The Primary Cilium as a Complex Signaling Center

Mutations affecting segment number and polarity in Drosophila

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

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Vertebrate Smoothened functions at the primary cilium

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Patched1 Regulates Hedgehog Signaling at the Primary Cilium

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

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PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

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The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

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<i>Chlamydomonas IFT</i> 88 and Its Mouse Homologue, Polycystic Kidney Disease Gene <i>Tg</i> 737, Are Required for Assembly of Cilia and Flagella

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Hedgehog Signaling in Development and Cancer

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Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function

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The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

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Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium

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Cilia and Hedgehog responsiveness in the mouse

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Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

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Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene

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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

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Triallelic Inheritance in Bardet-Biedl Syndrome, a Mendelian Recessive Disorder

Katsanis, N., Ansley, S. J., Badano, J. L., Eichers, E. R., Lewis, R. A., Hoskins, B. E., Scambler, P. J., Davidson, W. S., Beales, P. L., & Lupski, J. R. (2001) · Science · doi:10.1126/science.1063525 · Cited by 655 · see citing works

Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut

Essner, J. J., Amack, J. D., Nyholm, M. K., Harris, E. B., & Yost, H. J. (2005) · Development · doi:10.1242/dev.01663 · Cited by 620 · see citing works

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

Ross, A. J., May‐Simera, H., Eichers, E. R., Kai, M., Hill, J. E., Jagger, D. J., Leitch, C. C., Chapple, J. P., Munro, P., Fisher, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1644 · Cited by 595 · see citing works

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

Lin, F., Hiesberger, T., Cordes, K. R., Sinclair, A. M., Goldstein, L. S. B., Somlo, S., & Igarashi, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0836980100 · Cited by 588 · see citing works

A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans

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FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination

Tanaka, Y., Okada, Y., & Hirokawa, N. (2005) · Nature · doi:10.1038/nature03494 · Cited by 538 · see citing works

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

Liu, A., Wang, B., & Niswander, L. A. (2005) · Development · doi:10.1242/dev.01894 · Cited by 536 · see citing works

Defective planar cell polarity in polycystic kidney disease

Fischer, E. A., Legué, E., Doyen, A., Nato, F., Nicolas, J.-F., Torres, V. E., Yaniv, M., & Pontoglio, M. (2005) · Nature Genetics · doi:10.1038/ng1701 · Cited by 534 · see citing works

Cilia and Developmental Signaling

Eggenschwiler, J. T., & Anderson, K. V. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123249 · Cited by 530 · see citing works

Chapter Two Intraflagellar Transport (IFT)

Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521 · see citing works

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

Saburi, S., Hester, I., Fischer, E. A., Pontoglio, M., Eremina, V., Gessler, M., Quaggin, S., Harrison, R. V., Mount, R. J., & McNeill, H. (2008) · Nature Genetics · doi:10.1038/ng.179 · Cited by 517 · see citing works

Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms

Corbit, K. C., Shyer, A. E., Dowdle, W. E., Gaulden, J., Singla, V., & Reiter, J. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1670 · Cited by 509 · see citing works

Decoding Cilia Function

Avidor‐Reiss, T., Maer, A. M., Koundakjian, E. J., Polyanovsky, A. D., Keil, T. A., Subramaniam, S., & Zuker, C. S. (2004) · Cell · doi:10.1016/s0092-8674(04)00412-x · Cited by 505 · see citing works

Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease

Davenport, J. R., Watts, A. J., Roper, V. C., Croyle, M. J., van Groen, T., Wyss, J. M., Nagy, T. R., Kesterson, R. A., & Yoder, B. K. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.034 · Cited by 482 · see citing works

The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance

Pazour, G. J., Baker, S. A., Deane, J. A., Cole, D. G., Dickert, B. L., Rosenbaum, J. L., Witman, G. B., & Besharse, J. C. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200107108 · Cited by 478 · see citing works

Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

Berbari, N. F., Lewis, J. S., Bishop, G. A., Askwith, C. C., & Mykytyn, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711027105 · Cited by 474 · see citing works

The vertebrate primary cilium is a sensory organelle

Pazour, G. J., & Witman, G. B. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00012-1 · Cited by 466 · see citing works

Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1

Nauli, S. M., Kawanabe, Y., Kaminski, J. J., Pearce, W. J., Ingber, D. E., & Zhou, J. (2008) · Circulation · doi:10.1161/circulationaha.107.710111 · Cited by 466 · see citing works

Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

Park, T. J., Mitchell, B. J., Abitua, P. B., Kintner, C. R., & Wallingford, J. B. (2008) · Nature Genetics · doi:10.1038/ng.104 · Cited by 448 · see citing works

A Proteomic Analysis of Human Cilia

Ostrowski, L. E., Blackburn, K., Radde, K. M., Moyer, M. B., Schlatzer, D., Moseley, M. A., & Boucher, R. C. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200037-mcp200 · Cited by 441 · see citing works

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

Piontek, K., Menezes, L. F., García-González, M. Á., Huso, D. L., & Germino, G. G. (2007) · Nature Medicine · doi:10.1038/nm1675 · Cited by 424 · see citing works

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response

Gerdes, J. M., Liu, Y., Zaghloul, N. A., Leitch, C. C., Lawson, S. S., Kato, M., Beachy, P. A., Beales, P. L., DeMartino, G. N., Fisher, S., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.12 · Cited by 399 · see citing works

Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling

Park, T. J., Haigo, S. L., & Wallingford, J. B. (2006) · Nature Genetics · doi:10.1038/ng1753 · Cited by 389 · see citing works

Selective targeting of somatostatin receptor 3 to neuronal cilia

Händel, M., Schulz, S., Stanarius, A., Schreff, M., Erdtmann-Vourliotis, M., Schmidt, H., Wolf, G. L., & Höllt, V. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00354-6 · Cited by 380 · see citing works

Intraflagellar Transport

Scholey, J. M. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091318 · Cited by 378 · see citing works

Conserved function for embryonic nodal cilia

Essner, J. J., Vogan, K. J., Wagner, M. K., Tabin, C. J., Yost, H. J., & Brueckner, M. K. (2002) · Nature · doi:10.1038/418037a · Cited by 375 · see citing works

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

Welscher, P. T., Zúñiga, A., Kuijper, S. J. M., Drenth, T., Goedemans, H. J., Meijlink, F. C. P. W., & Zeller, R. (2002) · Science · doi:10.1126/science.1075620 · Cited by 375 · see citing works

Nephronophthisis

Hildebrandt, F., Attanasio, M., & Otto, E. A. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008050456 · Cited by 373 · see citing works

Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse

Kulaga, H. M., Leitch, C. C., Eichers, E. R., Badano, J. L., Lesemann, A., Hoskins, B. E., Lupski, J. R., Beales, P. L., Reed, R. R., & Katsanis, N. (2004) · Nature Genetics · doi:10.1038/ng1418 · Cited by 365 · see citing works

Polycystin-1, STAT6, and P100 Function in a Pathway that Transduces Ciliary Mechanosensation and Is Activated in Polycystic Kidney Disease

Low, S. H., Vasanth, S., Larson, C. H., Mukherjee, S., Sharma, N., Kinter, M. T., Kane, M. E., Obara, T., & Weimbs, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.005 · Cited by 364 · see citing works

Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome

Mykytyn, K., Nishimura, D. Y., Searby, C. C., Shastri, M., Yen, H.-J., Beck, J. S., Braun, T. A., Streb, L. M., Cornier, A. S., Cox, G. F., et al. (2002) · Nature Genetics · doi:10.1038/ng935 · Cited by 360 · see citing works

Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors

Berbari, N. F., Johnson, A. D., Lewis, J. S., Askwith, C. C., & Mykytyn, K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0942 · Cited by 352 · see citing works

