Clinical review: Agitation and delirium in the critically ill – significance and management

Chevrolet, Jean-Claude; Jolliet, Philippe

doi:10.1186/cc5787

Cited by 70Intensive Care Unit Cognitive DisordersTraumatic Brain Injury ResearchAlcoholism and Thiamine Deficiency

Clinical review: Agitation and delirium in the critically ill – significance and management

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Chevrolet, Jean-Claude, Jolliet, Philippe·2007·Critical Care

DOI 10.1186/cc5787PMC PMC2206395

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Abstract

Agitation is a psychomotor disturbance characterized by a marked increase in motor and psychological activity in a patient. It occurs very frequently in the intensive care setting. It may be isolated, or accompanied by other mental disorders, such as severe anxiety and delirium. Frequently, agitation is a sign of brain dysfunction and, as such, may have adverse consequences, for at least two reasons. First, agitation can interfere with the patient's care and second, there is evidence demonstrating that the prognosis of agitated (and delirious) patients is worse than that of non-agitated (non-delirious) patients. These conditions are often under-diagnosed in the intensive care unit (ICU). Consequently, a systematic evaluation of this problem in ICU patients should be conducted. Excellent tools are presently available for this purpose. Treatment, including prevention, must be undertaken without delay, and the ICU physician should follow logical, strict and systematic rules when applying therapy.

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Delirium and agitation occur frequently in critically ill patients, with reported frequencies of 15% to 80%.
“Behavioral disorders such as delirium and agitation in the critically ill occur with a high frequency, ranging from 15% to 80% of patients, and have been associated with increased morbidity and risk of mortality [7-13].”
From Nicotine withdrawal and agitation in ventilated critically ill patients (2010) · cites this paper as [7]
Delirium and agitation in critically ill patients are associated with increased morbidity and risk of mortality.
“Behavioral disorders such as delirium and agitation in the critically ill occur with a high frequency, ranging from 15% to 80% of patients, and have been associated with increased morbidity and risk of mortality [7-13].”
From Nicotine withdrawal and agitation in ventilated critically ill patients (2010) · cites this paper as [7]

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Authors: Chevrolet, J.-C., & Jolliet, P.
Corresponding author: Chevrolet, Jean-Claude
Venue: Critical Care
Publisher: Springer Science and Business Media LLC
Published: 2007
Volume: 11
Issue: 3
Pages: 214
ISSN: 1364-8535 (ISSN-L)
DOI: 10.1186/cc5787
PMC: PMC2206395
OpenAlex: W1977653448
Cited by: 70
References: 59
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 3 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 2
FWCI: 0.62
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Critical Care (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
Keywords: agitation, delirium, critically ill patients, intensive care unit, brain dysfunction, prognosis, underdiagnosis, agitation management, delirium prevention, psychomotor disorders
MeSH terms: Critical Care, Delirium, Humans, Psychomotor Agitation, Critical Illness

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Clinical review: Agitation and delirium in the critically ill – significance and management

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