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Cited by 52Autism Spectrum Disorder ResearchChild and Adolescent Psychosocial and Emotional DevelopmentSchizophrenia research and treatment

Variation in incidence of neurodevelopmental disorders with season of birth

Atladóttir, Hjördís Ósk, Parner, Erik T., Schendel, Diana, Dalsgaard, Søren, Thomsen, Per Hove, Thorsen, Poul·2007·Epidemiology
DOI 10.1097/01.ede.0000254064.92806.13
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Abstract

BACKGROUND: The etiologies of autism spectrum disorder and many neurodevelopmental disorders are largely unknown. The detection of a seasonal variation of birth of children diagnosed with a certain disorder could suggest etiological factors that follow a seasonal pattern. We examined the seasonal variation of births of children diagnosed with any of 4 common childhood neuropsychiatric disorders: autism spectrum disorder, hyperkinetic disorder, Tourette syndrome, and obsessive-compulsive disorder. METHODS: The study cohort consisted of all children born in Denmark from 1990 through 1999 identified in the Danish Medical Birth Register (n = 669,995). Outcome data consisted of both inpatient and outpatient diagnoses reported to the Danish National Psychiatric Registry from 1995 through 2004 using the International Classification of Diseases, 10th edition, diagnostic coding system. Logistic regression combined with spline (a smoothing method) was used to estimate the variation with season of birth for each disorder. Estimates of risk of each disorder with season of birth were adjusted for differences in follow-up time and change in incidence over time. RESULTS: No convincing variations in season of birth were observed for any of the 4 disorders, or for the autism-spectrum-disorder subtypes. CONCLUSION: Although we cannot rule out the possibility of seasonal variation of birth for a range of childhood neurodevelopmental disorders, we find little evidence that seasonal environmental factors are related to these disorders.

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  • Atladottir et al. (2007) found no association between season of conception or birth and incidence rate of ASD and ASD subcategories in a cohort born in Denmark between 1990 and 1999.

    “Lastly, Atladottir et al. (2007) found no association between season of conception or birth on incidence rate of ASD and ASD subcategories in a cohort born in Denmark between 1990 and 1999 [77].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [77]

  • Not all studies showed an association between season of birth and risk of autism.

    “Not all studies showed an association between season of birth and risk of autism [64,77,79,81,83,84,85,86].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [77]

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Authors
Atladóttir, H. Ó., Parner, E. T., Schendel, D., Dalsgaard, S., Thomsen, P. H., & Thorsen, P.
Affiliations
  • Aarhus University (DK)
  • Centers for Disease Control and Prevention (US)
  • Aarhus University Hospital (DK)
Corresponding author
  • Atladóttir, Hjördís Ósk
  • Parner, Erik T.
  • Thorsen, Poul
ORCID
Venue
Epidemiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-03
Volume
18
Issue
2
Pages
240-245
ISSN
1044-3983 (ISSN-L)
DOI
10.1097/01.ede.0000254064.92806.13
OpenAlex
W2118396059
Cited by
52
References
26
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 4 · 2016: 5 · 2014: 6 · 2013: 1 · 2012: 4
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Locations
  • Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
season of birth, neurodevelopmental disorders, autism spectrum disorder, hyperkinetic disorder, Tourette syndrome, obsessive-compulsive disorder, seasonal variation, environmental risk factors
MeSH terms
Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Child, Denmark, Tourette Syndrome, Humans, Obsessive-Compulsive Disorder, Seasons, Cohort Studies, Incidence, Proportional Hazards Models, Parturition

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