An incredible decade for the primary cilium: a look at a once-forgotten organelle

Davenport, J. R., & Yoder, B. K. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00118.2005 · Cited by 350 · see citing works

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

Breunig, J. J., Sarkisian, M. R., Arellano, J. I., Morozov, Y. M., Ayoub, A. E., Sojitra, S., Wang, B., Flavell, R. A., Rakic, P., & Town, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804558105 · Cited by 344 · see citing works

Ciliary proteins link basal body polarization to planar cell polarity regulation

Jones, C., Roper, V. C., Foucher, I., Qian, D., Banizs, B., Petit, C., Yoder, B. K., & Chen, P. (2007) · Nature Genetics · doi:10.1038/ng.2007.54 · Cited by 337 · see citing works

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

Tran, P. V., Haycraft, C. J., Besschetnova, T. Y., Turbé-Doan, A., Stottmann, R. W., Herron, B. J., Chesebro, A. L., Qiu, H., Scherz, P., Shah, J. V., et al. (2008) · Nature Genetics · doi:10.1038/ng.105 · Cited by 337 · see citing works

Bardet–Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly

Mykytyn, K., Mullins, R. F., Andrews, M., Chiang, A. P.-F., Swiderski, R. E., Yang, B., Braun, T. A., Casavant, T. L., Stone, E. M., & Sheffield, V. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402354101 · Cited by 336 · see citing works

The RFX-Type Transcription Factor DAF-19 Regulates Sensory Neuron Cilium Formation in C. elegans

Swoboda, P., Adler, H. T., & Thomas, J. H. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80436-0 · Cited by 336 · see citing works

Characterization of PKD Protein-Positive Exosome-Like Vesicles

Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I., Masyuk, T. V., Tammachote, R., Huang, B. Q., Leontovich, A. A., Beito, T. G., Madden, B. J., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008060564 · Cited by 329 · see citing works

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

Patel, V., Li, L., Cobo-Stark, P., Shao, X., Somlo, S., Lin, F., & Igarashi, P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn045 · Cited by 323 · see citing works

Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain

Bishop, G. A., Berbari, N. F., Lewis, J., & Mykytyn, K. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21510 · Cited by 317 · see citing works

The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway

Barr, M. M., DeModena, J. A., Braun, D., Nguyen, C. Q., Hall, D. H., & Sternberg, P. W. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00423-7 · Cited by 317 · see citing works

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Yang, Y., Drossopoulou, G. I., Chuang, P., Duprez, D., Martı́, E., Bumcrot, D. A., Vargesson, N., Clarke, J. D. W., Niswander, L. A., McMahon, A. P., et al. (1997) · Development · doi:10.1242/dev.124.21.4393 · Cited by 315 · see citing works

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

Seo, S., Guo, D., Bugge, K., Morgan, D. A., Rahmouni, K., & Sheffield, V. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp031 · Cited by 315 · see citing works

The renal cell primary cilium functions as a flow sensor

Prætorius, H. A., & Spring, K. R. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200309000-00006 · Cited by 280 · see citing works

Functional Genomics of the Cilium, a Sensory Organelle

Blacque, O. E., Perens, E. A., Boroevich, K. A., Inglis, P. N., Li, C., Warner, A., Khattra, J. S., Holt, R. A., Ou, G., Mah, A. K., et al. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.059 · Cited by 270 · see citing works

Genetic Interaction of BBS1 Mutations with Alleles at Other BBS Loci Can Result in Non-Mendelian Bardet-Biedl Syndrome

Beales, P. L., Badano, J. L., Ross, A. J., Ansley, S. J., Hoskins, B. E., Kirsten, B., Mein, C. A., Froguel, P., Scambler, P. J., Lewis, R. A., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375178 · Cited by 264 · see citing works

A knockin mouse model of the Bardet–Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity

Davis, R. E., Swiderski, R. E., Rahmouni, K., Nishimura, D. Y., Mullins, R. F., Agassandian, K., Philp, A. R., Searby, C. C., Andrews, M., Thompson, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708571104 · Cited by 259 · see citing works

Localization of 5-HT6 receptors at the plasma membrane of neuronal cilia in the rat brain

Brailov, I., Bancila, M., Brisorgueil, M.-J., Miquel, M.-C., Hamon, M., & Vergé, D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02519-1 · Cited by 245 · see citing works

Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder.

