institutes of health framework
Temkin, S. M., Barr, E., Moore, H. M., Caviston, J. P., Regensteiner, J. G., & Clayton, J. A. (2023) · BMC Women s Health · doi:10.1186/s12905-023-02319-x · Cited by 82 · see citing works
Society and ‘good woman’: A critical review of gender difference in depression
Maji, S. (2018) · International Journal of Social Psychiatry · doi:10.1177/0020764018765023 · Cited by 77 · see citing works
Freeman, E. W. (2015) · Women s Midlife Health · doi:10.1186/s40695-015-0002-y · Cited by 74 · see citing works
Zsido, R. G., Williams, A. N., Barth, C., Serio, B., Kurth, L., Mildner, T., Trampel, R., Beyer, F., Witte, A. V., Villringer, A., et al. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00125-w · Cited by 76 · see citing works
Hickey, M., Elliott, J., & Davison, S. L. (2012) · BMJ · doi:10.1136/bmj.e763 · Cited by 74 · see citing works
Hajszán, T., Szigeti‐Buck, K., Sallam, N. L., Bober, J., Párducz, Á., MacLusky, N. J., Léránth, C., & Duman, R. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.017 · Cited by 73 · see citing works
Deciphering sex differences in the immune system and depression
Rainville, J. R., Tsyglakova, M., & Hodes, G. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.004 · Cited by 69 · see citing works
Neural correlates of depression in women across the reproductive lifespan – An fMRI review
Stickel, S., Wagels, L., Wudarczyk, O. A., Jaffee, S. R., Habel, U., Schneider, F. W., & Chechko, N. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.133 · Cited by 70 · see citing works
Sex, hormones and neuroeffector mechanisms
Hart, E. C., Charkoudian, N., & Miller, V. M. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02192.x · Cited by 68 · see citing works
DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons
Oh, G., Wang, S.-C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.016 · Cited by 66 · see citing works
McNamara, R. K., Able, J. A., Jandacek, R. J., Rider, T., & Tso, P. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.013 · Cited by 66 · see citing works
Fafouti, M., Paparrigopoulos, T. J., Zervas, Y., Rabavilas, A. D., Malamos, N. A., Liappas, I., & Tzavara, C. K. (2010) · PubMed · Cited by 66 · see citing works
Evaluation and management of depressive and anxiety symptoms in midlife
Hickey, M., Bryant, C., & Judd, F. K. (2011) · Climacteric · doi:10.3109/13697137.2011.620188 · Cited by 64 · see citing works
The Influence of genetic factors on peripartum depression: A systematic review
de Figueiredo, F. P., Parada, A. P., de Araújo, L. F., Silva, W. A., & Del‐Ben, C. M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.10.016 · Cited by 62 · see citing works
Reproductive Hormones and Female Mental Wellbeing
Wieczorek, K., Targonskaya, A., & Maslowski, K. (2023) · Women · doi:10.3390/women3030033 · Cited by 61 · see citing works
Hormone-related factors and post-menopausal onset depression: Results from KNHANES (2010–2012)
Jung, S. J., Shin, A., & Kang, D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.061 · Cited by 60 · see citing works
Understanding the Biological Relationship between Migraine and Depression
Viudez‐Martínez, A., Torregrosa, A. B., Navarrete, F., & García‐Gutiérrez, M. S. (2024) · Biomolecules · doi:10.3390/biom14020163 · Cited by 55 · see citing works
Verit, F. F., Verit, A., & Billurcu, N. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.07.002 · Cited by 52 · see citing works
Natari, R. B., Clavarino, A. M., McGuire, T., Dingle, K. D., & Hollingworth, S. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000949 · Cited by 52 · see citing works
Kinser, P. A., & Lyon, D. (2014) · Brain and Behavior · doi:10.1002/brb3.249 · Cited by 53 · see citing works
Hildreth, K. L., Ozemek, C., Kohrt, W., Blatchford, P., & Moreau, K. (2018) · Menopause · doi:10.1097/gme.0000000000001112 · Cited by 44 · see citing works
Factors Associated with Depression During the Perimenopausal Transition
Gibbs, Z., Lee, S. J., & Kulkarni, J. (2013) · Women s Health Issues · doi:10.1016/j.whi.2013.07.001 · Cited by 48 · see citing works
Behr, G. A., Schnorr, C. E., & Moreira, J. C. F. (2011) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00923.x · Cited by 46 · see citing works
Sárvári, M., Deli, L., Kocsis, P., Márk, L., Maász, G., Hrabovszky, E., Kalló, I., Gajári, D., Vastagh, C., Sümegi, B., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.020 · Cited by 47 · see citing works
