Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725 · see citing works

Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization

Asahara, T., Masuda, H., Takahashi, T., Kalka, C., Pastore, C., Silver, M., Kearne, M., Magner, M., & Isner, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.3.221 · Cited by 3,249 · see citing works

Flow-mediated endothelial mechanotransduction

Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802 · see citing works

Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

Kocher, A. A., Schuster, M., Szabolcs, M., Takuma, S., Burkhoff, D., Wang, J., Homma, S., Edwards, N. M., & Itescu, S. (2001) · Nature Medicine · doi:10.1038/86498 · Cited by 2,537 · see citing works

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J. M., & Asahara, T. (1999) · Nature Medicine · doi:10.1038/7434 · Cited by 2,421 · see citing works

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

Peichev, M., Naiyer, A. J., Pereira, D., Zhu, Z., Lane, W. J., Williams, M., Oz, M., Hicklin, D. J., Witte, L., Moore, M. A. S., et al. (2000) · Blood · doi:10.1182/blood.v95.3.952.003k27_952_958 · Cited by 2,274 · see citing works

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057 · see citing works

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization

Kalka, C., Masuda, H., Takahashi, T., Kalka-Moll, W. M., Silver, M., Kearney, M., Li, T., Isner, J. M., & Asahara, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3422 · Cited by 1,862 · see citing works

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860 · see citing works

VEGF contributes to postnatal neovascularization by mobilizing bone marrow‐derived endothelial progenitor cells

Asahara, T., Takahashi, T., Masuda, H., Kalka, C., Chen, D., Iwaguro, H., Inai, Y., Silver, M., & Isner, J. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3964 · Cited by 1,856 · see citing works

AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells

Yin, A. H., Miraglia, S. J., Zanjani, E. D., Almeida-Porada, G. D., Ogawa, M., Leary, A. G., Olweus, J., Kearney, J. F., & Buck, D. W. (1997) · Blood · doi:10.1182/blood.v90.12.5002 · Cited by 1,821 · see citing works

Functional Arteries Grown in Vitro

Niklason, L. E., Gao, J., Abbott, W. M., Hirschi, K. K., Houser, S. L., Marini, R. P., & Langer, R. (1999) · Science · doi:10.1126/science.284.5413.489 · Cited by 1,767 · see citing works

Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors

Rehman, J., Li, J., Orschell, C. M., & March, K. L. (2003) · Circulation · doi:10.1161/01.cir.0000058702.69484.a0 · Cited by 1,682 · see citing works

Origins of circulating endothelial cells and endothelial outgrowth from blood

Lin, Y., Weisdorf, D. J., Solovey, A. N., & Hebbel, R. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8071 · Cited by 1,531 · see citing works

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

Carmeliet, P., Lampugnani, M. G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81010-7 · Cited by 1,284 · see citing works

The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

Singla, V., & Reiter, J. F. (2006) · Science · doi:10.1126/science.1124534 · Cited by 1,179 · see citing works

Origin of endothelial progenitors in human postnatal bone marrow

Reyes, M., Dudek, A. Z., Jahagirdar, B., Koodie, L., Marker, P. H., & Verfaillie, C. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14327 · Cited by 1,105 · see citing works

In vitro differentiation of endothelial cells from AC133-positive progenitor cells

Gehling, U. M., Ergün, S., Schumacher, U., Wagener, C., Pantel, K., Otte, M., Schuch, G., Schafhausen, P., Mende, T., Kilic, N., et al. (2000) · Blood · doi:10.1182/blood.v95.10.3106 · Cited by 1,015 · see citing works

Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress

Cheng, C., Tempel, D., van Haperen, R., van der Baan, A., Grosveld, F. G., Daemen, M. J. A. P., Krams, R., & de Crom, R. (2006) · Circulation · doi:10.1161/circulationaha.105.590018 · Cited by 1,002 · see citing works

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16

Dise, T. E. P. K. (1994) · Cell · doi:10.1016/0092-8674(94)90137-6 · Cited by 897 · see citing works

Transplanted cord blood–derived endothelial precursor cells augment postnatal neovascularization

Murohara, T., Ikeda, H., Duan, J., Shintani, S., Sasaki, K., Eguchi, H., Onitsuka, I., Matsui, K., & Imaizumi, T. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8296 · Cited by 892 · see citing works

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture.

Piperno, G., LeDizet, M., & Chang, X. J. (1987) · The Journal of cell biology · doi:10.1083/jcb.104.2.289 · Cited by 873 · see citing works

Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium

Prætorius, H. A., & Spring, K. R. (2001) · The Journal of Membrane Biology · doi:10.1007/s00232-001-0075-4 · Cited by 828 · see citing works

Cilia and Hedgehog responsiveness in the mouse

Huangfu, D., & Anderson, K. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505328102 · Cited by 820 · see citing works

The Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress

Levesque, M. J., & Nerem, R. M. (1985) · Journal of Biomechanical Engineering · doi:10.1115/1.3138567 · Cited by 724 · see citing works

Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

Hattori, K., Dias, S., Heissig, B., Hackett, N. R., Lyden, D. C., Tateno, M., Hicklin, D. J., Zhu, Z., Witte, L., Crystal, R. G., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1005 · Cited by 685 · see citing works

Intramyocardial Transplantation of Autologous Endothelial Progenitor Cells for Therapeutic Neovascularization of Myocardial Ischemia

Kawamoto, A., Tkebuchava, T., Yamaguchi, J.-I., Nishimura, H., Yoon, Y., Milliken, C., Uchida, S., Masuo, O., Iwaguro, H., Ma, H., et al. (2003) · Circulation · doi:10.1161/01.cir.0000046450.89986.50 · Cited by 648 · see citing works

PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts

Schneider, L., Clement, C. A., Teilmann, S. C., Pazour, G. J., Hoffmann, E. K., Satir, P., & Christensen, S. T. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.012 · Cited by 592 · see citing works

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

Lin, F., Hiesberger, T., Cordes, K. R., Sinclair, A. M., Goldstein, L. S. B., Somlo, S., & Igarashi, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0836980100 · Cited by 588 · see citing works

Mechanotransduction in Response to Shear Stress

Chen, K., Li, Y.-S. J., Kim, M. S., Li, S., Yuan, S., Chien, S., & Shyy, J. Y.-J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18393 · Cited by 564 · see citing works

Vascular Endothelial Growth Factor 165 Gene Transfer Augments Circulating Endothelial Progenitor Cells in Human Subjects

Kalka, C., Masuda, H., Takahashi, T., Gordon, R., Tepper, O. M., Gravereaux, E. C., Pieczek, A., Iwaguro, H., Hayashi, S.-I., Isner, J. M., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1198 · Cited by 564 · see citing works

Cell mechanics and mechanotransduction: pathways, probes, and physiology

Huang, H., Kamm, R. D., & Lee, R. T. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00559.2003 · Cited by 548 · see citing works

Cyclo-Oxygenase 2 Function Is Essential for Bone Fracture Healing

Simon, A. M., Manigrasso, M. B., & O’Connor, J. P. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.6.963 · Cited by 537 · see citing works

The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly

Follit, J. A., Tuft, R. A., Fogarty, K. E., & Pazour, G. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0133 · Cited by 499 · see citing works

Circulating endothelial precursors: mystery, reality, and promise

Rafii, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8774 · Cited by 434 · see citing works

Intraflagellar transport is essential for endochondral bone formation

Haycraft, C. J., Zhang, Q., Song, B., Jackson, W. S., Detloff, P. J., Serra, R. A., & Yoder, B. K. (2006) · Development · doi:10.1242/dev.02732 · Cited by 395 · see citing works

Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3–E1 Osteoblasts

You, J., Reilly, G. C., Zhen, X., Yellowley, C. E., Chen, Q., Donahue, H. J., & Jacobs, C. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009846200 · Cited by 390 · see citing works

Selective targeting of somatostatin receptor 3 to neuronal cilia

Händel, M., Schulz, S., Stanarius, A., Schreff, M., Erdtmann-Vourliotis, M., Schmidt, H., Wolf, G. L., & Höllt, V. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00354-6 · Cited by 380 · see citing works

Expression of primary cilia in mammalian cells

WHEATLEY, D. N., WANG, A. M., & STRUGNELL, G. E. (1996) · Cell Biology International · doi:10.1006/cbir.1996.0011 · Cited by 378 · see citing works

Physical Activity in the Prevention and Amelioration of Osteoporosis in Women

Borer, K. T. (2005) · Sports Medicine · doi:10.2165/00007256-200535090-00004 · Cited by 372 · see citing works

Polycystin-1, STAT6, and P100 Function in a Pathway that Transduces Ciliary Mechanosensation and Is Activated in Polycystic Kidney Disease

Low, S. H., Vasanth, S., Larson, C. H., Mukherjee, S., Sharma, N., Kinter, M. T., Kane, M. E., Obara, T., & Weimbs, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.005 · Cited by 364 · see citing works

Removal of the MDCK Cell Primary Cilium Abolishes Flow Sensing

Prætorius, H. A., & Spring, K. R. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-002-1042-4 · Cited by 345 · see citing works

Endothelial-like cells derived from human CD14 positive monocytes

Pujol, B. F., Lucibello, F. C., Gehling, U. M., Lindemann, K., Weidner, N., Zuzarte, M., Adamkiewicz, J., Elsässer, H., Müller, R., & HAVEMANN, K. (2000) · Differentiation · doi:10.1046/j.1432-0436.2000.6550287.x · Cited by 342 · see citing works

MLO-Y4 Osteocyte-Like Cells Support Osteoclast Formation and Activation

Zhao, S., Kato, Y., Zhang, Y., Harris, S., Ahuja, S. S., & Bonewald, L. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.2068 · Cited by 322 · see citing works

De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia

Nonaka, S., Yoshiba, S., Watanabe, D., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030268 · Cited by 320 · see citing works

Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress

Yamamoto, K., Takahashi, T., Asahara, T., Ohura, N., Sokabe, T., Kamiya, A., & Ando, J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00232.2003 · Cited by 316 · see citing works

Ca2+regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

Chen, N. X., Ryder, K. D., Pavalko, F. M., Turner, C. H., Burr, D. B., Qiu, J., & Duncan, R. L. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.5.c989 · Cited by 293 · see citing works

Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them Into Intracellular Ca2+ and cAMP Signaling

Masyuk, A. I., Masyuk, T. V., Splinter, P. L., Huang, B. Q., Stroope, A. J., & LaRusso, N. F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.003 · Cited by 293 · see citing works

CD34−Blood‐Derived Human Endothelial Cell Progenitors

Harraz, M. M., Jiao, C., Hanlon, H. D., et al. (2001) · Stem Cells · doi:10.1634/stemcells.19-4-304 · Cited by 289 · see citing works

Mobilization of Endothelial and Hematopoietic Stem and Progenitor Cells by Adenovector‐Mediated Elevation of Serum Levels of SDF‐1, VEGF, and Angiopoietin‐1

Moore, M. A. S., Hattori, K., Heissig, B., et al. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03572.x · Cited by 289 · see citing works