Katsanis, N., Ansley, S., Badano, J., Eichers, E., Ra, L., Hoskins, B., Scambler, P. J., Davidson, W. S., Beales, P. L., & Lupski (2002) · UCL Discovery (University College London) · Cited by 240 · see citing works

Chapter 13 Ciliary Dysfunction in Developmental Abnormalities and Diseases

Sharma, N., Berbari, N. F., & Yoder, B. K. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00813-2 · Cited by 234 · see citing works

Turnover of rod photoreceptor outer segments. II. Membrane addition and loss in relationship to light

Besharse, J. C., Hollyfield, J. G., & Rayborn, M. E. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.75.2.507 · Cited by 224 · see citing works

Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus

Badano, J. L. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg188 · Cited by 211 · see citing works

Piecing together a ciliome

Inglis, P. N., Boroevich, K. A., & LEROUX, M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.07.006 · Cited by 206 · see citing works

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

Yu, S., Hackmann, K., Gao, J., He, X., Piontek, K., García-González, M. Á., Menezes, L. F., Xu, H., Germino, G. G., Zuo, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708217104 · Cited by 200 · see citing works

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts

Ocbina, P. J. R., & Anderson, K. V. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21551 · Cited by 192 · see citing works

Localization of Extracellular Matrix Receptors on the Chondrocyte Primary Cilium

McGlashan, S. R., Jensen, C. G., & Poole, C. A. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6866.2006 · Cited by 191 · see citing works

Genetics of Sensory Mechanotransduction

Ernstrom, G. G., & Chalfie, M. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.061802.101708 · Cited by 191 · see citing works

Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors

Insinna, C., & Besharse, J. C. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21554 · Cited by 190 · see citing works

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

Incardona, J. P., Gruenberg, J. E., & Roelink, H. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00895-3 · Cited by 183 · see citing works

orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

Cano, D. A., Murcia, N. S., Pazour, G. J., & Hebrok, M. (2004) · Development · doi:10.1242/dev.01189 · Cited by 183 · see citing works

Intraflagellar Transport and Cilia-Dependent Renal Disease

Pazour, G. J. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141055.57643.e0 · Cited by 178 · see citing works

Development of the post-natal growth plate requires intraflagellar transport proteins

Song, B., Haycraft, C. J., Seo, H., Yoder, B. K., & Serra, R. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.003 · Cited by 171 · see citing works

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

Pan, Y., Wang, C., & Wang, B. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.009 · Cited by 154 · see citing works

Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery

Kiprilov, E. N., Awan, A., Desprat, R., Velho, M., Clement, C. A., Byskov, A. G., Andersen, C. Y., Satir, P., Bouhassira, E. E., Christensen, S. T., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200706028 · Cited by 153 · see citing works

Chapter 5 Targeting Proteins to the Ciliary Membrane

Pazour, G. J., & Bloodgood, R. A. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00805-3 · Cited by 145 · see citing works

Gli2 Is Targeted for Ubiquitination and Degradation by β-TrCP Ubiquitin Ligase

Saleem, M., Thiyagarajan, S., Elcheva, I. A., Saleem, M., Dlugosz, A. A., Mukhtar, H., & Spiegelman, V. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513203200 · Cited by 139 · see citing works

Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya

Oishi, I., Kawakami, Y., Raya, Á., Callol-Massot, C., & Belmonte, J. C. I. (2006) · Nature Genetics · doi:10.1038/ng1892 · Cited by 126 · see citing works

Basal bodies platforms for building cilia.

