The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients
Abstract
BACKGROUND: Dipeptide alanyl-glutamine is a commonly used substrate in major trauma patients. Its importance and effects are widely discussed; as yet, it has not been elucidated whether its administration influences glucose homeostasis. OBJECTIVE: We studied the effect of alanyl-glutamine administration on insulin resistance. DESIGN: Prospective, randomized, controlled trial. SETTING: Intensive care unit of a tertiary level hospital. PATIENTS: Multiple-trauma patients. INTERVENTIONS: Patients were randomized into two groups and assigned to receive parenterally an equal dose of amino acids either with alanyl-glutamine in the dose of 0.4 g x kg body weight(-1) x 24 hrs(-1) (group AG) or without alanyl-glutamine (control group C). This regimen started 24 hrs after injury and continued for 7 days. To assess insulin sensitivity, we performed an euglycemic clamp on day 4 and day 8 after injury. MEASUREMENTS AND MAIN RESULTS: We randomized 40 patients, 20 into each group. At day 4, insulin-mediated glucose disposal was higher in group AG (2.4 +/- 0.7 mg x kg(-1) x min(-1) glucose), with significant difference from group C (1.9 +/- 0.6 mg x kg(-1) x min(-1), p = .044). At day 8, glucose disposal was higher in group AG (2.2 +/- 0.7 mg x kg(-1) x min(-1) glucose), with significant difference in comparison with group C (1.2 +/- 0.6, p < .001). Diminution of the main glucose homeostasis variables in group C between days 4 and 8 of the study was statistically significant (p < .001); however, differences in these variables in group AG were without statistical significance. CONCLUSIONS: Parenteral supplementation of alanyl-glutamine dipeptide was associated with better insulin sensitivity in multiple-trauma patients.
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“Under these conditions, several studies have reported that glutamine supplementation can offer a therapeutic approach for these critical illnesses145–147.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [147]
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Glutamine reliance in cell metabolism
Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021
Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
Cheng, S. C., Rhee, E. P., Larson, M. G., Lewis, G. D., McCabe, E. L., Shen, D., Palma, M. J., Roberts, L. D., Dejam, A., Souza, A. L., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.067827 · Cited by 605
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Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome
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Metadata
- Authors
- Bakalar, B., Duska, F., Pachl, J., Fric, M., Otahal, M., Pazout, J., & Andel, M.
- Affiliations
- Charles University (CZ)
- Venue
- Critical Care Medicine
- Published
- 2006-02
- Volume
- 34
- Issue
- 2
- Pages
- 381-386
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2046222793
- Cited by
- 136
- References
- 46
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 9
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- alanyl-glutamine, insulin sensitivity, insulin resistance, polytrauma, severe trauma, glucose homeostasis, euglycemic clamp, glucose disposal, intensive care
- MeSH terms
- Adult, Blood Glucose, Dipeptides, Energy Metabolism, Female, Humans, Infusions, Parenteral, Insulin Resistance, Intensive Care Units, Male, Multiple Trauma, Glucose Clamp Technique, Injury Severity Score
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