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Response of Emotional Unawareness After Stroke to Antidepressant Treatment
Abstract
Objective Unawareness of impairment (anosognosia) is a phenomenon associated with right hemisphere lesions. Unawareness of emotion has rarely been studied. Methods Patients (N = 50) with poststroke major depression were administered the Toronto, Ontario, Canada, Alexithymia Scale to assess impairment in identifying feelings (F1), describing feelings (F2), and externally oriented thinking (F3). After eight weeks of treatment with sertraline or fluoxetine, patients were reassessed. Results Alexithymia was significantly associated with right hemisphere lesions. Patients with alexithymia had a significant improvement in identifying and describing feelings, but not in externally oriented thinking. In addition, cognitive functions improved after antidepressant treatment in patients without alexithymia with left lesions only. On the contrary, functional activities of daily living and depressive symptoms improved both in patients with alexithymia and those without alexithymia. Conclusions The unawareness of emotions is a common impairment after right hemisphere stroke. This disorder may be significantly improved by antidepressant treatment.
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Metadata
- Authors
- Spalletta, G., Ripa, A., Bria, P., Caltagirone, C., & Robinson, R. G.
- Affiliations
- University of Rome Tor Vergata (IT)
- Fondazione Santa Lucia (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Iowa (US)
- Corresponding author
- Robinson, Robert G.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 14
- Issue
- 3
- Pages
- 220-227
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2169872906
- Cited by
- 37
- References
- 22
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Keywords
- alexithymia, stroke, post-stroke depression, right hemisphere damage, sertraline, fluoxetine, antidepressant treatment, anosognosia, emotional awareness, activities of daily living
- MeSH terms
- Activities of Daily Living, Affective Symptoms, Aged, Agnosia, Antidepressive Agents, Awareness, Cognition, Major Depressive Disorder, Depressive Disorder, Major, Emotions, Fluoxetine, Follow-Up Studies, Humans, Internal-External Control, Mental Status Schedule, Personality Inventory, Sertraline, Stroke
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