CoChat
Sign Up
Cited by 49Autism Spectrum Disorder ResearchAssisted Reproductive Technology and Twin PregnancySexual Differentiation and Disorders

Variation in season of birth in singleton and multiple births concordant for Autism Spectrum Disorders

Lee, Li‐Ching, Newschaffer, Craig J., Lessler, Justin T., Lee, Brian K., Shah, Rashmi, Zimmerman, Andrew W.·2008·Paediatric and Perinatal Epidemiology
DOI 10.1111/j.1365-3016.2007.00919.x
Open this paper in CoChat — free account

Abstract

Summary: Patterns of seasonal variation in births in some neuropsychiatric conditions have been found in previous research; however, no study to date has examined these disorders for seasonal variation in singletons and multiple births separately. This study aimed to determine whether the birth date distribution for individuals with autism spectrum disorders (ASD), including singletons and multiple births, differed from the general population. Two ASD case groups were studied: 907 singletons and 161 multiple births concordant for ASD. Two control groups were obtained from registered births of singletons and multiples. Results of the non‐parametric time‐series analyses, where day of birth was used, suggested there were three peaks in ASD singletons and ASD concordant multiple births. Roughly, the peaks were in April, June and October for singletons and about 2–4 weeks earlier in multiples. Results from multivariable Poisson regression, where month of birth was used, indicated that ASD concordant multiple births in males tended to be higher than expected in March, May and September (with borderline statistical significance), but were 87% less in December (P < 0.05), as compared with January. Overall, the patterns of relative risk estimates from Poisson regression are similar to findings from the non‐parametric time‐series approach, but are not exactly congruent. It is important to note that indications of seasonality may be sensitive to the selection of time cut‐points and therefore an arbitrary binning of time can either mask existing trends or falsely indicate the presence of a trend. The presence of seasonal trends in ASD singletons and concordant multiple births suggests a role for non‐heritable factors operating during the pre‐ or perinatal period, even among cases with a genetic susceptibility.

Integrity signals

Registry

Crossref · 10.1111/j.1365-3016.2007.00919.x

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Spring birth has been associated with increased risk of autism in studies conducted in Canada, Japan, the US, Sweden, and the UK.

    “Spring birth has been associated with increased risk of autism in studies conducted in Canada [92], Japan [91], the US [82], Sweden [78,90], and the UK [76].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [82]

  • Lee et al. (2008) reported three peaks during spring, summer and autumn months in singleton and multiple births concordant with ASD, and an 87% decreased risk for multiple births concordant for ASD in males in winter compared to other seasons (relative risk 0.18, 95% CI 0.04, 0.82; p < 0.05).

    “Lee et al. (2008) reported three peaks during spring, summer and autumn months in singleton and multiple births concordant with ASD (n = 1051), and an 87% decreased risk for multiple births concordant for ASD in males in winter (December) compared to other seasons [relative risk 0.18, 95% CI 0.04, 0.82; p < 0.05) [82].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [82]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Lee, L., Newschaffer, C. J., Lessler, J. T., Lee, B. K., Shah, R., & Zimmerman, A. W.
Affiliations
  • Johns Hopkins University (US)
  • Kennedy Krieger Institute (US)
Corresponding author
Lee, Li‐Ching
ORCID
Venue
Paediatric and Perinatal Epidemiology
Publisher
Wiley
Published
2008-02-20
Volume
22
Issue
2
Pages
172-179
ISSN
  • 0269-5022 (ISSN-L)
  • 1365-3016
DOI
10.1111/j.1365-3016.2007.00919.x
OpenAlex
W2134399039
Cited by
49
References
38
Citations by year
2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 9
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Paediatric and Perinatal Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (U10/CCU320408-05)
  • National Institute of Mental Health (MH 64547, R01MH064547)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
autism spectrum disorder, season of birth, seasonal variation, multiple births, concordant twins, singletons, birth month, perinatal factors, genetic susceptibility, birth date distribution
MeSH terms
Autistic Disorder, Birth Rate, Child, Female, Humans, Male, Multiple Birth Offspring, Pregnancy, Seasons, Multivariate Analysis, Poisson Distribution, Sex Distribution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review