Colvin, A. B., Richardson, G. A., Cyranowski, J. M., Youk, A. O., & Bromberger, J. T. (2017) · Depression and Anxiety · doi:10.1002/da.22651 · Cited by 47 · see citing works
Oral contraceptives positively affect mood in healthy PMS-free women: A longitudinal study
Hamstra, D. A., de Kloet, E. R., de Rover, M., & Van der Does, W. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.10.011 · Cited by 41 · see citing works
Demétrio, F. N., Rennó, J., Gianfaldoni, A., Gonçalves, M. A., Halbe, H. W., Filho, A. H. G. V., & Gorenstein, C. (2011) · Archives of Women s Mental Health · doi:10.1007/s00737-011-0241-3 · Cited by 45 · see citing works
Challenges and Opportunities to Manage Depression During the Menopausal Transition and Beyond
Soares, C. N., & Frey, B. N. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.01.007 · Cited by 46 · see citing works
Age at menarche and depression: results from the NHANES 2005–2016
Shen, Y., Varma, D. S., Zheng, Y., Boc, J., & Hu, H. Z. (2019) · PeerJ · doi:10.7717/peerj.7150 · Cited by 45 · see citing works
Reis, F., Pestana‐Oliveira, N., Leite, C. M., Lima, F. B., Brandão, M. L., Graeff, F. G., Del‐Ben, C. M., & Anselmo-Franci, J. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.019 · Cited by 46 · see citing works
Depression Associated With Hormonal Contraceptive Use as a Risk Indicator for Postpartum Depression
Larsen, S. V., Mikkelsen, A. P., Lidegaard, Ø., & Frøkjær, V. G. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.0807 · Cited by 41 · see citing works
Faron‐Górecka, A., Kuśmider, M., Solich, J., Kolasa, M., Szafran‐Pilch, K., Żurawek, D., Pabian, P., & Dziedzicka‐Wasylewska, M. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71525-1 · Cited by 40 · see citing works
Hormonal therapies for new onset and relapsed depression during perimenopause
Worsley, R., Davis, S. R., Gavrilidis, E., Gibbs, Z., Lee, S. J., Burger, H., & Kulkarni, J. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.06.011 · Cited by 40 · see citing works
Skovlund, C. W., Kessing, L. V., Mørch, L. S., & Lidegaard, Ø. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1305445 · Cited by 39 · see citing works
Zsido, R. G., Villringer, A., & Sacher, J. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1397607 · Cited by 39 · see citing works
Association between bullying at work and mental disorders: gender differences in the Italian people
Nolfe, G., Petrella, C., Zontini, G., Uttieri, S., & Nolfe, G. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-009-0155-9 · Cited by 39 · see citing works
Colangelo, L. A., Craft, L. L., Ouyang, P., Liu, K., Schreiner, P. J., Michos, E. D., & Gapstur, S. M. (2012) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182432de6 · Cited by 38 · see citing works
Role of estrogen in treatment of female depression
Sun, Q., Li, G., Zhao, F., Dong, M., Xie, W., Liu, Q., Yang, W., & Cui, R. (2024) · Aging · doi:10.18632/aging.205507 · Cited by 37 · see citing works
Du, X., Pang, T. Y., Mo, C., Renoir, T., Wright, D. J., & Hannan, A. J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.09.009 · Cited by 37 · see citing works
The hormonal sensitivity hypothesis: A review and new findings
Pope, C. J., Oinonen, K. A., Mazmanian, D. S., & Stone, S. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.03.012 · Cited by 36 · see citing works
Morrone, M. D. S., Schnorr, C. E., Behr, G. A., Gasparotto, J., Bortolin, R. C., Moresco, K. S., Bittencourt, L. D. S., Zanotto‐Filho, A., Gelain, D. P., & Moreira, J. C. F. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.03.010 · Cited by 36 · see citing works
Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens
Pfau, M. L., Purushothaman, I., Feng, J., Golden, S. A., Aleyasin, H., Lorsch, Z. S., Cates, H. M., Flanigan, M. E., Ménard, C., Heshmati, M., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00144 · Cited by 35 · see citing works
Edgcomb, J. B., Thiruvalluru, R. K., Pathak, J., & Brooks, J. O. (2021) · Medical Care · doi:10.1097/mlr.0000000000001467 · Cited by 35 · see citing works
Zhang, J., Yin, J., Song, X., Lai, S., Zhong, S., & Jia, Y. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.04.002 · Cited by 35 · see citing works
Lindberg, M., Foldemo, A., Josefsson, A., & Wiréhn, A.-B. (2012) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625187.2012.658925 · Cited by 34 · see citing works
BMI correlation with psychiatric problems among 10-18 years Iranian students.