Marshall, W. F. (2008) · PubMed · doi:10.1016/s0070-2153(08)00801-6 · Cited by 125 · see citing works

Hippocampal neurons possess primary cilia in culture

Berbari, N. F., Bishop, G. A., Askwith, C. C., Lewis, J. S., & Mykytyn, K. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21209 · Cited by 111 · see citing works

Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet–Biedl syndrome

Abd‐El‐Barr, M. M., Sykoudis, K., Andrabi, S., Eichers, E. R., Pennesi, M. E., Tan, P. L., Wilson, J. H., Katsanis, N., Lupski, J. R., & Wu, S. M.-S. (2007) · Vision Research · doi:10.1016/j.visres.2007.09.016 · Cited by 109 · see citing works

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region

Shiba, D., Yamaoka, Y., Hagiwara, H., Takamatsu, T., Hamada, H., & Yokoyama, T. (2008) · Journal of Cell Science · doi:10.1242/jcs.037408 · Cited by 108 · see citing works

An IFT-A Protein Is Required to Delimit Functionally Distinct Zones in Mechanosensory Cilia

Lee, E., Sivan‐Loukianova, E., Eberl, D. F., & Kernan, M. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.11.020 · Cited by 106 · see citing works

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

Wang, C., Rüther, U., & Wang, B. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.029 · Cited by 106 · see citing works

Turnover of mouse photoreceptor outer segments in constant light and darkness.

Besharse, J. C., & Hollyfield, J. G. (1979) · PubMed · Cited by 105 · see citing works

Identification of ciliary and ciliopathy genes in Caenorhabditis elegansthrough comparative genomics

Chen, N., Mah, A. K., Blacque, O. E., Chu, J. S.-C., Phgora, K., Bakhoum, M. W., Newbury, C. R. H., Khattra, J. S., Chan, S. Y., Go, A., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-12-r126 · Cited by 96 · see citing works

Chapter Eight Primary Cilia in Planar Cell Polarity Regulation of the Inner Ear

Jones, C., & Chen, P. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00808-9 · Cited by 88 · see citing works

β1-Integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+signaling

Prætorius, H. A., Prætorius, J., Nielsen, S., Frøkiær, J., & Spring, K. R. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00096.2004 · Cited by 88 · see citing works

Non-Random Distribution and Sensory Functions of Primary Cilia in Vascular Smooth Muscle Cells

Lu, C. J., Du, H., Wu, J., Jansen, D. A., Jordan, K. L., Xu, N., Sieck, G. C., & Qian, Q. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000132462 · Cited by 79 · see citing works

Renal Cysts of inv/inv Mice Resemble Early Infantile Nephronophthisis

Phillips, C. L., Miller, K. J., Filson, A. J., Nürnberger, J., Clendenon, J. L., Cook, G. W., Dunn, K. W., Overbeek, P. A., Gattone, V. H., & Bacallao, R. L. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000131520.07008.b3 · Cited by 77 · see citing works

Chapter 12 Olfactory Cilia: Our Direct Neuronal Connection to the External World

McEwen, D. P., Jenkins, P. M., & Martens, J. R. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00812-0 · Cited by 76 · see citing works

Loss of Bardet–Biedl syndrome proteins causes defects in peripheral sensory innervation and function

Tan, P. L., Barr, T. P., Inglis, P. N., Mitsuma, N., Huang, S. M., García-González, M. Á., Bradley, B. A., Coforio, S., Albrecht, P. J., Watnick, T. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706618104 · Cited by 74 · see citing works

Chapter 7 Ciliary Function and Wnt Signal Modulation

Gerdes, J. M., & Katsanis, N. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00807-7 · Cited by 73 · see citing works

Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells

Raychowdhury, M. K., Ramos, A. J., Zhang, P., McLaughin, M., Dai, X.-Q., Chen, X.-Z., Montalbetti, N., del Rocío Cantero, M., Ausiello, D. A., & Cantiello, H. F. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90509.2008 · Cited by 73 · see citing works

Turnover of rod photoreceptor outer segments. I. Membrane addition and loss in relationship to temperature.

