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Tadalafil has No Detrimental Effect on Human Spermatogenesis or Reproductive Hormones
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“The investigators concluded that daily dosing with tadalafil 10 or 20 mg produced no clinically relevant effect on spermatogenesis.”
From Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles (2004) · cites this paper as [8]
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Research works printed but not linked: 16
- Brock, 2002, Efficacy and safety of tadalafil in the treatment of erectile dysfunction: results of integrated analyses, J Urol, 168, 1332, 10.1016/S0022-5347(05)64442-4 · DOI · Paper page
- Fawcett, 2000, Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A, Proc Natl Acad Sci USA, 97, 3702, 10.1073/pnas.050585197 · DOI
- Baxendale, 2001, Phosphodiesterase type 11 (PDE11) cellular localisation: progress towards defining a physiological role in testis and/or reproduction, J Urol, 165, 340
- Pocock, 1975, Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial, Biometrics, 31, 103, 10.2307/2529712 · DOI · Paper page
- Tielemans, 1997, Intraindividual variability and redundancy of semen parameters, Epidemiology, 8, 99, 10.1097/00001648-199701000-00016 · DOI
- Bremner, 1976, Colchicine and testicular function in man, N Engl J Med, 294, 1384, 10.1056/NEJM197606172942508 · DOI
- Gyllenborg, 1999, Secular and seasonal changes in semen quality among young Danish men: a statistical analysis of semen samples from 1927 donor candidates during 1977–1995, Int J Androl, 22, 28, 10.1046/j.1365-2605.1999.00137.x · DOI
- Guzick, 2001, Sperm morphology, motility, and concentration in fertile and infertile men, N Engl J Med, 345, 1388, 10.1056/NEJMoa003005 · DOI · Paper page
- Mieusset, 1985, Inhibiting effect of artificial cryptorchidism on spermatogenesis, Fertil Steril, 43, 589, 10.1016/S0015-0282(16)48502-X · DOI
- Mieusset, 1987, Effects of artificial cryptorchidism on sperm morphology, Fertil Steril, 47, 150, 10.1016/S0015-0282(16)49951-6 · DOI
- Meistrich, 1997, Rapid recovery of spermatogenesis after mitoxantrone, vincristine, vinblastine, and prednisone chemotherapy for Hodgkin's disease, J Clin Oncol, 15, 3488, 10.1200/JCO.1997.15.12.3488 · DOI
- Shafik, 1991, Testicular suspension: effect on testicular function, Andrologia, 23, 297, 10.1111/j.1439-0272.1991.tb02565.x · DOI
- Coutinho, 2000, Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study, Contraception, 61, 61, 10.1016/S0010-7824(99)00117-1 · DOI
- Nelson, 1957, The effect of therapeutic dosages of nitrofurantoin (furadantin) upon spermatogenesis in man, J Urol, 77, 275, 10.1016/S0022-5347(17)66553-4 · DOI
- Levi, 1979, Male infertility due to sulphasalazine, Lancet, 2, 276, 10.1016/S0140-6736(79)90292-7 · DOI
- Wu, 1999, Oral progestogen combined with testosterone as a potential male contraceptive: additive effects between desogestrel and testosterone enanthate in suppression of spermatogenesis, pituitary-testicular axis, and lipid metabolism, J Clin Endocrinol Metab, 84, 112, 10.1210/jc.84.1.112 · DOI
Cited by
Tadalafil in the treatment of erectile dysfunction
Coward, R., & Carson, C. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3336 · Cited by 138
Seftel, A. D. (2004) · Clinical Cardiology · doi:10.1002/clc.4960271305 · Cited by 79
Metadata
- Authors
- HELLSTROM, W. J. G., OVERSTREET, J. W., YU, A., SAIKALI, K., SHEN, W., BEASLEY, C. M., & WATKINS, V. S.
- Affiliations
- From the Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, Department of Obstetrics and Gynecology, University of California-Davis, Davis, California, ICOS Corp., Bothell, Washington, and Eli Lilly and Co., Indianapolis, Indiana
- Venue
- Journal of Urology
- Published
- 2003-09
- Volume
- 170
- Issue
- 3
- Pages
- 887-891
- ISSN
- 0022-5347
- 1527-3792
- Cited by
- 103
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
