The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Capillary Deposition of Complement Split Product C4d in Renal Allografts is Associated with Basement Membrane Injury in Peritubular and Glomerular Capillaries: A Contribution of Humoral Immunity to Chronic Allograft Rejection
Abstract
Endothelial deposition of the complement split product C4d is an established marker of antibody-mediated acute renal allograft rejection. A contribution of alloantibody-dependent immune reactions to chronic rejection is under discussion. In this study, the association of immunohistochemically detected endothelial C4d deposition in peritubular capillaries (PTC) with morphologic features of chronic renal allograft injury was investigated in a large study cohort. C4d deposits in PTC were detected in 73 (34%) of 213 late allograft biopsies performed in 213 patients more than 12 mo after transplantation (median, 4.9 yr) because of chronic allograft dysfunction. Endothelial C4d deposition was found to be associated with chronic transplant glomerulopathy (CG) (P < 0.0001), with basement membrane multilayering in PTC (P = 0.01), and with an accumulation of mononuclear inflammatory cells in PTC (P < 0,001). Furthermore, C4d deposits in PTC (in biopsies with normal glomerular morphology) were associated with development of CG in follow-up biopsies. Other morphologic features of chronic allograft nephropathy (with exception of tubular atrophy) were not associated with C4d deposits in PTC. Analyses of previous and follow-up biopsies revealed that C4d deposits may occur de novo and may also disappear at any time after transplantation. In conclusion, the data suggest that complement activation in renal microvasculature, indicating humoral alloreactivity, contributes to chronic rejection characterized by chronic transplant glomerulopathy and basement membrane multilayering in PTC.
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Cites
The Banff 97 working classification of renal allograft pathology
Racusen, L. C., Solez, K., Colvin, R. B., Bonsib, S. M., Castro, M. C., Cavallo, T., Croker, B. P., Demetris, A. J., Drachenberg, C. B., Fogo, A. B., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00299.x · Cited by 3,033
Capillary deposition of C4d complement fragment and early renal graft loss
Feucht, H. E., Schneeberger, H., Hillebrand, G., Burkhardt, K., Weiss, M., Riethmüller, G., Land, W., & Albert, E. (1993) · Kidney International · doi:10.1038/ki.1993.187 · Cited by 542
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Rethinking Chronic Allograft Nephropathy: The Concept of Accelerated Senescence
HALLORAN, P. F., MELK, A., & BARTH, C. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v101167 · Cited by 452
Chronic allograft nephropathy: An update
Paul, L. C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00611.x · Cited by 364
Crespo, M., Pascual, M., Tolkoff-Rubin, N., Mauiyyedi, S., Bernard Collins, A., Fitzpatrick, D., Lin Farrell, M., Williams, W. W., Delmonico, F. L., Benedict Cosimi, A., et al. (2001) · Transplantation · doi:10.1097/00007890-200103150-00013 · Cited by 351
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Self-citationNickeleit, V., Zeiler, M., Gudat, F., Thiel, G., & Mihatsch, M. J. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131242 · Cited by 311
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Specimen preparation for electron microscopy using low temperature embedding resins
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Cited by
Solez, K., Colvin, R., Racusen, L., Sis, B., Halloran, P., Birk, P., Campbell, P., Cascalho, M., Collins, A., Demetris, A., et al. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01688.x · Cited by 1,082
Effector Mechanisms of Rejection
Moreau, A., Varey, E., Anegon, I., & Cuturi, M.-C. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015461 · Cited by 189
High Risk of Sensitization After Failed Islet Transplantation
Campbell, P. M., Senior, P. A., Salam, A., LaBranche, K., Bigam, D. L., Kneteman, N. M., Imes, S., Halpin, A., Ryan, E. A., & Shapiro, A. M. J. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.01923.x · Cited by 173
Kim, Y.-G., Choi, G., Go, H., Cho, Y., Lee, H., Lee, A.-R., Park, B., & Kim, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-41479-5 · Cited by 29
Metadata
- Authors
- Regele, H., Böhmig, G. A., Habicht, A., Gollowitzer, D., Schillinger, M., Rockenschaub, S., Watschinger, B., Kerjaschki, D., & Exner, M.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2002-09
- Volume
- 13
- Issue
- 9
- Pages
- 2371-2380
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2144784671
- Cited by
- 423
- References
- 20
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Capillary Deposition of Complement Split Product C4d in Renal Allografts is Associated with Basement Membrane Injury in Peritubular and Glomerular Capillaries: A Contribution of Humoral Immunity to Chronic Allograft Rejection. https://app.cochat.ai/papers/10.1097/01.asn.0000025780.03790.0f
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- Regele, H., Böhmig, G. A., Habicht, A., Gollowitzer, D., Schillinger, M., Rockenschaub, S., Watschinger, B., Kerjaschki, D., & Exner, M. (2002). Capillary Deposition of Complement Split Product C4d in Renal Allografts is Associated with Basement Membrane Injury in Peritubular and Glomerular Capillaries: A Contribution of Humoral Immunity to Chronic Allograft Rejection. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000025780.03790.0f
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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