The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*
Abstract
OBJECTIVE: Enteral glutamine supplements have been shown to reduce infectious morbidity in trauma patients, but their effect on burn patients is not known. The objective of this study was to measure the impact of enteral glutamine supplementation on infectious morbidity, length of care, and the immune system in burn patients. DESIGN: Double-blinded, randomized clinical trial. SETTING: Burn center. PATIENTS: Forty-five adults with severe burns. INTERVENTIONS: Patients were randomized to receive either glutamine or an isonitrogenous control mixture until complete healing occurred. Length of care, incidence of positive blood culture, and mortality were recorded. Phagocytosis by circulating polymorphonuclear cells was measured every 3 days. MEASUREMENTS AND MAIN RESULTS: Patient characteristics were similar in both groups. Four patients were excluded from the analysis, because three of them died within 72 hrs and the fourth could not receive enteral nutrition and amino acid supplements for the first 10 days. Of the remaining 41 patients, length of care in the survivors was not different between groups (0.9 vs. 1.0 days/percent total body surface area for glutamine vs. control, respectively), positive blood culture was three times more frequent in control than in glutamine treatment (4.3 vs. 1.2 days/patient, p <.05), and Pseudomonas aeruginosa was detected in six patients on control and zero on glutamine (p <.05). Phagocytosis by polymorphonuclear cells was not different between groups. Mortality rate was significantly lower in glutamine than in control: intention to treat, two vs. 12 (p <.05); per protocol analysis, zero vs. eight (p <.01). CONCLUSIONS: Enteral glutamine supplementation in adult burn patients reduces blood infection by a factor of three, prevents bacteremia with P. aeruginosa, and may decrease mortality rate. It has no effect on level of consciousness and does not appear to influence phagocytosis by circulating polymorphonuclear cells.
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Citations
Cites
Glutamine supplementation in serious illness: A systematic review of the evidence*
Novak, F., Heyland, D. K., Avenell, A., Drover, J. W., & Su, X. (2002) · Critical Care Medicine · doi:10.1097/00003246-200209000-00011 · Cited by 717
Houdijk, A. P., Rijnsburger, E. R., Jansen, J., Wesdorp, R. I., Weiss, J. K., McCamish, M. A., Teerlink, T., Meuwissen, S. G., Haarman, H. J. T. M., Thijs, L. G., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02007-8 · Cited by 620 · cited 2×
“(6) in trauma patients given enteral G.”
BackgroundIdentification of patients with acute lung injury. Predictors of mortality.
Doyle, R. L., Szaflarski, N., Modin, G. W., Wiener-Kronish, J. P., & Matthay, M. A. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.6.8520742 · Cited by 498
Does glutamine contribute to immunosuppression after major burns?
Parry-Billings, M., Calder, P. C., Newsholme, E. A., & Evans, J. (1990) · The Lancet · doi:10.1016/0140-6736(90)92083-t · Cited by 353
Wischmeyer, P. E., Lynch, J., Liedel, J., Wolfson, R., Riehm, J., Gottlieb, L., & Kahana, M. (2001) · Critical Care Medicine · doi:10.1097/00003246-200111000-00006 · Cited by 320
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Enteral glutamine supplementation for very low birth weight infants decreases morbidity
Neu, J., Roig, J. C., Meetze, W. H., Veerman, M., Carter, C., Millsaps, M., Bowling, D., Dallas, M. J., Sleasman, J., Knight, T., et al. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70095-7 · Cited by 253
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Plasma amino acids determined by liquid chromatography within 17 minutes
Terrlink, T., van Leeuwen, P. A., & Houdijk, A. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.245 · Cited by 197
Ogle, C. K., Ogle, J. D., Mao, J., Simon, J., Noel, J. G., Li, B., & Alexander, J. W. (1994) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607194018002128 · Cited by 175
Cited by
McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
McClave, S. A., Martindale, R. G., Vanek, V. W., McCarthy, M., Roberts, P., Taylor, B., Ochoa, J. B., Napolitano, L., Cresci, G., the A.S.P.E.N. Board of Directors, et al. (2009) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109335234 · Cited by 1,873
Taylor, B. E., McClave, S. A., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001525 · Cited by 1,476
ESPEN guidelines on enteral nutrition: intensive care
Kreymann, K. G., Berger, M. M., Deutz, N. E. P., Hiesmayr, M., Jolliet, P., Kazandjiev, G., Nitenberg, G., van den Berghe, G., Wernerman, J., Ebner, C., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.01.021 · Cited by 1,366
Metadata
- Authors
- Garrel, D., Patenaude, J., Nedelec, B., Samson, L., Dorais, J., Champoux, J., D’Elia, M., & Bernier, J.
- Venue
- Critical Care Medicine
- Published
- 2003-10
- Volume
- 31
- Issue
- 10
- Pages
- 2444-2449
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2259222336
- Cited by
- 293
- References
- 21
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garrel, D., Patenaude, J., Nedelec, B., Samson, L., Dorais, J., Champoux, J., D’Elia, M., & Bernier, J. (2003). Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*. Critical Care Medicine. https://doi.org/10.1097/01.ccm.0000084848.63691.1e
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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