The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Bone Mineral Density and Its Relationship to Prolactin Levels in Patients Taking Antipsychotic Treatment
Open accessAbstract
Antipsychotic treatment is frequently associated with elevated prolactin levels. Raised prolactin levels have been linked with osteoporosis. The objective of this study is to determine whether patients taking antipsychotics show reduced bone mineral density (BMD), and whether this is associated with prolactin levels. BMD (standardized as z scores) was compared using dual x-ray absorptiometry of the lumbar spine and hip in patients taking antipsychotics (n = 102, mean age: 46.0, SD: 13.1, 47% male, median treatment duration: 3.0 years) to matched reference controls. Levels of prolactin, markers of bone metabolism, and risk factors for osteoporosis were measured. Mean BMD was not significantly reduced, other than the total spine score for black males (mean z score: -0.88, P = 0.00001). BMD was correlated with body mass index but there was no correlation with prolactin. BMD was not correlated with prolactin levels and showed no clinically significant reduction. The low BMD in black males warrants further investigation.
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Some studies found a relationship between the use of prolactin-raising medication and low bone mineral density in patients with chronic schizophrenia, while others failed to find a relationship between prolactin, antipsychotics and osteoporosis.
“Some studies (490-493) found a relationship between the use of prolactin-raising medication and low BMD in patients with chronic schizophrenia, while others (474,489,494-498) failed to find a relationship between prolactin, AP and osteoporosis.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [496]
A previous study did not find correlation between prolactin levels and BMD measures.
“Although a previous study did not find correlation between prolactin levels and BMD measures (5)”
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Diagnosis of osteoporosis and assessment of fracture risk
Kanis, J. А. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08761-5 · Cited by 2,266
Updated Data on Proximal Femur Bone Mineral Levels of US Adults
Looker, A. C., Wahner, H. W., Dunn, W. L., Calvo, M. S., Harris, T. B., Heyse, S. P., Johnston Jr, C. C., & Lindsay, R. (1998) · Osteoporosis International · doi:10.1007/s001980050093 · Cited by 1,121
Meaney, A. M., Smith, S., Howes, O. D., O'Brien, M., Murray, R. M., & O'Keane, V. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.184.6.503 · Cited by 217 · cited 6×
“A previous report suggested that patients receiving longterm antipsychotics show reduced bone mineral density (BMD), equivalent to osteopenia or osteoporosis in 57% of males and 32% of females.(1) Osteoporotic fractures were reported in 23% of males on psychotropics.”
BackgroundMethodResultInfluentialSelf-citationDecreased Bone Mineral Density in Medicated Psychiatric Patients
Halbreich, U. M., Rojansky, N., Palter, S. F., Hreshchyshyn, M. M., Kreeger, J., Bakhai, Y., & Rosan, R. C. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199509000-00011 · Cited by 193
Sex differences in peak adult bone mineral density
Kelly, P. J., Twomey, L. T., Sambrook, P. N., & Eisman, J. A. (1990) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650051112 · Cited by 151
Bone mineral density reference databases for American men and women
Kelly, T. (1990) · Journal of Bone and Mineral Research · Cited by 98
Abraham, G., Paing, W. W., Kaminski, J., Joseph, A., Kohegyi, E., & Josiassen, R. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1618 · Cited by 82
Bone mineral density and prolactin associations in patients with chronic schizophrenia
Abraham, G., Halbreich, U. M., Friedman, R. H., & Josiassen, R. C. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00321-8 · Cited by 48
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DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
Byerly, M., Suppes, T., Tran, Q.-V., & Baker, R. A. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31815ac4e5 · Cited by 153
O'Keane, V. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107088439 · Cited by 126
Self-citationHigh bone turnover but normal bone mineral density in women suffering from schizophrenia
Bergemann, N., Parzer, P., Mundt, C., & Auler, B. (2008) · Psychological Medicine · doi:10.1017/s003329170800319x · Cited by 37
Eriksson, R., Broberg, B. V., Ishøy, P. L., Bak, N., Andersen, U. B., Jørgensen, N. R., Knop, F. K., & Ebdrup, B. H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00781 · Cited by 26
Metadata
- Authors
- Howes, O. D., Wheeler, M. J., Meaney, A.-M., O'Keane, V., Fogelman, I., Blake, G., Murray, R. M., & Smith, S.
- Affiliations
- St Thomas' Hospital (GB)
- Corresponding author
- Howes, Oliver D.
- Murray, Robin M.
- Smith, Shubulade
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2005-06
- Volume
- 25
- Issue
- 3
- Pages
- 259-261
- ISSN
- 0271-0749 (ISSN-L)
- PMC
- PMC3666284
- OpenAlex
- W2057652738
- Cited by
- 64
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 8
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- bone mineral density, prolactin, antipsychotic drugs, osteoporosis, bone turnover markers, body mass index, racial differences, Black men, lumbar spine, hip
- MeSH terms
- Adult, Ambulatory Care, Female, Humans, Male, Middle Aged, Prolactin, Risk Factors, Antipsychotic Agents, Bone Density
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