A novel molecular mechanism modulating osteoclast differentiation and function

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Goto, M., Mochizuki, S.-I., Tsuda, E., Morinaga, T., Udagawa, N., et al. (1999) · Bone · doi:10.1016/s8756-3282(99)00121-0 · Cited by 262 · see citing works

Laminar Shear Stress Inhibits Vascular Endothelial Cell Proliferation by Inducing Cyclin-Dependent Kinase Inhibitor p21 Sdi1/Cip1/Waf1

Akimoto, S., Mitsumata, M., Sasaguri, T., & Yoshida, Y. (2000) · Circulation Research · doi:10.1161/01.res.86.2.185 · Cited by 260 · see citing works

Functional Gap Junctions Between Osteocytic and Osteoblastic Cells

Yellowley, C. E., Li, Z., Zhou, Z., Jacobs, C. R., & Donahue, H. J. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.2.209 · Cited by 259 · see citing works

Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

Xiao, Z., Zhang, S., Mahlios, J., Zhou, G., Magenheimer, B. S., Guo, D., Dallas, S. L., Maser, R., Calvet, J. P., Bonewald, L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604772200 · Cited by 254 · see citing works

Transient and Steady-State Effects of Shear Stress on Endothelial Cell Adherens Junctions

Noria, S. F., Cowan, D. B., Gotlieb, A. I., & Langille, B. L. (1999) · Circulation Research · doi:10.1161/01.res.85.6.504 · Cited by 252 · see citing works

Functional Roles for PECAM-1 (CD31) and VE-Cadherin (CD144. in Tube Assembly and Lumen Formation in Three-Dimensional Collagen Gels

Yang, S., Graham, J., Kahn, J. W., Schwartz, E. A., & Gerritsen, M. E. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65188-7 · Cited by 251 · see citing works

Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes

Zenobi‐Wong, M., Siegrist, M., & Goodwin, K. (2003) · Bone · doi:10.1016/s8756-3282(03)00242-4 · Cited by 242 · see citing works

Polaris, a protein disrupted inorpkmutant mice, is required for assembly of renal cilium

Yoder, B. K., Tousson, A., Millican, L., Wu, J. H., Bugg, C. E., Schafer, J. A., Balkovetz, D. F., & Watkins), (. T. T. A. O. L. L. A. M. L. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00273.2001 · Cited by 240 · see citing works

Targeted null-mutation in the vascular endothelial–cadherin gene impairs the organization of vascular-like structures in embryoid bodies

Vittet, D., Buchou, T., Schweitzer, A., Dejana, E., & Huber, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6273 · Cited by 227 · see citing works

Response of cultured endothelial cells to steady flow

Eskin, S. G., Ives, C. L., McIntire, L. V., & Navarro, L. T. (1984) · Microvascular Research · doi:10.1016/0026-2862(84)90031-1 · Cited by 215 · see citing works

In situ measurement of solute transport in the bone lacunar-canalicular system

Wang, L., Wang, Y., Han, Y., Henderson, S. C., Majeska, R. J., Weinbaum, S., & Schaffler, M. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505193102 · Cited by 214 · see citing works

VE-Cadherin Mediates Endothelial Cell Capillary Tube Formation in Fibrin and Collagen Gels1

Bach, T. L., Barsigian, C., Chalupowicz, D. G., Busler, D. E., Yaen, C. H., Grant, D. S., & Martinez, J. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3844 · Cited by 211 · see citing works

Polycystin 2 Interacts with Type I Inositol 1,4,5-Trisphosphate Receptor to Modulate Intracellular Ca2+ Signaling

Li, Y., Wright, J. M., Qian, F., Germino, G. G., & Guggino, W. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510082200 · Cited by 195 · see citing works

Localization of Extracellular Matrix Receptors on the Chondrocyte Primary Cilium

McGlashan, S. R., Jensen, C. G., & Poole, C. A. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6866.2006 · Cited by 191 · see citing works

Modeling Interstitial Flow in an Artery Wall Allows Estimation of Wall Shear Stress on Smooth Muscle Cells

Wang, D. M., & Tarbell, J. M. (1995) · Journal of Biomechanical Engineering · doi:10.1115/1.2794192 · Cited by 188 · see citing works

PGE2 Is Essential for Gap Junction-Mediated Intercellular Communication between Osteocyte-Like MLO-Y4 Cells in Response to Mechanical Strain

Cheng, B., Kato, Y., Zhao, S., Luo, J., Sprague, E. A., Bonewald, L. F., & Jiang, J. X. (2001) · Endocrinology · doi:10.1210/endo.142.8.8338 · Cited by 186 · see citing works

Centrosome number is controlled by a centrosome-intrinsic block to reduplication

Wong, C., & Stearns, T. (2003) · Nature Cell Biology · doi:10.1038/ncb993 · Cited by 185 · see citing works

The effect of fluid shear stress on the migration and proliferation of cultured endothelial cells

Ando, J., Nomura, H., & Kamiya, A. (1987) · Microvascular Research · doi:10.1016/0026-2862(87)90007-0 · Cited by 184 · see citing works

Intraflagellar Transport and Cilia-Dependent Renal Disease

Pazour, G. J. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141055.57643.e0 · Cited by 178 · see citing works

The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin

Shen, Q., & Christakos, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504166200 · Cited by 173 · see citing works

Endochondral growth in growth plates of three species at two anatomical locations modulated by mechanical compression and tension

Stokes, I. A. F., Aronsson, D. D., Dimock, A. N., et al. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20189 · Cited by 166 · see citing works

