Do Children and Adolescents With ADHD Respond Differently to Atomoxetine?
Abstract
Objective Controversy exists over changes in tolerability and response to medications across the life span. Here the authors report data contrasting the efficacy and tolerability of atomoxetine between children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Method Data were analyzed for children ages 6-11 (510 atomoxetine, 341 placebo) and adolescents ages 12-17 (107 atomoxetine, 69 placebo) with DSM-IV-defined ADHD enrolled in similarly designed, double-blind, placebo-controlled trials. Efficacy measures included response rates, times to response, and mean changes from baseline to endpoint in the ADHD Rating Scale, Conners' Parent Rating Scale, and Clinical Global Impressions. Results Adolescents had lower baseline ADHD scores compared with children. There were no statistically significant differences in the overall effects on ADHD symptoms, response rates, or time to response between age groups. Children, but not adolescents, had higher rates of somnolence and headache relative to placebo. No other clinically meaningful treatment differences were seen in adverse event rates, vital signs, weight, height, laboratory values, or ECG between children and adolescents. Conclusions Acute atomoxetine treatment appears to be equally effective and tolerated in children and adolescents. These findings suggest that pharmacological differences in tolerability or ADHD symptom response are negligible between children and adolescents.
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The co-occurrence of ADHD and SUD is associated with poor treatment outcomes.
“and is associated with poor treatment outcomes”
From Treatment of Adolescents with Concurrent Substance Use Disorder and Attention-Deficit/Hyperactivity Disorder: A Systematic Review (2021) · cites this paper as [26]
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- Authors
- Wilens, T. E., Kratochvil, C., Newcorn, J. H., & Gao, H.
- Affiliations
- Nebraska Medical Center (US)
- Corresponding author
- Wilens, Timothy E
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 45
- Issue
- 2
- Pages
- 149-157
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2020147842
- Cited by
- 59
- References
- 8
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- atomoxetine, attention deficit hyperactivity disorder, children, adolescents, age differences in drug response, drug tolerability, sleepiness, headache, stimulant medication
- MeSH terms
- Atomoxetine Hydrochloride, Adolescent, Age Factors, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Male, Propylamines, Safety, Randomized Controlled Trials as Topic
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