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Cited by 92Treatment of Major DepressionStress Responses and CortisolDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Lipid Metabolism and Insulin Resistance in Depressed Patients: Significance of Weight, Hypercortisolism, and Antidepressant Treatment

Kopf, Daniel, Westphal, Sabine, Luley, Claus W., Ritter, Susanne, Gilles, Maria, Weber-Hamann, Bettina, Lederbogen, Florian, Lehnert, Hendrik, Henn, Fritz A., Heuser, Isabella, Deuschle, Michael·2004·Journal of Clinical Psychopharmacology
DOI 10.1097/01.jcp.0000138762.23482.63
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Abstract

Major depression increases cardiovascular risk despite lower cholesterol levels. Little is known about effects of antidepressants on metabolic risk factors. We studied lipoprotein composition, insulin sensitivity (quantitative insulin sensitivity check index), and saliva cortisol in 78 depressed patients before and after 35 days of amitriptyline or paroxetin treatment. Data were analyzed by principal component factor analyses and analysis of variance (ANOVA). At baseline, quantitative insulin sensitivity check index was inversely correlated with cortisol (r = −0.46; P = 0.005) in normal weight patients, with body mass index in overweight patients (r = −0.50; P < 0.001). In overweight patients, hypercortisolemia correlated inversely with total and low density lipoprotein cholesterol (eg, cortisol at 4:00 PM and low density lipoprotein cholesterol: r = −0.49, P = 0.002). After treatment, quantitative insulin sensitivity check index was unchanged. Triglycerides increased in responders to amitriptyline only (P < 0.05). Parameters of cholesterol metabolism improved slightly without differences between treatment groups (eg, high density lipoprotein: pre 43.5 ± 12.0; post 47.6 ± 13.0 mg/dL; P = 0.01; low density lipoprotein triglycerides, a measure of low density lipoprotein atherogenicity: pre 458 ± 120; post 415 ± 130 mg/g; P < 0,01). The inverse correlation of cortisol and cholesterol, at least in the obese subgroup, proposes a mechanism for the known association of depression with low cholesterol. As determinants of plasma lipids in major depression, we identified body mass index, insulin sensitivity, and cortisol. Although uncontrolled, our data suggest that treatment of depression exerts a mainly beneficial effect on lipid regulation. Abbreviations: AMI = amitriptyline, BMI = body mass index, DSM IV = Diagnostic and Statistical Manual, IVth revision, HAMD = hamilton depression scale,HDL= high density lipoprotein, hypothalamus-pituitaryadrenal axis, LDL = low density lipoprotein, PAR = paroxetin, PPARa = peroxisome proliferation activator receptor a, QUICKI = quantitative insulin sensitivity check index, SSRI = selective serotonine reuptake inhibitor, TCA = tricyclic antidepressant, VLDL = very low density lipoprotein.

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Crossref · 10.1097/01.jcp.0000138762.23482.63

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Metadata

Authors
Kopf, D., Westphal, S., Luley, C. W., Ritter, S., Gilles, M., Weber-Hamann, B., Lederbogen, F., Lehnert, H., Henn, F. A., Heuser, I., & Deuschle, M.
Affiliations
  • Central Institute of Mental Health (DE)
  • Freie Universität Berlin (DE)
  • Otto-von-Guericke-Universität Magdeburg (DE)
Corresponding author
  • Kopf, Daniel
  • Ritter, Susanne
  • Gilles, Maria
  • Weber-Hamann, Bettina
  • Lederbogen, Florian
  • Henn, Fritz A.
  • Deuschle, Michael
ORCID
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-10
Volume
24
Issue
5
Pages
527-531
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/01.jcp.0000138762.23482.63
OpenAlex
W1976905142
Cited by
92
References
23
Citations by year
2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 3
FWCI
3.76
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
major depressive disorder, lipid metabolism, insulin resistance, cortisol, hypercortisolism, amitriptyline, paroxetine, lipoproteins, LDL cholesterol, HDL cholesterol, triglycerides, body mass index, obesity, cardiovascular risk, hypothalamic-pituitary-adrenal axis, QUICKI, cholesterol lowering
MeSH terms
Adult, Aged, Aged, 80 and over, Amitriptyline, Analysis of Variance, Antidepressive Agents, Blood Glucose, Cholesterol, Circadian Rhythm, Coronary Disease, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin Resistance, Lipids, Lipoproteins, Male, Middle Aged, Obesity, Pituitary-Adrenal System, Risk Factors, Triglycerides, Body Mass Index, Paroxetine, Metabolic Syndrome

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