Mechanoregulation of intracellular Ca2+concentration is attenuated in collecting duct of monocilium-impairedorpkmice

Liu, W., Murcia, N. S., Duan, Y., Weinbaum, S., Yoder, B. K., Schwiebert, E. M., & Satlin, L. M. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00260.2004 · Cited by 161 · see citing works

Signal Transduction and Mechanical Stress

Hughes‐Fulford, M. (2004) · Science s STKE · doi:10.1126/stke.2492004re12 · Cited by 157 · see citing works

Bending the Primary Cilium Opens Ca2+-sensitive Intermediate-Conductance K+ Channels in MDCK Cells

Prætorius, H. A., Frøkiær, J., Nielsen, S. S., & Spring, K. R. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-002-1055-z · Cited by 145 · see citing works

Hypoxic Preconditioning Augments Efficacy of Human Endothelial Progenitor Cells for Therapeutic Neovascularization

Akita, T., Murohara, T., Ikeda, H., et al. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000050761.67879.e4 · Cited by 143 · see citing works

Polycystic kidney disease: Cell division without a c(l)ue?

Simons, M., & Walz, G. (2006) · Kidney International · doi:10.1038/sj.ki.5001534 · Cited by 141 · see citing works

Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling

Kim, C. H., You, L., Yellowley, C. E., & Jacobs, C. R. (2006) · Bone · doi:10.1016/j.bone.2006.05.017 · Cited by 139 · see citing works

Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells

Ohta, T., Essner, R., Ryu, J.-H., Palazzo, R. E., Uetake, Y., & Kuriyama, R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108088 · Cited by 136 · see citing works

Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization

Rabbany, S. Y., Heissig, B., Hattori, K., & Rafii, S. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00021-2 · Cited by 133 · see citing works

Effects of Fluid Flow on Living Vascular Cells

Dewey, C. F. (1984) · Journal of Biomechanical Engineering · doi:10.1115/1.3138453 · Cited by 130 · see citing works

The Emerging Role of the Bone Marrow-Derived Stem Cells in (Therapeutic) Angiogenesis

Luttun, A., & Carmeliet, P. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616226 · Cited by 126 · see citing works

Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication

Donahue, H. J., Li, Z., Zhou, Z., & Yellowley, C. E. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.2.c315 · Cited by 116 · see citing works

Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation.

Nagai, M., & Sato, N. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0524 · Cited by 111 · see citing works

Fluid flow induced PGE 2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not

Reilly, G. C., Haut, T. R., Yellowley, C. E., Donahue, H. J., & Jacobs, C. R. (2003) · Biorheology · doi:10.1177/0006355x2003040006005 · Cited by 106 · see citing works

In situ microdialysis in bone tissue. Stimulation of prostaglandin E2 release by weight-bearing mechanical loading.

Thorsen, K., Kristoffersson, A. O., Lerner, U. H., & Lorentzon, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119061 · Cited by 95 · see citing works

Fluid Shear Stress Increases the Production of Granulocyte-Macrophage Colony-Stimulating Factor by Endothelial Cells via mRNA Stabilization

Kosaki, K., Ando, J., Korenaga, R., et al. (1998) · Circulation Research · doi:10.1161/01.res.82.7.794 · Cited by 93 · see citing works

Formation of focal adhesions on fibronectin promotes fluid shear stress induction of COX-2 and PGE2release in MC3T3-E1 osteoblasts

Ponik, S. M., & Pavalko, F. M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01260.2003 · Cited by 92 · see citing works

Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells

Siroky, B. J., Ferguson, W. B., Fuson, A. L., Xie, Y., Fintha, A., Komlósi, P., Yoder, B. K., Schwiebert, E. M., Guay‐Woodford, L. M., & Bell, P. D. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00463.2005 · Cited by 92 · see citing works

Primary cilium—is it an osteocyte's strain‐sensing flowmeter?

Whitfield, J. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10509 · Cited by 90 · see citing works

Flexible-substratum technique for viewing cells from the side: Some in vivo properties of primary (9+0) cilia in cultured kidney epithelia

Roth, K. E., Rieder, C. L., & Bowser, S. S. (1988) · Journal of Cell Science · doi:10.1242/jcs.89.4.457 · Cited by 87 · see citing works

Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium

Saunders, M. M., You, J., Zhou, Z., Li, Z., Yellowley, C. E., Kunze, E. L., Jacobs, C. R., & Donahue, H. J. (2003) · Bone · doi:10.1016/s8756-3282(03)00025-5 · Cited by 86 · see citing works

The Influence of Shear Stress on Cultured Vascular Endothelial Cells: The Stress Response of an Anchorage‐Dependent Mammalian Cell

Levesque, M. J., Sprague, E. A., Schwartz, C. J., et al. (1989) · Biotechnology Progress · doi:10.1002/btpr.5420050105 · Cited by 86 · see citing works

Increase in endothelial cell density before artery enlargement in flow-loaded canine carotid artery.

Masuda, H., Kawamura, K., Tohda, K., et al. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.6.812 · Cited by 80 · see citing works

Focal Adhesion Kinase Expression during Mandibular Distraction Osteogenesis: Evidence for Mechanotransduction

Tong, L. C., Buchman, S. R., Ignelzi, M. A., Rhee, S. T., & Goldstein, S. A. (2003) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000033180.01581.9a · Cited by 72 · see citing works

Vertebrate primary cilia: a sensory part of centrosomal complex in tissue cells, but a “sleeping beauty” in cultured cells?

