The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Maternal Hyperthermia and the Risk for Neural Tube Defects in Offspring: Systematic Review and Meta-Analysis
Abstract
BACKGROUND: In animals, excessive core body temperatures have been documented to cause malformations; neural tube defects (NTDs) are among the most frequently reported. In humans, data are inconclusive and often conflicting. The objective of our report is to determine the risk for neural tube defects associated with maternal hyperthermia in early pregnancy. METHODS: We conducted a systematic review and meta-analysis to evaluate available evidence on this topic in humans. MEDLINE, EMBASE, references from published reports, and biologic abstracts from meetings were searched for relevant studies. Reviewers evaluated all the retrieved articles and extracted the relevant data. Individual and summary odds ratios and relative risks were calculated using the Mantel-Haenszel method. RESULTS: Fifteen studies, reporting on 1,719 cases and 37,898 noncases, were included in the meta-analysis. The overall odds ratio for neural tube defects associated with maternal hyperthermia was 1.92 (95% confidence interval = 1.61-2.29). When analyzed separately, the 9 case-control studies had an odds ratio of 1.93 (1.53-2.42). The summary relative risk for the 6 cohort studies was 1.95 (1.30-2.92). CONCLUSIONS: Maternal hyperthermia in early pregnancy is associated with increased risk for neural tube defects and may be a human teratogen.
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Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
Primary, Secondary, and Meta-Analysis of Research
GLASS, G. V. (1976) · Educational Researcher · doi:10.3102/0013189x005010003 · Cited by 4,890
A Nonparametric “Trim and Fill” Method of Accounting for Publication Bias in Meta-Analysis
Duval, S., & Tweedie, R. (2000) · Journal of the American Statistical Association · doi:10.1080/01621459.2000.10473905 · Cited by 2,955
Cited by
H1N1 2009 influenza virus infection during pregnancy in the USA
Jamieson, D. J., Honein, M. A., Rasmussen, S. A., Williams, J. L., Swerdlow, D. L., Biggerstaff, M. S., Lindstrom, S., Louie, J. K., Christ, C. M., Bohm, S. R., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61304-0 · Cited by 1,361
Wattjes, M. P., Ciccarelli, O., Reich, D. S., Banwell, B., de Stefano, N., Enzinger, C., Fazekas, F., Filippi, M., Frederiksen, J., Gasperini, C., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00095-8 · Cited by 674
Copp, A. J., Adzick, N. S., Chitty, L. S., Fletcher, J. M., Holmbeck, G. N., & Shaw, G. M. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.7 · Cited by 649
Greene, N. D. E., & Copp, A. J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170354 · Cited by 629
Effects of influenza on pregnant women and infants
Rasmussen, S. A., Jamieson, D. J., & Uyeki, T. M. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.068 · Cited by 431
Metadata
- Authors
- Moretti, M. E., Bar-Oz, B., Fried, S., & Koren, G.
- Venue
- Epidemiology
- Published
- 2005-03
- Volume
- 16
- Issue
- 2
- Pages
- 216-219
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W2076256233
- Cited by
- 308
- References
- 3
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moretti, M. E., Bar-Oz, B., Fried, S., & Koren, G. (2005). Maternal Hyperthermia and the Risk for Neural Tube Defects in Offspring: Systematic Review and Meta-Analysis. Epidemiology. https://doi.org/10.1097/01.ede.0000152903.55579.15
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