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Low Dentin Matrix Protein 1 Is Associated With Incident Cardiovascular Events in Peritoneal Dialysis Patients
Open accessAbstract
Recent reports demonstrated that dentin matrix protein 1 (DMP1) acts as an inhibitor of vascular calcification and might be a potential biomarker for chronic kidney disease-mineral and bone disorder; however, no clinical investigations regarding DMP1 have been performed in dialysis patients. We investigated the prognostic value of DMP1 on cardiovascular outcomes in prevalent peritoneal dialysis patients. We recruited 223 prevalent peritoneal dialysis patients and divided them into high and low DMP1 groups according to log-transformed plasma DMP1 levels. Lateral lumbar spine radiographs were used for measurement of vascular calcification. Major cardiovascular events were compared between the two groups. A Cox proportional hazards analysis determined DMP1 was independently associated with cardiovascular outcomes. In vitro mouse osteocytes were cultured in media containing indoxyl sulfate (IS), and the expressions of DMP1 were examined. The mean age was 52.1 ± 11.8 years, and 116 (52.0%) patients were male. The median value of log DMP1 was 0.91 (0.32–2.81 ng/mL). The multiple logistic regression analysis indicated that DMP1 levels were independently associated with the presence of vascular calcification after adjustment for multiple confounding factors (odds ratio = 0.719; 95% confidence interval [CI] 0.522–0.989; p = 0.043). During a mean follow-up duration of 34.6 months, incident cardiovascular events were observed in 41 (18.4%) patients. A Kaplan-Meier plot showed that the low DMP1 group had a significantly higher rate of incident cardiovascular events compared with the high DMP1 group (log-rank test, p = 0.026). In addition, multiple Cox analysis showed that low DMP1 was significantly associated with incident cardiovascular events (log 1 increase: hazard ratio = 0.855; 95% CI 0.743–0.984; p = 0.029) after adjustment for multiple confounding factors. In IS-stimulated osteocytes, mRNA and protein expression levels of DMP1 were significantly decreased compared with control osteocytes. We showed that low DMP1 levels were significantly associated with presence of vascular calcification and were independently associated with the incident cardiovascular events in prevalent peritoneal dialysis patients. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients. © 2016 American Society for Bone and Mineral Research.
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Low DMP1 blood levels have been associated with vascular calcification and higher risk of incident cardiovascular events in peritoneal dialysis patients.
“On the other hand, low DMP1 blood levels have been associated with vascular calcification and higher risk of incident cardiovascular events in peritoneal dialysis patients 42 .”
From Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues (2026) · cites this paper as [42]
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Citations
Cites
A New Equation to Estimate Glomerular Filtration Rate
Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00006 · Cited by 25,603
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950
FGF23 induces left ventricular hypertrophy
Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46122 · Cited by 2,027
Moe, S. M., Drüeke, T. B., Cunningham, J., Goodman, W. G., Martin, K. J., Ølgaard, K., Ott, S. M., Sprague, S. M., Lameire, N. H., & Eknoyan, G. (2006) · Kidney International · doi:10.1038/sj.ki.5000414 · Cited by 1,995
London, G. M. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg414 · Cited by 1,872
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · cited 1×
“Previous data showed that increased osteocyte apoptosis is a common feature in conditions of increased bone fragility including glucocorticoid excess,((32)) sex steroid deficiency,((33)) and decreased mechanical stimulation of the skeleton.”
BackgroundFeng, J. Q., Ward, L. M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S. I., Zhang, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1905 · Cited by 1,199 · cited 8×
“(49) FGF23, which is significantly elevated in patients with CKD or ESRD,(50) has been regarded as an important factor in deteriorating clinical outcomesvia vascular calcificationoruremic cardiomyopathy.”
BackgroundResultInfluentialNongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163
Demer, L. L., & Tintut, Y. (2008) · Circulation · doi:10.1161/circulationaha.107.743161 · Cited by 1,086
Tentori, F., Blayney, M. J., Albert, J. M., Gillespie, B. W., Kerr, P. G., Bommer, J., Young, E. W., Akizawa, T., Akiba, T., Pisoni, R. L., et al. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.03.020 · Cited by 1,077
Interpretation of Serum Calcium in Patients with Abnormal Serum Proteins
Payne, R. B., Little, A. J., Williams, R. B., & Milner, J. R. (1973) · BMJ · doi:10.1136/bmj.4.5893.643 · Cited by 949
Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease
Hu, M. C., Shi, M., Zhang, J., Quiñones, H., Griffith, C. S., Kuro‐o, M., & Moe, O. W. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009121311 · Cited by 945
Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia
Jonsson, K. B., Zahradnik, R. J., Larsson, T. E., White, K. E., Sugimoto, T., Imanishi, Y., Yamamoto, T., Hampson, G., Koshiyama, H., Ljunggren, Ö., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020881 · Cited by 904
Smooth Muscle Cell Phenotypic Transition Associated With Calcification
Steitz, S. A., Speer, M. Y., Curinga, G., Yang, H.-Y. L., Haynes, P. A., Aebersold, R. H., Schinke, T., Karsenty, G., & Giachelli, C. M. (2001) · Circulation Research · doi:10.1161/hh2401.101070 · Cited by 830
Kousteni, S. (2001) · Cell · doi:10.1016/s0092-8674(02)08100-x · Cited by 757
Kauppila, L. I., Polak, J. F., Cupples, L. A., Hannan, M. T., Kiel, D. P., & Wilson, P. W. F. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00106-8 · Cited by 730
US Renal Data System 2013 Annual Data Report
Collins, A. J., Foley, R. N., Chavers, B. M., Gilbertson, D. T., Herzog, C. A., Ishani, A., Johansen, K. L., Kasiske, B. L., Kutner, N. G., Liu, J., et al. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.11.001 · Cited by 691
Arterial Calcifications and Bone Histomorphometry in End-Stage Renal Disease
London, G. M., Marty, C., Marchais, S. J., Guérin, A. P., Métivier, F., & de Vernejoul, M. C. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000129337.50739.48 · Cited by 589
Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060107 · Cited by 494
The prognostic importance of left ventricular geometry in uremic cardiomyopathy.
Foley, R. N., Parfrey, P. S., Harnett, J. D., Kent, G. M., Murray, D. C., & Barré, P. E. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v5122024 · Cited by 480
Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals
Shao, J.-S., Cheng, S., Pingsterhaus, J. M., Charlton-Kachigian, N., Loewy, A. P., & Towler, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24140 · Cited by 459
Liu, W., Toyosawa, S., Furuichi, T., Kanatani, N., Yoshida, C. A., Liu, Y., Himeno, M., Narai, S., Yamaguchi, A., & Komori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105052 · Cited by 454
The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis
Razzaque, M. S. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.196 · Cited by 452
George, A., Sabsay, B., Simonian, P. A., & Veis, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31434-0 · Cited by 445
Progression of Aortic Calcification Is Associated With Metacarpal Bone Loss During Menopause
Hak, A. E., Pols, H. A. P., van Hemert, A. M., Albert Hofman, D., & Witteman, J. C. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1926 · Cited by 373
Stevens, L. A., Djurdjev, O., Cardew, S., Cameron, E. C., & Levin, A. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000113243.24155.2f · Cited by 352
Arterial calcification and bone physiology: role of the bone–vascular axis
Thompson, B., & Towler, D. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.36 · Cited by 347
Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification
Sun, Y., Byon, C. H., Yuan, K., Chen, J., Mao, X., Heath, J. M., Javed, A., Zhang, K., Anderson, P. G., & Chen, Y. (2012) · Circulation Research · doi:10.1161/circresaha.112.267237 · Cited by 344
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