Alieva, I. B., & Vorobjev, I. A. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.11.013 · Cited by 71 · see citing works

A finite difference model of load-induced fluid displacements within bone under mechanical loading

Steck, R., Niederer, P. F., & Tate, M. L. K. (2000) · Medical Engineering & Physics · doi:10.1016/s1350-4533(00)00017-5 · Cited by 45 · see citing works

Electron Microscopy of Aging Skeletal Cells. I. Centrioles and Solitary Cilia

TONNA, E. A., & Lampen, N. M. (1972) · Journal of Gerontology · doi:10.1093/geronj/27.3.316 · Cited by 43 · see citing works

Chloral hydrate alters the organization of the ciliary basal apparatus and cell organelles in sea urchin embryos

Chakrabarti, A., Schatten, H., Mitchell, K. D., et al. (1998) · Cell and Tissue Research · doi:10.1007/s004410051137 · Cited by 32 · see citing works

A disk-type apparatus for applying fluid shear stress on cultured endothelial cell

Nomura, H., Ishikawa, C., Komatsuda, T., Ando, J., & Kamiya, A. (1988) · Biorheology · doi:10.3233/bir-1988-25307 · Cited by 28 · see citing works

Fluid shear stress enhanced DNA synthesis in cultured endothelial cells during repair of mechanical denudation

Ando, J., Komatsuda, T., Ishikawa, C., et al. (1990) · Biorheology · doi:10.3233/bir-1990-27505 · Cited by 28 · see citing works

Thrombin increases cytoplasmic Ca2+ and stimulates formation of prostaglandin E2 in the osteoblastic cell line MC3T3-El

Ljunggren, Ö., Johansson, H. E., Ljunghall, S., et al. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90037-z · Cited by 26 · see citing works

Chloral hydrate disrupts mitosis by increasing intracellular free calcium

Lee, G. M., DiGuiseppi, J., Gawdi, G., et al. (1987) · Journal of Cell Science · doi:10.1242/jcs.88.5.603 · Cited by 24 · see citing works

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works

Osteocytes, mechanosensing and Wnt signaling

Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076 · see citing works

The Osteocyte: An Endocrine Cell … and More

Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works

Mechanical regulation of bone remodeling

Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641 · see citing works

Mechanisms of Tooth Eruption and Orthodontic Tooth Movement

Wise, G. E., & King, G. J. (2008) · Journal of Dental Research · doi:10.1177/154405910808700509 · Cited by 581 · see citing works

Biomechanics and Mechanobiology of Trabecular Bone: A Review

Oftadeh, R., Perez‐Viloria, M., Villa‐Camacho, J. C., Vaziri, A., & Nazarian, A. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4029176 · Cited by 554 · see citing works

Mechanosensation and transduction in osteocytes

Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528 · see citing works

Osteocytes: master orchestrators of bone

Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514 · see citing works

Molecular mechanosensors in osteocytes

Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484 · see citing works

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

Mechanobiology and Developmental Control

Mammoto, T., Mammoto, A., & Ingber, D. E. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122340 · Cited by 436 · see citing works

Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain bone

Chen, J., Liu, C., You, L., & Simmons, C. A. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.016 · Cited by 424 · see citing works

Mechanical regulation of signaling pathways in bone

Thompson, W. R., Rubin, C. T., & Rubin, J. E. (2012) · Gene · doi:10.1016/j.gene.2012.04.076 · Cited by 410 · see citing works

Investigating cell mechanics with atomic force microscopy

Haase, K., & Pelling, A. E. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0970 · Cited by 397 · see citing works

Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction

Fritton, S. P., & Weinbaum, S. (2008) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fluid.010908.165136 · Cited by 383 · see citing works

The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth

Duan, P., & Bonewald, L. F. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.05.015 · Cited by 374 · see citing works

Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton

Klein‐Nulend, J., Bacabac, R. G., & Bakker, A. D. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a20 · Cited by 338 · see citing works

Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade

Li, Y., Zhan, Q., Bao, M., Li, Y., & Li, Y. (2021) · International Journal of Oral Science · doi:10.1038/s41368-021-00125-5 · Cited by 335 · see citing works

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

Phan, M. N., Leddy, H. A., Votta, B. J., Kumar, S., Levy, D. S., Lipshutz, D. B., Lee, S. H., Liedtke, W., & Guilak, F. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24799 · Cited by 308 · see citing works

In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation

Wittkowske, C., Reilly, G. C., Lacroix, D. J., & Perrault, C. M. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2016.00087 · Cited by 289 · see citing works

Osteocyte: the unrecognized side of bone tissue

Rochefort, G. Y., Pallu, S., & Benhamou, C. L. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1194-5 · Cited by 268 · see citing works

Stimulation of bone repair with ultrasound: A review of the possible mechanic effects

Padilla, F. R., Puts, R., Vico, L., & Raum, K. (2014) · Ultrasonics · doi:10.1016/j.ultras.2014.01.004 · Cited by 234 · see citing works

Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development

Li, H., Xiao, Z., Quarles, L. D., & Li, W. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200330142432 · Cited by 226 · see citing works

Effect of isolation methodology on stem cell properties and multilineage differentiation potential of human dental pulp stem cells

Hilkens, P., Gervois, P., Fanton, Y., Vanormelingen, J., Martens, W., Struys, T., Politis, C., Lambrichts, I., & Bronckaers, A. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1630-x · Cited by 230 · see citing works

Biomechanics and mechanobiology of the bone matrix

Ma, C., Du, T., Niu, X., & Fan, Y. (2022) · Bone Research · doi:10.1038/s41413-022-00223-y · Cited by 214 · see citing works

Primary cilia mediate mechanotransduction through control of ATP‐induced Ca 2+ signaling in compressed chondrocytes

