The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Arterial Calcifications and Bone Histomorphometry in End-Stage Renal Disease
Abstract
Arterial calcification (AC) is a common complication of end-stage renal disease (ESRD). The mechanisms responsible are complex, including disturbances of mineral metabolism and active expression of various mineral-regulating proteins. An inverse relationship between AC and bone density has been documented in uremic patients. In the study presented here, which included 58 patients with ESRD on hemodialysis (HD), bone-histomorphometry characteristics were compared with the AC scores (0 to 4) determined according to the number of arterial sites with calcifications. Patients with AC scores of 0 (no calcifications), or 1 or 2 (mild calcifications) had similar serum parathyroid hormone levels and bone histomorphometry, with larger osteoclast resorption, higher osteoclast numbers, and larger osteoblastic and double tertracycline-labeled surfaces. In contrast, patients with high AC scores (3 and 4) were characterized by lower serum parathyroid hormone, low osteoclast numbers and osteoblastic surfaces, smaller or absent double tetracycline-labeled surfaces, and high percentages of aluminum-stained surfaces. According to multivariate analysis, AC score was positively associated with age (P < 0.0001), daily dose of calcium-containing phosphate binders (P = 0.009), and bone aluminum-stained surfaces (P = 0.037), and an inverse correlation was observed with osteoblastic surfaces (P = 0.001). A high AC score is associated with bone histomorphometry suggestive of low bone activity and adynamic bone disease. These findings suggest that therapeutic interventions associated with excessive lowering of parathyroid activity (parathyroidectomy, excessive calcium or aluminum load) favor lower bone turnover and adynamic bone disease, which could influence the development and progression of AC.
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London, G. M. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg414 · Cited by 1,859
Self-citationSevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients
Chertow, G. M., Burke, S. K., Raggi, P., & for the Treat to Goal Working Group (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00434.x · Cited by 1,462
Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease
Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., & London, G. M. (2001) · Hypertension · doi:10.1161/hy1001.096358 · Cited by 1,417
Self-citationGANESH, S. K., STACK, A. G., LEVIN, N. W., HULBERT-SHEARON, T., & PORT, F. K. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12102131 · Cited by 1,204
Cardiac calcification in adult hemodialysis patients
Raggi, P., Boulay, A., Chasan-Taber, S., Amin, N., Dillon, M., Burke, S. K., & Chertow, G. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01781-8 · Cited by 1,116
Arterial stiffening and vascular calcifications in end‐stage renal disease
Guérin, A. P., London, G. M., Marchais, S. J., & Metivier, F. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.7.1014 · Cited by 1,003
Self-citationSchäfer, C., Heiss, A., Schwarz, A., Westenfeld, R., Ketteler, M., Floege, J., Müller-Esterl, W., Schinke, T., & Jahnen-Dechent, W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17202 · Cited by 924
The Effects of Parathyroid Hormone, Alendronate, or Both in Men with Osteoporosis
Finkelstein, J. S., Hayes, A., Hunzelman, J. L., Wyland, J. J., Lee, H., & Neer, R. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035725 · Cited by 829
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Guidelines for the management of chronic kidney disease
Levin, A., Hemmelgarn, B., Culleton, B., Tobe, S., McFarlane, P., Ruzicka, M., Burns, K., Manns, B., White, C., Madore, F., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.080351 · Cited by 420
Garcia-Bello, J. A., Gómez-Díaz, R. A., Contreras-Rodríguez, A., Talavera, J. O., Mondragón-González, R., Sanchez-Barbosa, L., Diaz-Flores, M., Valladares-Salgado, A., Gallardo, J. M., Aguilar-Kitsu, A., et al. (2014) · Pediatric Nephrology · doi:10.1007/s00467-013-2626-1 · Cited by 26
Yoon, C.-Y., Park, J., Seo, C., Nam, B. Y., Kim, S., Kee, Y. K., Lee, M., Cha, M.-U., Kim, H., Park, S., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2907 · Cited by 8
Metadata
- Authors
- London, G. M., Marty, C., Marchais, S. J., Guerin, A. P., Metivier, F., & de Vernejoul, M.-C.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2004-07
- Volume
- 15
- Issue
- 7
- Pages
- 1943-1951
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2105288874
- Cited by
- 594
- References
- 38
- FWCI
- 21.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- London, G. M., Marty, C., Marchais, S. J., Guerin, A. P., Metivier, F., & de Vernejoul, M.-C. (2004). Arterial Calcifications and Bone Histomorphometry in End-Stage Renal Disease. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000129337.50739.48
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