Hollyfield, J. G., Besharse, J. C., & Rayborn, M. E. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.75.2.490 · Cited by 72 · see citing works

Mutation analysis of the MKKS gene in McKusick-Kaufman syndrome and selected Bardet-Biedl syndrome patients

Slavotinek, A. M., Searby, C. C., Al‐Gazali, L., Hennekam, R. C. M., Schrander-Stumpel, C. T. R. M., Orcana-Losa, M., Pardo-Reoyo, S., Cantani, A., Kumar, D., Capellini, Q., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0733-3 · Cited by 68 · see citing works

Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines

Nielsen, S., Møllgård, K., Clement, C. A., Veland, I. R., Awan, A., Yoder, B. K., Novak, I., & Christensen, S. T. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21610 · Cited by 64 · see citing works

Developmental changes in frequency of the ciliary somatostatin receptor 3 protein

Stanić, D., Malmgren, H., He, H., Scott, L., Aperia, A. C., & Hökfelt, T. G. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.024 · Cited by 55 · see citing works

Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene

Schrick, J. J., Onuchic², L. F., Reeders, S. T., Korenberg, J. R., Chen, X.-N., Moyer, J. H., Wilkinson, J. E., & Woychik, R. P. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.4.559 · Cited by 45 · see citing works

Comparative Genomics: Prediction of the Ciliary and Basal Body Proteome

Pazour, G. J. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.017 · Cited by 45 · see citing works

Novel tools to unravel molecular mechanisms in cilia-related disorders

Fliegauf, M., & Omran, H. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.002 · Cited by 26 · see citing works

No evidence for triallelic inheritance ofMKKS/BBS loci in Amish Mckusick-Kaufman syndrome

Nakane, T., & Biesecker, L. G. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30593 · Cited by 19 · see citing works

Maladies kystiques du foie

Housset, C. (2005) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(05)86361-4 · Cited by 16 · see citing works

Maladies kystiques du foie. Génétique et biologie cellulaire.

Housset, C. (2005) · Gastroentérologie Clinique et Biologique · Cited by 12 · see citing works

Non-syndromic retinitis pigmentosa

Verbakel, S. K., van Huet, R. A. C., Boon, C. J. F., den Hollander, A. I., Collin, R. W. J., Klaver, C. C. W., Hoyng, C. B., Roepman, R., & Klevering, B. J. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.03.005 · Cited by 973 · see citing works

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

Chávez, M., Ena, S., Van Sande, J., de Kerchove d’Exaerde, A., Schurmans, S., & Schiffmann, S. N. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.016 · Cited by 276 · see citing works

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

Lancaster, M. A., Schroth, J., & Gleeson, J. G. (2011) · Nature Cell Biology · doi:10.1038/ncb2259 · Cited by 267 · see citing works

Physiology of Cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120019 · Cited by 240 · see citing works

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

Domire, J. S., Green, J. A., Lee, K. G., Johnson, A. D., Askwith, C. C., & Mykytyn, K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0603-4 · Cited by 217 · see citing works

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

Choi, Y.-H., Suzuki, A., Hajarnis, S., Ma, Z., Chapin, H. C., Caplan, M. J., Pontoglio, M., Somlo, S., & Igarashi, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016214108 · Cited by 139 · see citing works

Inner lumen proteins stabilize doublet microtubules in cilia and flagella

Owa, M., Uchihashi, T., Yanagisawa, H.-A., Yamano, T., Iguchi, H., Fukuzawa, H., Wakabayashi, K.-I., Ando, T., & Kikkawa, M. (2019) · Nature Communications · doi:10.1038/s41467-019-09051-x · Cited by 140 · see citing works