Wann, A. K. T., Zuo, N., Haycraft, C. J., Jensen, C. G., Poole, C. A., McGlashan, S. R., & Knight, M. M. (2012) · The FASEB Journal · doi:10.1096/fj.11-193649 · Cited by 206 · see citing works

Osteocyte Mechanobiology and Pericellular Mechanics

Jacobs, C. R., Temiyasathit, S., & Castillo, A. B. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105302 · Cited by 197 · see citing works

Primary Cilia‐Mediated Mechanotransduction in Human Mesenchymal Stem Cells

Hoey, D. A., Tormey, S., Ramcharan, S., et al. (2012) · Stem Cells · doi:10.1002/stem.1235 · Cited by 181 · see citing works

Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization

Ma, Q., Miri, Z., Haugen, H. J., Moghanian, A., & Loca, D. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231172573 · Cited by 181 · see citing works

Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network

Schneider, P., Meier, M., Wepf, R. A., & Müller, R. (2010) · Bone · doi:10.1016/j.bone.2010.07.026 · Cited by 174 · see citing works

From mechanical stimulus to bone formation: A review

Rosa, N., Simões, R., Magalhães, F. D., & Marques, A. T. (2015) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2015.05.015 · Cited by 165 · see citing works

Disuse Osteoporosis: Clinical and Mechanistic Insights

Rolvien, T., & Amling, M. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00836-1 · Cited by 170 · see citing works

Primary Cilia Are Decreased in Breast Cancer: Analysis of a Collection of Human Breast Cancer Cell Lines and Tissues

Yuan, K., Frolova, N., Xie, Y., Wang, D., Cook, L. M., Kwon, Y.-J., Steg, A. D., Serra, R. A., & Frost, A. R. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955856 · Cited by 162 · see citing works

Mechanotransduction in the renal tubule

Weinbaum, S., Duan, Y., Satlin, L. M., Wang, T., & Weinstein, A. M. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00453.2010 · Cited by 158 · see citing works

Gap junctions and hemichannels in signal transmission, function and development of bone

Batra, N. R., Kar, R., & Jiang, J. X. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.09.018 · Cited by 157 · see citing works

From streaming‐potentials to shear stress: 25 years of bone cell mechanotransduction

Riddle, R. C., & Donahue, H. J. (2009) · Journal of Orthopaedic Research · doi:10.1002/jor.20723 · Cited by 157 · see citing works

Osteocyte primary cilium and its role in bone mechanotransduction

Temiyasathit, S., & Jacobs, C. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05243.x · Cited by 154 · see citing works

Mesenchymal stem cell responses to mechanical stimuli.

Delaine‐Smith, R. M., & Reilly, G. C. (2012) · PubMed · Cited by 154 · see citing works

Cell cycle progression by the repression of primary cilia formation in proliferating cells

Goto, H., Inoko, A., & Inagaki, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1302-8 · Cited by 153 · see citing works

Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis

Klein‐Nulend, J., van Oers, R. F. M., Bakker, A. D., & Bacabac, R. G. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.12.007 · Cited by 153 · see citing works

Muscle-bone interactions: From experimental models to the clinic? A critical update

Laurent, M. R., Dubois, V., Claessens, F., Verschueren, S., Vanderschueren, D., Gielen, E., & Jardí, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.017 · Cited by 152 · see citing works

Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

Shinohara, K., Kawasumi, A., Takamatsu, A., Yoshiba, S., Botilde, Y., Motoyama, N., Reith, W., Durand, B., Shiratori, H., & Hamada, H. (2012) · Nature Communications · doi:10.1038/ncomms1624 · Cited by 151 · see citing works

Mechanically induced osteogenic lineage commitment of stem cells

Chen, J. C., & Jacobs, C. R. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt318 · Cited by 150 · see citing works

The primary cilium functions as a mechanical and calcium signaling nexus

Lee, K. L., Guevarra, M. D., Nguyen, A. M., Chua, M., Wang, Y., & Jacobs, C. R. (2015) · Cilia · doi:10.1186/s13630-015-0016-y · Cited by 149 · see citing works

Chapter 5 Targeting Proteins to the Ciliary Membrane

Pazour, G. J., & Bloodgood, R. A. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00805-3 · Cited by 145 · see citing works

Primary cilia signaling mediates intraocular pressure sensation

Luo, N., Conwell, M. D., Chen, X., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323292111 · Cited by 146 · see citing works

Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins

Rachel, R. A., Li, T., & Swaroop, A. (2012) · Cilia · doi:10.1186/2046-2530-1-22 · Cited by 147 · see citing works

Primary cilium‐dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

Kwon, R. Y., Temiyasathit, S., Tummala, P., Quah, C. C., & Jacobs, C. R. (2010) · The FASEB Journal · doi:10.1096/fj.09-148007 · Cited by 144 · see citing works

The role of hedgehog signalling in skeletal health and disease

Alman, B. A. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.84 · Cited by 141 · see citing works

Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials

Pampaloni, F., & Florin, E. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.03.002 · Cited by 140 · see citing works

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

Wann, A. K. T., & Knight, M. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0980-y · Cited by 139 · see citing works

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

Ryskamp, D. A., Frye, A. M., Phuong, T. T. T., Yarishkin, O., Jo, A. O., Xu, Y., Lakk, M., Iuso, A., Redmon, S. N., Ambati, B., et al. (2016) · Scientific Reports · doi:10.1038/srep30583 · Cited by 139 · see citing works

Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

Yuan, X., Cao, J., He, X., Serra, R., Qu, J., Cao, X., & Yang, S. (2016) · Nature Communications · doi:10.1038/ncomms11024 · Cited by 122 · see citing works

Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia

Su, S. H., Phua, S. C., DeRose, R., Chiba, S., Narita, K., Kalugin, P. N., Katada, T., Kontani, K., Takeda, S., & Inoue, T. (2013) · Nature Methods · doi:10.1038/nmeth.2647 · Cited by 128 · see citing works

From Central to Rudimentary to Primary: The History of an Underappreciated Organelle Whose Time Has Come.The Primary Cilium

Bloodgood, R. A. (2009) · Methods in cell biology · doi:10.1016/s0091-679x(08)94001-2 · Cited by 122 · see citing works

Mechanosensing by the Primary Cilium: Deletion of Kif3A Reduces Bone Formation Due to Loading

Temiyasathit, S., Tang, W. J., Leucht, P., Anderson, C. T., Monica, S. D., Castillo, A. B., Helms, J. A., Stearns, T., & Jacobs, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033368 · Cited by 119 · see citing works

The mechanics of the primary cilium: An intricate structure with complex function

Hoey, D. A., Downs, M. E., & Jacobs, C. R. (2011) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2011.08.008 · Cited by 121 · see citing works

Osteoimmunology in Periodontitis and Orthodontic Tooth Movement

Alghamdi, B., Jeon, H. H., Ni, J., Qiu, D., Liu, A., Hong, J. J., Ali, M., Wang, A., Troka, M. E., & Graves, D. T. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00774-x · Cited by 129 · see citing works

The extracellular matrix and ciliary signaling

Seeger-Nukpezah, T., & Golemis, E. A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.06.002 · Cited by 117 · see citing works

Primary cilia: Cell and molecular mechanosensors directing whole tissue function

Spasić, M. R., & Jacobs, C. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.036 · Cited by 117 · see citing works

A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells

Hoey, D. A., Kelly, D. J., & Jacobs, C. R. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.072 · Cited by 115 · see citing works

Emerging role of primary cilia as mechanosensors in osteocytes

Nguyen, A. M., & Jacobs, C. R. (2012) · Bone · doi:10.1016/j.bone.2012.11.016 · Cited by 113 · see citing works

The role of osteocytes in bone mechanotransduction

Santos, A., Bakker, A. D., & Klein‐Nulend, J. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0858-5 · Cited by 109 · see citing works

Odontoblast: a mechano‐sensory cell

Magloire, H., Couble, M., Thivichon‐Prince, B., Maurin, J., & Bleicher, F. (2008) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21264 · Cited by 109 · see citing works

Evidence for pleiotropic factors in genetics of the musculoskeletal system

Karasik, D., & Kiel, D. P. (2010) · Bone · doi:10.1016/j.bone.2010.01.382 · Cited by 109 · see citing works

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells

McMurray, R. J., Wann, A. K. T., Thompson, C. L., Connelly, J. T., & Knight, M. M. (2013) · Scientific Reports · doi:10.1038/srep03545 · Cited by 106 · see citing works

Developmental and regenerative paradigms of cilia regulated hedgehog signaling

Kopinke, D., Norris, A. M., & Mukhopadhyay, S. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.029 · Cited by 104 · see citing works

Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton

Yuan, X., Serra, R. A., & Yang, S. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12463 · Cited by 105 · see citing works

The molecular basis of bone mechanotransduction.

Yavropoulou, M. P., & Yovos, J. G. (2016) · PubMed Central · Cited by 105 · see citing works

Cellular and Molecular Mechanisms of Dental Nociception

Chung, G., Jung, S. J., & Oh, S. B. (2013) · Journal of Dental Research · doi:10.1177/0022034513501877 · Cited by 99 · see citing works

Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

Liu, P., Tu, J., Wang, W., Li, Z., Li, Y., Yu, X., & Zhang, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.830722 · Cited by 99 · see citing works

Bone targeting for the treatment of osteoporosis

Lühmann, T. C., Germershaus, O., Gröll, J., & Meinel, L. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.10.001 · Cited by 98 · see citing works

Lengthening primary cilia enhances cellular mechanosensitivity

Spasić, M. R., & Jacobs, C. R. (2017) · European Cells and Materials · doi:10.22203/ecm.v033a12 · Cited by 95 · see citing works

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

Qiu, N., Xiao, Z., Cao, L., Buechel, M. M., David, V., Roan, E., & Quarles, L. D. (2012) · Journal of Cell Science · doi:10.1242/jcs.095893 · Cited by 96 · see citing works

Activation of Hedgehog Signaling Inhibits Osteoblast Differentiation of Human Mesenchymal Stem Cells

Plaisant, M., Fontaine, C., Cousin, W., Rochet, N., Dani, C., & Peraldi, P. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0888 · Cited by 92 · see citing works

Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia

Vaughan, T. J., Mullen, C. A., Verbruggen, S. W., & McNamara, L. M. (2014) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-014-0631-3 · Cited by 91 · see citing works

Physiology of Bone

Grabowski, P. (2009) · Endocrine development · doi:10.1159/000223687 · Cited by 89 · see citing works

Primary cilia respond to fluid shear stress and mediate flow‐induced calcium deposition in osteoblasts

Delaine‐Smith, R. M., Sittichokechaiwut, A., & Reilly, G. C. (2013) · The FASEB Journal · doi:10.1096/fj.13-231894 · Cited by 89 · see citing works

Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis

Mei, X., Middleton, K., Shim, D., Wan, Q., Xu, L., Ma, Y.-H. V., Devadas, D., Walji, N., Wang, L., Young, E. W. K., et al. (2019) · Integrative Biology · doi:10.1093/intbio/zyz008 · Cited by 88 · see citing works

