Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients*
Abstract
OBJECTIVE: To determine whether haloperidol use is associated with lower mortality in mechanically ventilated patients. DESIGN: Retrospective cohort analysis. SETTING: A large tertiary care academic medical center. PATIENTS: A total of 989 patients mechanically ventilated for >48 hrs. MEASUREMENTS AND MAIN RESULTS: We compared differences in hospital mortality between patients who received haloperidol within 2 days of initiation of mechanical ventilation and those who never received haloperidol. Despite similar baseline characteristics, patients treated with haloperidol had significantly lower hospital mortality compared with those who never received haloperidol (20.5% vs. 36.1%; p = .004). The lower associated mortality persisted after adjusting for age, comorbidity, severity of illness, degree of organ dysfunction, admitting diagnosis, and other potential confounders. CONCLUSIONS: Haloperidol was associated with significantly lower hospital mortality. These findings could have enormous implications for critically ill patients. Because of their observational nature and the potential risks associated with haloperidol use, they require confirmation in a randomized, controlled trial before being applied to routine patient care.
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In a retrospective cohort study of mechanically ventilated patients, haloperidol use was associated with lower hospital mortality, at least in part because of reduced use of sedatives and analgesics.
“In a retrospective cohort study focusing on mechanically ventilated patients [32], haloperidol use was associated with lower hospital mortality, at least in part because of a reduced use of sedatives and analgesics.”
From Nicotine withdrawal and agitation in ventilated critically ill patients (2010) · cites this paper as [32]
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- Authors
- Milbrandt, E. B., Kersten, A., Kong, L., Weissfeld, L. A., Clermont, G., Fink, M. P., & Angus, D. C.
- Affiliations
- University of Pittsburgh (US)
- Pennsylvania State University (US)
- Venue
- Critical Care Medicine
- Published
- 2005-01
- Volume
- 33
- Issue
- 1
- Pages
- 226-229
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2113801876
- Cited by
- 140
- References
- 17
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 12 · 2012: 6
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- haloperidol, mechanical ventilation, in-hospital mortality, critically ill patients, antipsychotic drugs, organ dysfunction
- MeSH terms
- Adult, Aged, Critical Care, Delirium, Female, Haloperidol, Humans, Immunologic Factors, Male, Middle Aged, Psychomotor Agitation, Respiration, Artificial, Retrospective Studies, Antipsychotic Agents, Cohort Studies, Survival Rate, Procedural Sedation, Critical Illness, Hospital Mortality, Systemic Inflammatory Response Syndrome
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