The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.
Glucocorticoid therapy in neurologic critical care
Abstract
BACKGROUND: The pivotal role of inflammation and edema across the spectrum of central nervous system injury has driven extensive investigation into the therapeutic potential of glucocorticoids. OBJECTIVE: To review the experimental and clinical data relating to the efficacy and adverse effects of glucocorticoids in conditions encountered in critical neurologic and neurosurgical illness. DATA SOURCE: Search of MEDLINE and Cochrane databases, manual review of article bibliographies. DATA SYNTHESIS AND CONCLUSIONS: The efficacy of glucocorticoids is well established in ameliorating edema associated with brain tumors and in improving outcome in subsets of patients with bacterial meningitis. Despite frequently encouraging experimental results, clinical trials of glucocorticoids in ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury have not shown a definite therapeutic effect. The evidence supporting glucocorticoid therapy for spinal cord injury is controversial; however methylprednisolone continues to be widely employed in this setting.
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“While there is widespread use of GCs in clinical neurology to control CNS inflammation in general and poststroke edema in particular, such interventions are often ineffective and can even worsen clinical outcome (Gomes et al., 2005).”
From The Stressed CNS: When Glucocorticoids Aggravate Inflammation (2009) · cites this paper as Gomes et al., 2005
Citations
Cites
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Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,075
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de Gans, J., & van de Beek, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021334 · Cited by 1,200
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Strbian, D. (2008) · Työväentutkimus Vuosikirja
Rapôso, C., & Schwartz, M. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch11
Drug Delivery in the Context of Stroke and Brain Trauma
Keep, R. F., Xiang, J., Zhou, N., & Andjelkovic, A. V. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_23
Chen, J., & Li, H. (2007) · 南京医科大学学报：英文版 · doi:10.1016/s1007-4376(07)60066-5
Kabalak, A. A., LEBLEB?C?, F., ATASOY, S., EFETÜRK, E., & GÖ?Ü?, N. (2007) · DergiPark (Istanbul University)
이훈상, 이윤진, 김영미, Min, Y. G., 김경민, & 남상욱 (2016) · Annals of Child Neurology · doi:10.26815/jkcns.2016.24.4.266
Иванович, Ш. М., Andreev, S. A., Малышева, Т. А., & Shevchuk, V. A. (2009) · Ukrainian Neurosurgical Journal · doi:10.25305/unj.108808
Perihemorrhagic edema in non-traumatic intracerebral hematomas
Dzenis, Y. L., & Olmanis, A. Y. (2018) · Ukrainian Neurosurgical Journal · doi:10.25305/unj.117778
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The Blood-Brain Barrier in Stroke and Trauma and How to Enhance Drug Delivery
Keep, R. F., Xiang, J., Zhou, N., & Andjelkovic, A. V. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_23
Tandon, M. S., Sharma, A., Mittal, R., & Bhandari, N. (2024) · Springer eBooks · doi:10.1007/978-981-99-8059-8_24
Meningoencefaliti infettive e suppurazioni intracraniche dell’adulto
Besnard, A., Abdennour, L., Korinek, A. M., Mathon, B., Shotar, E., Doirado, M., Tabillon, C., Jacquens, A., Bleibtreu, A., & Degos, V. (2025) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(24)49998-2
Meningoencefalitis infecciosa y supuración intracraneal en adultos
Besnard, A., Abdennour, L., Korinek, A. M., Mathon, B., Shotar, E., Doirado, M., Tabillon, C., Jacquens, A., Bleibtreu, A., & Degos, V. (2025) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(24)49899-x
Bruder, N., & Velly, L. J. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780198864714.003.0015
Sean Sanders DVM, P. (2025) · Wiley eBooks · doi:10.1002/9781394245642.ch7
Kim, M., Chan, H. H. N., Fisher, B. M., Bangalore, N., Shamah, M., Shimeall, S., Mandava, N., Hogue, O., Machado, A. G., & Baker, K. B. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115779
Metadata
- Authors
- Gomes, J. A., Stevens, R. D., Lewin, J. J., Mirski, M. A., & Bhardwaj, A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Critical Care Medicine
- Published
- 2005-06
- Volume
- 33
- Issue
- 6
- Pages
- 1214-1224
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2073207619
- Cited by
- 118
- References
- 115
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS046379, R01NS046379)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, cerebral edema, inflammation, brain tumors, bacterial meningitis, ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, traumatic brain injury, spinal cord injury, methylprednisolone, adverse effects
- MeSH terms
- Brain Edema, Brain Neoplasms, Central Nervous System Diseases, Central Nervous System Infections, Cerebrovascular Disorders, Glucocorticoids, Humans, Myasthenia Gravis, Trauma, Nervous System
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