Osteocytes and Estrogen Deficiency

McNamara, L. M. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00702-x · Cited by 88 · see citing works

Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice

Kwon, R. Y., Meays, D. R., Tang, W. J., & Frangos, J. A. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.74 · Cited by 84 · see citing works

Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation

Moore, E. R., Zhu, Y. X., Ryu, H.-S., & Jacobs, C. R. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0930-1 · Cited by 86 · see citing works

Chapter 11 Cilia Involvement in Patterning and Maintenance of the Skeleton

Haycraft, C. J., & Serra, R. A. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00811-9 · Cited by 86 · see citing works

The cilium as a force sensor−myth versus reality

Ferreira, R. R., Fukui, H., Chow, R., Vilfan, A., & Vermot, J. (2019) · Journal of Cell Science · doi:10.1242/jcs.213496 · Cited by 86 · see citing works

Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes

Shao, Y. Y., Wang, L., Welter, J. F., & Ballock, R. T. (2011) · Bone · doi:10.1016/j.bone.2011.08.033 · Cited by 84 · see citing works

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

Kim, D., Chambliss, A. B., & Wirtz, D. (2013) · Soft Matter · doi:10.1039/c3sm50798j · Cited by 83 · see citing works

Mechanistic Insight into Orthodontic Tooth Movement Based on Animal Studies: A Critical Review

Jeon, H. H., Teixeira, H. S., & Tsai, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081733 · Cited by 81 · see citing works

Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice

Grimston, S. K., Watkins, M. P., Brodt, M. D., Silva, M. J., & Civitelli, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044222 · Cited by 81 · see citing works

Ciliary diffusion barrier: The gatekeeper for the primary cilium compartment

Hu, Q., & Nelson, W. J. (2011) · Cytoskeleton · doi:10.1002/cm.20514 · Cited by 79 · see citing works

Effects of cyclic hydraulic pressure on osteocytes

Liu, C., Zhao, Y., Cheung, W.-Y., Gandhi, R., Wang, L., & You, L. (2010) · Bone · doi:10.1016/j.bone.2010.02.006 · Cited by 88 · see citing works

A bioreactor test system to mimic the biological and mechanical environment of oral soft tissues and to evaluate substitutes for connective tissue grafts

Mathes, S. H., Wohlwend, L., Uebersax, L., von Mentlen, R., Thoma, D. S., Jung, R. E., Görlach, C., & Graf‐Hausner, U. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22893 · Cited by 80 · see citing works

Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium

Xie, Y., Shi, W., Zhou, J., Gao, Y., Li, S.-F., Fang, Q.-Q., Wang, M., Ma, H., Wang, J., Xian, C. J., et al. (2016) · Bone · doi:10.1016/j.bone.2016.09.008 · Cited by 80 · see citing works

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Gopalakrishnan, J., Feistel, K., Friedrich, B. M., Grapin‐Botton, A., Jurisch‐Yaksi, N., Mass, E., Mick, D. U., Müller, R., May‐Simera, H., Schermer, B., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023113891 · Cited by 79 · see citing works

Effect of in vitro stress‐deprivation and cyclic loading on the length of tendon cell cilia in situ

Gardner, K. L., ARNOCZKY, S. P., & Lavagnino, M. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21271 · Cited by 78 · see citing works

The solitary (primary) cilium–A mechanosensory toggle switch in bone and cartilage cells

Whitfield, J. F. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.001 · Cited by 78 · see citing works

The role of integrin αVβ3 in osteocyte mechanotransduction

Haugh, M. G., Vaughan, T. J., & McNamara, L. M. (2014) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2014.11.001 · Cited by 78 · see citing works

The primary cilium as a dual sensor of mechanochemical signals in chondrocytes

Muhammad, H., Rais, Y., Miosge, N., & Ornan, E. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0911-3 · Cited by 77 · see citing works

The Effects of Mechanical Loading on Mesenchymal Stem Cell Differentiation and Matrix Production

Delaine‐Smith, R. M., & Reilly, G. C. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386015-6.00039-1 · Cited by 77 · see citing works

The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts

Shi, W., Gao, Y., Wang, Y., Zhou, J., Wei, Z., Ma, X., Ma, H., Xian, C. J., Wang, J., & Chen, K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.809517 · Cited by 77 · see citing works

Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells

Vinardell, T., Rolfe, R. A., Buckley, C. T., et al. (2012) · European Cells and Materials · doi:10.22203/ecm.v023a09 · Cited by 71 · see citing works

Biophysics and Modeling of Mechanotransduction in Neurons: A Review

Nicoletti, M., Chiodo, L., & Loppini, A. (2021) · Mathematics · doi:10.3390/math9040323 · Cited by 9 · see citing works

Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone

Yu, K., Sellman, D., Bahraini, A., Hagan, M. L., Elsherbini, A. M., Vanpelt, K. T., Marshall, P. L., Hamrick, M. W., McNeil, A. K., McNeil, P. L., et al. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23665 · Cited by 43 · see citing works

In Pursuit of the Epithelial Mechanosensitivity Mechanisms

Beyder, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00804 · Cited by 19 · see citing works

Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator

Hao, J., & Delmas, P. (2011) · Nature Protocols · doi:10.1038/nprot.2011.343 · Cited by 48 · see citing works

Aging, Osteocytes, and Mechanotransduction

Hemmatian, H., Bakker, A. D., Klein‐Nulend, J., & van Lenthe, H. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0402-z · Cited by 217 · see citing works