Cited by 106Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesPharmacology and Obesity Treatment

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Comparative Effects of Methylphenidate and Mixed Salts Amphetamine on Height and Weight in Children With Attention-Deficit/Hyperactivity Disorder

PLISZKA, STEVEN R., MATTHEWS, THOMAS L., BRASLOW, KENNETH J., WATSON, MELISSA A.·2006·Journal of the American Academy of Child & Adolescent Psychiatry

DOI 10.1097/01.chi.0000205702.48324.fd

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Abstract

Objective To determine whether methylphenidate (MPH) and mixed salts amphetamine (MSA) have different effects on growth in children with attention-deficit/hyperactivity disorder.Method Patients treated for at least 1 year with MPH or MSA were identified. A linear regression was performed to determine the effect of stimulant type, patient gender, cumulative stimulant dose, and length of time in treatment on change in Z scores for height. A subset of patients was identified who had 3 years of consistent stimulant treatment on either MSA or MPH. Repeated-measures analyses of variance were performed to examine the effects of time and medication type on Z scores for weight, height, and body mass index.Results The linear regression showed no effect of stimulant type, drug holidays, or length of time of treatment on change in height Z score. Cumulative dose of stimulant had a small (-0.26) relationship to change in height Z scores. For patients treated for 3 years, there were no effects of stimulant or time on height Z scores. MSA produced more decrease in weight and body mass index Z scores than MPH; all of the subjects were heavier than average at baseline.Conclusion MSA and MPH did not differ in their effects on height. MSA had more of an effect on weight than MPH, although the effect was modest in magnitude and may be of limited clinical significance.

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Authors: PLISZKA, S. R., MATTHEWS, T. L., BRASLOW, K. J., & WATSON, M. A.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Corresponding author: PLISZKA, STEVEN R.
ORCID: PLISZKA, STEVEN R.
Venue: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
Published: 2006-05
Volume: 45
Issue: 5
Pages: 520-526
ISSN: 0890-8567 (ISSN-L)
DOI: 10.1097/01.chi.0000205702.48324.fd
OpenAlex: W2078945716
Cited by: 106
References: 15
Citations by year: 2026: 3 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 7
FWCI: 9.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords: methylphenidate, attention deficit hyperactivity disorder, stimulant medication, child growth, height, weight, body mass index, drug holidays
MeSH terms: Adolescent, Amphetamines, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Body Height, Body Weight, Child, Clinical Trials as Topic, Delayed-Action Preparations, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Long-Term Care, Male, Methylphenidate, Retrospective Studies, Sex Factors, Body Mass Index, Adverse Drug Reaction Reporting Systems

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Comparative Effects of Methylphenidate and Mixed Salts Amphetamine on Height and Weight in Children With Attention-Deficit/Hyperactivity Disorder

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