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Cited by 250Respiratory viral infections researchPneumonia and Respiratory InfectionsLiterature Analysis and Criticism

National disease burden of respiratory viruses detected in children by polymerase chain reaction

HENRICKSON, KELLY J., HOOVER, SUSAN, KEHL, K. SUE, HUA, WEIMIN·2004·Pediatric Infectious Disease Journal
DOI 10.1097/01.inf.0000108188.37237.48
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Abstract

BACKGROUND: The epidemiology of community-acquired respiratory viruses at the Children's Hospital of Wisconsin between 1996 and 1998 was examined with molecular [multiplex (M) PCR] and standard virologic methods. METHODS AND RESULTS: A total of 3325 patients with lower respiratory infection (LRI) [bronchiolitis (42%), pneumonia (38%) and croup (12%)] were identified. It is estimated that 545,000 LRI hospitalizations occur each year in the United States in children younger than 18 years old (viral, 428,000; pneumonia, 221,000; bronchiolitis, 222,000; croup, 65,000), including a continued increase in bronchiolitis hospitalizations (47.8/1000; <1 year). The most common viruses detected each year in hospitalized children included respiratory syncytial virus (A and B; 117,000), parainfluenza virus (PIV-1 and -2, 48 000; PIV-3, 18,000) and influenza (A and B, 39,000). With multiplex reverse transcription polymerase chain reaction (MPCR), different patient populations demonstrated different LRI epidemiology in relation to specific syndromes and viral causes. At least 21% of LRI hospitalizations were in children with significant medical problems.PIVs were detected much more frequently in immunocompromised children than in previously healthy children (33% vs. 16%). Similarly 15% of respiratory syncytial virus was detected between May and October, mostly in immunocompromised children. Influenza caused 19% of bronchiolitis in previously healthy children, and no virus could be reliably predicted based on clinical presentation, including wheezing. Of children hospitalized for LRI, 40% tested positive for the seven most common respiratory viruses by MPCR. CONCLUSIONS: Work is under way to expand the number of viruses detected by MPCR and to determine whether newly discovered viruses, such as human metapneumovirus, contribute to the burden of pediatric LRI hospitalizations.

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  • Airway epithelial cells regulate both innate and adaptive immunity through production of functional molecules and physical interactions with cells of the immune system.

    “Airway epithelial cells regulate both innate and adaptive immunity through production of functional molecules and physical interactions with cells of the immune system.”

    From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [108]

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Authors
HENRICKSON, K. J., HOOVER, S., KEHL, K. S., & HUA, W.
Affiliations
Children's Hospital of Wisconsin (US)
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-01
Volume
23
Issue
1
Pages
S11-S18
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/01.inf.0000108188.37237.48
OpenAlex
W2009787072
Cited by
250
References
32
Citations by year
2025: 5 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 17 · 2012: 19
FWCI
8.78
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
Keywords
respiratory viruses, lower respiratory tract infection, pediatric hospitalization, bronchiolitis, pneumonia, croup, respiratory syncytial virus, parainfluenza virus, influenza, immunocompromised children, disease burden, human metapneumovirus, wheezing
MeSH terms
Adolescent, Child, Child, Preschool, Female, Hospitals, Pediatric, Humans, Infant, Influenza, Human, Male, Orthomyxoviridae, Respirovirus Infections, Respiratory Tract Infections, Retrospective Studies, United States, Cohort Studies, Incidence, Polymerase Chain Reaction, Age Distribution, Sex Distribution, Respirovirus, Risk Assessment

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