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Cited by 27Respiratory viral infections researchViral Infections and Immunology ResearchInflammation biomarkers and pathways

Local Production of Inflammatory Mediators During Childhood Parainfluenza Virus Infection

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El Feghaly, Rana E., McGann, Lindsay, Bonville, Cynthia A., Branigan, Patrick J., Suryadevera, Manika, Rosenberg, Helene F., Domachowske, Joseph B.·2010·Pediatric Infectious Disease Journal
DOI 10.1097/inf.0b013e3181d5da2aPMC PMC3417758
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Abstract

OBJECTIVE: To describe the clinical manifestations of parainfluenza virus (PIV) infection and to characterize biochemical markers of PIV disease severity. PATIENTS AND METHODS: We reviewed the medical records of 165 children who had a nasal wash culture positive for PIV at our institution between 1998 and 2008. Nasal wash samples were assayed for 26 inflammatory mediators using Luminex bead proteomics. RESULTS: A total of 153 patients, ages 2 weeks to 12 years, with single virus infection were included in our final analysis. Fifty-two patients were infected with PIV1, 19 with PIV2, 74 with PIV3, and 8 with PIV4. Lower respiratory tract infection (LRTI) was diagnosed in 67 (44%) patients, 21 (14%) had laryngotracheobronchitis, and 49 (32%) had an upper respiratory infection other than laryngotracheobronchitis. LRTI was diagnosed in 54% of patients infected with PIV3, 35% of those infected with PIV1, 26% of those with PIV2, and 50% of those with PIV4. Compared with uninfected control patients, PIV-infected patients had higher nasal wash concentrations of interleukin-6, CX-chemokine ligand 8 (CXCL8 or interleukin-8), CCL3 (macrophage inflammatory protein-1alpha), CCL4 (macrophage inflammatory protein-1beta), CXCL9 (monokine induced by interferon gamma), and CCL5 (regulated upon activation, normal T cell expressed and secreted (RANTES). Patients with LRTI, moderate or severe illness, and PIV 1 or 3 (respirovirus) infection had higher nasal wash concentrations of CXCL8 when compared with patients with upper respiratory infection, mild illness, or PIV 2 and 4 (rubulavirus) infection (P < 0.05). CONCLUSIONS: PIV infection causes a spectrum of illnesses associated with the expression and release of several proinflammatory mediators. Of note, elevated concentrations of CXCL8 in nasal wash samples are associated with more severe forms of PIV disease.

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  • Upper airway disorders such as occupational rhinitis, chronic rhinosinusitis, and nasal polyposis are linked to lower airway disorders such as asthma.

    “the observation that upper airway disorders such as occupational rhinitis, chronic rhinosinusitis, and nasal polyposis are linked to lower airway disorders such as asthma (reviewed in reference 61).”

    From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [61]

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Authors
El Feghaly, R. E., McGann, L., Bonville, C. A., Branigan, P. J., Suryadevera, M., Rosenberg, H. F., & Domachowske, J. B.
Affiliations
  • SUNY Upstate Medical University (US)
  • National Institutes of Health (US)
Corresponding author
  • McGann, Lindsay
  • Bonville, Cynthia A.
  • Suryadevera, Manika
  • Domachowske, Joseph B.
ORCID
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-04
Volume
29
Issue
4
Pages
e26-e31
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/inf.0b013e3181d5da2a
PMC
PMC3417758
OpenAlex
W2075490467
Cited by
27
References
41
Citations by year
2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 6
FWCI
2.79
Type
journal article
Language
en
Open access
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (Z01-AI-000943)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
parainfluenza virus, pediatric respiratory infection, inflammatory mediators, nasal wash, interleukin-8, lower respiratory tract infection, croup, disease severity, inflammatory cytokines, RANTES, CCL3, CXCL9, parainfluenza virus type 3, parainfluenza virus 1, Rubulavirus
MeSH terms
Bronchitis, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Laryngitis, Parainfluenza Virus 1, Human, Parainfluenza Virus 2, Human, Parainfluenza Virus 3, Human, Respiratory Tract Infections, Severity of Illness Index, Tracheitis, Interleukin-8, Nasal Lavage Fluid, Paramyxoviridae Infections, Inflammation Mediators, Parainfluenza Virus 4, Human

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