Scialla, J. J., Lau, W. L., Reilly, M. P., Isakova, T., Yang, H.-Y. L., Crouthamel, M. H., Chavkin, N. W., Rahman, M., WAHL, P. W., Amaral, A. P., et al. (2013) · Kidney International · doi:10.1038/ki.2013.3 · Cited by 339
FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization
Quarles, L. D. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00016.2003 · Cited by 333
Genetos, D. C., Kephart, C. J., Zhang, Y., Yellowley, C. E., & Donahue, H. J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21021 · Cited by 328
Coronary artery calcification in patients with CRF not undergoing dialysis
Russo, D., Palmiero, G., Blasio, A. D., Balletta, M., & Andreucci, V. E. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.07.022 · Cited by 294
Dentine as a bioactive extracellular matrix
Smith, A. J., Scheven, B. A. A., Takahashi, Y., Ferracane, J. L., Shelton, R. M., & Cooper, P. R. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.07.008 · Cited by 294
Toyosawa, S., Shintani, S., Fujiwara, T., Ooshima, T., Sato, A., Ijuhin, N., & Komori, T. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.11.2017 · Cited by 288
Dentin matrix proteins: Composition and possible functions in calcification
Linde, A. (1989) · The Anatomical Record · doi:10.1002/ar.1092240206 · Cited by 267
Geoffroy, V., Kneissel, M., Fournier, B., BOYDE, A., & Matthias, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6222-6233.2002 · Cited by 263
on behalf of the European Uremic Toxin (EUTox) Work Group, Desjardins, L., Liabeuf, S., Renard, C., Lenglet, A., Lemke, H., Choukroun, G. J., Drüeke, T. B., & Massy, Z. A. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1838-0 · Cited by 219
DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
Ling, Y., Rios, H. F., Myers, E. R., Lu, Y., Feng, J. Q., & Boskey, A. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050815 · Cited by 216
FGF23 Fails to Inhibit Uremic Parathyroid Glands
Canalejo, R., Canalejo, A., Martinez-Moreno, J. M., Rodríguez-Ortiz, M. E., Estepa, J. C., Mendoza, F. J., Muñoz-Castañeda, J. R., Shalhoub, V., Almadén, Y., & Rodríguez, M. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009040427 · Cited by 195
Circulating α-Klotho Levels in CKD and Relationship to Progression
Kim, H. R., Nam, B. Y., Kim, D. W., Kang, M. W., Han, J.-H., Lee, M. J., Shin, D., Doh, F. M., Koo, H. M., Ko, K. I., et al. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.01.024 · Cited by 184
Self-citationBone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders
Vervloet, M. G., Massy, Z. A., Brandenburg, V. M., Mazzaferro, S., Cozzolino, M. G., Ureña, P., Bover, J., & Goldsmith, D. J. A. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70059-2 · Cited by 159
Dentin Matrix Protein 1, a Target Molecule for Cbfa1 in Bone, Is a Unique Bone Marker Gene
Feng, J. Q., Zhang, J., Dallas, S. L., Lu, Y., Chen, S., Tan, X., Owen, M. J., Harris, S. E., & MacDougall, M. J. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.10.1822 · Cited by 158
Farhat, G. N., Cauley, J. A., Matthews, K. A., Newman, A. B., Johnston, J. M., Mackey, R. H., Edmundowicz, D., & Sutton-Tyrrell, K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060903 · Cited by 142
Mori, K., Shioi, A., Jono, S., Nishizawà, Y., & Morii, H. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.9.2112 · Cited by 122
Kang, S., Adler, S. G., Nast, C. C., LaPage, J. A., Gu, J., Nadler, J. L., & Natarajan, R. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041354.x · Cited by 102
Self-citationLee, M. J., Lee, S. A., Nam, B. Y., Park, S., Lee, S., Ryu, H. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Oh, H. J., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.002 · Cited by 98
Self-citationExpression of dentin matrix protein 1 (DMP1) in nonmineralized tissues
Terasawa, M., Shimokawa, R., Terashima, T., Ohya, K., Takagi, Y., & Shimokawa, H. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0504-4 · Cited by 92
The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled
Rowe, P. S. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2841 · Cited by 72
Excess mortality among patients on dialysis: Comparison with the general population in Korea
