The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Intraflagellar Transport and Cilia-Dependent Renal Disease: The Ciliary Hypothesis of Polycystic Kidney Disease
Abstract
Epithelial cells that line mammalian kidney nephrons have solitary nonmotile primary cilium projecting from their surface into the lumens of the ducts and tubules. Mutations that block the assembly of these cilia cause cystic kidney disease. The products of human autosomal dominant and recessive polycystic kidney disease genes and products of the nephronophthisis disease genes are at least partially localized to primary cilia. This suggests that the cilium serves as an organizing center for the early steps of the signal transduction pathway that is responsible for monitoring the integrity of the kidney nephron and controlling cell proliferation and differentiation.
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Citations
Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Proteomic characterization of the human centrosome by protein correlation profiling
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Self-citationA motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007
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The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly
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Self-citationCytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly in Chlamydomonas
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Cited by
Autosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
The Primary Cilium as a Complex Signaling Center
Berbari, N. F., O'Connor, A. K., Haycraft, C. J., & Yoder, B. K. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.025 · Cited by 621
Defective planar cell polarity in polycystic kidney disease
Fischer, E., Legue, E., Doyen, A., Nato, F., Nicolas, J.-F., Torres, V., Yaniv, M., & Pontoglio, M. (2006) · Nature Genetics · doi:10.1038/ng1701 · Cited by 537
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism
Malone, A. M. D., Anderson, C. T., Tummala, P., Kwon, R. Y., Johnston, T. R., Stearns, T., & Jacobs, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700636104 · Cited by 477
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
Bukanov, N. O., Smith, L. A., Klinger, K. W., Ledbetter, S. R., & Ibraghimov-Beskrovnaya, O. (2006) · Nature · doi:10.1038/nature05348 · Cited by 276
Metadata
- Authors
- Pazour, G. J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2004-10
- Volume
- 15
- Issue
- 10
- Pages
- 2528-2536
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2144273979
- Cited by
- 178
- References
- 9
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Intraflagellar Transport and Cilia-Dependent Renal Disease: The Ciliary Hypothesis of Polycystic Kidney Disease. https://app.cochat.ai/papers/10.1097/01.asn.0000141055.57643.e0
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- Pazour, G. J. (2004). Intraflagellar Transport and Cilia-Dependent Renal Disease: The Ciliary Hypothesis of Polycystic Kidney Disease. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000141055.57643.e0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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