Polycystin-1: A master regulator of intersecting cystic pathways

Fedeles, S. V., Gallagher, A.-R., & Somlo, S. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.004 · Cited by 130 · see citing works

Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins

Behal, R. H., Miller, M. S., Qin, H., Lucker, B. F., Jones, A., & Cole, D. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287102 · Cited by 119 · see citing works

Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

Megraw, T. L., Sharkey, J. T., & Nowakowski, R. S. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.04.007 · Cited by 124 · see citing works

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

Berbari, N. F., Pasek, R. C., Malarkey, E. B., Yazdi, S. M. Z., McNair, A. D., Lewis, W. R., Nagy, T. R., Kesterson, R. A., & Yoder, B. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210192110 · Cited by 98 · see citing works

Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium

Blitzer, A. L., Panagis, L., Gusella, G. L., Danias, J., Mlodzik, M., & Iomini, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016702108 · Cited by 83 · see citing works

Hippocampal and Cortical Primary Cilia Are Required for Aversive Memory in Mice

Berbari, N. F., Malarkey, E. B., Yazdi, S. M. Z. R., McNair, A. D., Kippe, J. M., Croyle, M. J., Kraft, T. W., & Yoder, B. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106576 · Cited by 69 · see citing works

Kinesin motors and primary cilia

Verhey, K. J., Dishinger, J., & Kee, H. L. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391120 · Cited by 79 · see citing works

Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization

Green, J. A., Schmid, C. L., Bley, E., Monsma, P. C., Brown, A., Bohn, L. M., & Mykytyn, K. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00765-15 · Cited by 67 · see citing works

Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure

Vorobyeva, A. G., & Saunders, A. J. (2018) · Cilia · doi:10.1186/s13630-018-0059-y · Cited by 67 · see citing works

Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway

Grisanti, L., Revenkova, E., Gordon, R. E., & Iomini, C. (2016) · Development · doi:10.1242/dev.132704 · Cited by 71 · see citing works

GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis

Zhang, B., Zhang, T., Wang, G., Wang, G., Chi, W., Jiang, Q., & Zhang, C. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002129 · Cited by 60 · see citing works

Physiology of Cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00495.x · Cited by 52 · see citing works

Primary Cilia as a Signaling Platform for Control of Energy Metabolism

Song, D. K., Choi, J. H., & Kim, M.-S. (2018) · Diabetes &amp; Metabolism Journal · doi:10.4093/dmj.2018.42.2.117 · Cited by 42 · see citing works

The Ciliary Protein Ftm Is Required for Ventricular Wall and Septal Development

Gerhardt, C., Lier, J. M., Kuschel, S., & Rüther, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057545 · Cited by 42 · see citing works

Investigating Embryonic Expression Patterns and Evolution of AHI1 and CEP290 Genes, Implicated in Joubert Syndrome

Cheng, Y.-Z., Eley, L., Hynes, A.-M., Overman, L. M., Simms, R. J., Barker, A., Dawe, H. R., Lindsay, S., & Sayer, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044975 · Cited by 16 · see citing works

Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids

Ning, K., Luo, Z., Kowal, T. J., Tran, M., Majumder, R., Jarin, T. M., Wu, A. Y., Goldberg, J. L., & Sun, Y. (2023) · Stem Cells International · doi:10.1155/2023/6494486 · Cited by 10 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

The role of cilia in the pathogenesis of cystic kidney disease

Dell, K. M. (2015) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000187 · Cited by 34 · see citing works

Analysis of primary cilia in renal tissue and cells

Silva, L. M., Wang, W., Allard, B. A., Pottorf, T. S., Jacobs, D. T., & Tran, P. V. (2019) · Methods in cell biology · doi:10.1016/bs.mcb.2019.04.008 · Cited by 13 · see citing works

Isolation of Mammalian Primary Cilia

Ishikawa, H., & Marshall, W. F. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-397944-5.00015-8 · Cited by 13 · see citing works