Choi, H. Y., Kim, M., Kim, H., Lee, J. P., Lee, J., Park, J. T., Kim, K. H., Ahn, H. S., Hann, H. J., & Ryu, D. (2014) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2014.04.001 · Cited by 42
Self-citationLee, J., Yamaguchi, A., & Iimura, T. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2014.38 · Cited by 33
Predentin changes in patients with chronic renal failure
Wysocki, G. P., Daley, T. D., & Ulan, R. A. (1983) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(83)90284-0 · Cited by 25
Kwon, H. Y., Lee, O., Kim, M. J., Joo, W. C., Lee, S. Y., Kim, M., Song, J. H., & Lee, S. W. (2014) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2014.04.003 · Cited by 22
Mikami, Y., Takahashi, T., Kato, S., & Takagi, M. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.08.033 · Cited by 21
Krempien, B., Geiger, G., Ritz, E., & B�ttner, S. (1973) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00548653 · Cited by 20
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
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- 2014, American Diabetes Association. Standards of medical care in diabetes—2014. Diagnosis and classification of diabetes mellitus, Diabetes Care, 37, S14
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Dussold, C., Gerber, C., White, S., Wang, X., Qi, L., Francis, C., Capella, M., Courbon, G., Wang, J., Li, C., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0051-1 · Cited by 96
Bone and heart health in chronic kidney disease
Martin, A. (2019) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000512 · Cited by 13
Martin, A., & Kentrup, D. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00697-5 · Cited by 7
Vascular calcification inhibitors in chronic kidney disease
Adoberg, A., Leis, L., Luman, M., Uhlin, F., Fridolin, I., Viigimaa, M., & Holmar, J. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120271 · Cited by 5
Dai, L., Yang, Y., Liu, L., Long, C., Da, J., Chen, S., Zhao, J., Shen, Y., Huang, C., Zha, Y., et al. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2261786 · Cited by 4
Multifaceted skeletal effects of sevelamer carbonate in a secondary hyperparathyroidism model
Sharma, S., Kumar, S., Tomar, M. S., Chauhan, D., Sadhukhan, S., Kulkarni, C., Rajput, S., Porwal, K., Guha, R., Shrivastava, A., et al. (2025) · Endocrine · doi:10.1007/s12020-025-04180-4 · Cited by 3
Houessou, U., Zamani, P., Manikpurage, H. D., Li, Z., Gaudreault, N., Dahmene, M., Dagenais, F., Couture, C., Clavel, M.-A., Pibarot, P., et al. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120791 · Cited by 1
Toxic Effects of p-Cresyl sulfate and Indoxyl Sulfate on Bone: A Systematic Review
Narihan, M. Z. A., Jelani, A. F., Froemming, G. R. A., & Dayang, E.-Z. (2025) · Malaysian Journal of Medicine and Health Sciences · doi:10.47836/mjmhs.21.4.37
Metadata
- Authors
- Yoon, C.-Y., Park, J., Seo, C., Nam, B. Y., Kim, S., Kee, Y. K., Lee, M., Cha, M.-U., Kim, H., Park, S., Yun, H.-R., Jung, S.-Y., Jhee, J. H., Kwon, Y. E., Wu, M., Um, J. E., Kang, H.-Y., Park, J. T., Han, S. H., Kang, S.-W., Kim, H. C., Park, S., Lim, S.-K., & Yoo, T.-H.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Yoo, Tae-Hyun
- ORCID
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-08
- Volume
- 31
- Issue
- 12
- Pages
- 2149-2158
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2467413823
- Cited by
- 8
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2021: 1 · 2019: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Brain Korea 21 Project for Medical Science
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- DMP1, peritoneal dialysis, cardiovascular events, vascular calcification, indoxyl sulfate, osteocytes, chronic kidney disease-mineral and bone disorder, prognostic factors, end-stage renal disease, cardiovascular risk prediction
- MeSH terms
- Animals, Cardiovascular Diseases, Cell Line, Female, Humans, Indican, Male, Middle Aged, Osteocytes, Peritoneal Dialysis, Phosphoproteins, Risk Factors, RNA, Messenger, Incidence, Logistic Models, Proportional Hazards Models, Case-Control Studies, Extracellular Matrix Proteins, Mice, Kaplan-Meier Estimate, Vascular Calcification
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