Zakeri, M., Sedaghat, M., Motlagh, M. E., Ashtiani, R. T., & Ardalan, G. (2012) · PubMed · Cited by 33 · see citing works
Schlack, R., & Petermann, F. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-628 · Cited by 33 · see citing works
Khayum, M. A., Moraga‐Amaro, R., Buwalda, B., Koole, M. J. B., den Boer, J. A., Dierckx, R., Doorduin, J., & de Vries, E. F. J. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104610 · Cited by 32 · see citing works
Simmons, J. G., Nathan, P. J., Berger, G. E., & Allen, N. B. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2265-9 · Cited by 33 · see citing works
Pestana‐Oliveira, N., Kalil, B., Leite, C. M., Carolino, R. O. G., Debarba, L. K., Elias, L. L. K., Antunes‐Rodrigues, J., & Anselmo-Franci, J. A. (2018) · eNeuro · doi:10.1523/eneuro.0247-17.2017 · Cited by 30 · see citing works
Berg, N., Kiviruusu, O., Lintonen, T., & Huurre, T. (2019) · Scandinavian Journal of Public Health · doi:10.1177/1403494818769174 · Cited by 30 · see citing works
Hu, S. C., Chen, G., & Tu, H. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3145 · Cited by 30 · see citing works
Vitamin D and Depression in Women: A Mini-review
Boulkrane, M. S., Fedotova, J., Kolodyaznaya, V. S., Micale, V., Drago, F., van den Tol, A. J. M., & Baranenko, D. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191108111120 · Cited by 32 · see citing works
Kornstein, S. G., Clayton, A. H., Bao, W., & Guico‐Pabia, C. J. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.4900 · Cited by 30 · see citing works
Bütikofer, A., Cronin, C. J., & Skira, M. M. (2020) · Journal of Health Economics · doi:10.1016/j.jhealeco.2020.102348 · Cited by 29 · see citing works
Bloch, M., Azem, F., Aharonov, I., Avi, I. B., Yagil, Y., Schreiber, S., Amit, A., & Weizman, A. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.07.1073 · Cited by 29 · see citing works
Antidepressants and menstruation disorders in women: a cross-sectional study in three centers
Uğuz, F., Şahingöz, M., Köse, S. A., Ozbebit, O., Şengül, C., Selvı, Y., Şengül, C. B., Ayhan, M. G., Dagistanli, A., & Aşkın, R. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.03.014 · Cited by 27 · see citing works
The unique symptom profile of perimenopausal depression
Gibbs, Z., Lee, S. J., & Kulkarni, J. (2014) · Clinical Psychologist · doi:10.1111/cp.12035 · Cited by 27 · see citing works
- Authors
- Deecher, D., Andree, T. H., Sloan, D., & Schechter, L. E.
- Affiliations
- Wyeth (US)
- Corresponding author
- Deecher, Darlene
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 33
- Issue
- 1
- Pages
- 3-17
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2006693696
- Cited by
- 270
- References
- 142
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 14 · 2023: 18 · 2022: 15 · 2021: 10 · 2020: 10 · 2019: 12 · 2018: 22 · 2017: 19 · 2016: 11 · 2015: 15 · 2014: 20 · 2013: 18 · 2012: 14
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- perimenopausal depression, major depressive disorder, menopause, hormonal changes, sex differences in depression, neurotransmitter systems, vasomotor symptoms, menarche, postmenopausal depression, risk factors for depression, hypothalamic-pituitary-adrenal axis
- MeSH terms
- Adolescent, Adult, Aged, Animals, Major Depressive Disorder, Female, Humans, Menarche, Menopause, Menstrual Cycle, Middle Aged, Receptors, Adrenergic, Receptors, Serotonin, Gonadal Steroid Hormones, Women's Health
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
