The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Rapid Atrophy of the Lumbar Multifidus Follows Experimental Disc or Nerve Root Injury
Abstract
In Brief Study Design. Experimental study of muscle changes after lumbar spinal injury. Objectives. To investigate effects of intervertebral disc and nerve root lesions on cross-sectional area, histology and chemistry of porcine lumbar multifidus. Summary of Background Data. The multifidus cross-sectional area is reduced in acute and chronic low back pain. Although chronic changes are widespread, acute changes at 1 segment are identified within days of injury. It is uncertain whether changes precede or follow injury, or what is the mechanism. Methods. The multifidus cross-sectional area was measured in 21 pigs from L1 to S1 with ultrasound before and 3 or 6 days after lesions: incision into L3–L4 disc, medial branch transection of the L3 dorsal ramus, and a sham procedure. Samples from L3 to L5 were studied histologically and chemically. Results. The multifidus cross-sectional area was reduced at L4 ipsilateral to disc lesion but at L4–L6 after nerve lesion. There was no change after sham or on the opposite side. Water and lactate were reduced bilaterally after disc lesion and ipsilateral to nerve lesion. Histology revealed enlargement of adipocytes and clustering of myofibers at multiple levels after disc and nerve lesions. Conclusions. These data resolve the controversy that the multifidus cross-sectional area reduces rapidly after lumbar injury. Changes after disc lesion affect 1 level with a different distribution to denervation. Such changes may be due to disuse following reflex inhibitory mechanisms. The effects of injury to the L3–L4 intervertebral disc and medial branch of the L3 dorsal ramus on cross-sectional area, histology and chemistry of lumbar multifidus were evaluated in pigs. The multifidus cross-sectional area was reduced at 1 level after disc lesion but over 3 levels after nerve root transection. Consistent with clinical human data, these results confirm that changes in muscle size occur rapidly after injury.
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Citations
Cites
Multifidus Muscle Recovery Is Not Automatic After Resolution of Acute, First-Episode Low Back Pain
Hides, J. A., Richardson, C. A., & Jull, G. A. (1996) · Spine · doi:10.1097/00007632-199612010-00011 · Cited by 1,115
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Long-Term Effects of Specific Stabilizing Exercises for First-Episode Low Back Pain
Hides, J. A., Jull, G. A., & Richardson, C. A. (2001) · Spine · doi:10.1097/00007632-200106010-00004 · Cited by 843
CT imaging of trunk muscles in chronic low back pain patients and healthy control subjects
Danneels, L. A., Vanderstraeten, G. G., Cambier, D. C., Witvrouw, E. E., De Cuyper, H. J., & Danneels, L. (2000) · European Spine Journal · doi:10.1007/s005860000190 · Cited by 653
Stability Increase of the Lumbar Spine With Different Muscle Groups: A Biomechanical In Vitro Study
Wilke, H.-J., Wolf, S., Claes, L. E., Arand, M., & Wiesend, A. (1995) · Spine · doi:10.1097/00007632-199501150-00011 · Cited by 557
Physiology of a Microgravity Environment Invited Review: Microgravity and skeletal muscle
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The use of a quadruped as an in vivo model for the study of the spine – biomechanical considerations
Smit, T. H. (2002) · European Spine Journal · doi:10.1007/s005860100346 · Cited by 486
Functional and structural adaptations of skeletal muscle to microgravity
Fitts, R. H., Riley, D. R., & Widrick, J. J. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.18.3201 · Cited by 477
Are Sheep Spines a Valid Biomechanical Model for Human Spines?
Wilke, H.-J., Kettler, A., & Claes, L. E. (1997) · Spine · doi:10.1097/00007632-199710150-00009 · Cited by 455
The nerve supply to the human lumbar intervertebral discs.
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Cited by
MacDonald, D., Moseley, L. G., & Hodges, P. W. (2009) · Pain · doi:10.1016/j.pain.2008.12.002 · Cited by 368
Self-citationHodges, P. W., & Smeets, R. J. (2015) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000098 · Cited by 351
Self-citationHides, J., Stanton, W., Mcmahon, S., Sims, K., & Richardson, C. (2008) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2008.2658 · Cited by 334
Koppenhaver, S. L., Hebert, J. J., Fritz, J. M., Parent, E. C., Teyhen, D. S., & Magel, J. S. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.06.022 · Cited by 300
Crawford, R. J., Filli, L., Elliott, J. M., Nanz, D., Fischer, M. A., Marcon, M., & Ulbrich, E. J. (2016) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4596 · Cited by 257
Metadata
- Authors
- Hodges, P., Holm, A. K., Hansson, T., & Holm, S.
- Venue
- Spine
- Published
- 2006-12
- Volume
- 31
- Issue
- 25
- Pages
- 2926-2933
- ISSN
- 0362-2436 (ISSN-L)
- OpenAlex
- W2034992242
- Cited by
- 383
- References
- 53
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hodges, P., Holm, A. K., Hansson, T., & Holm, S. (2006). Rapid Atrophy of the Lumbar Multifidus Follows Experimental Disc or Nerve Root Injury. Spine. https://doi.org/10.1097/01.brs.0000248453.51165.0b
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