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Cited by 406Sexual function and dysfunction studiesHormonal and reproductive studiesUrological Disorders and Treatments

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

RANDOMIZED STUDY OF TESTOSTERONE GEL AS ADJUNCTIVE THERAPY TO SILDENAFIL IN HYPOGONADAL MEN WITH ERECTILE DYSFUNCTION WHO DO NOT RESPOND TO SILDENAFIL ALONE

SHABSIGH, R., KAUFMAN, J.M., STEIDLE, C., PADMA-NATHAN, H.·2004·Journal of Urology
DOI 10.1097/01.ju.0000132389.97804.d7
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Abstract

PURPOSE: We compare the efficacy of testosterone gel (T-gel) versus placebo as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. MATERIALS AND METHODS: A randomized, placebo controlled, double-blind, parallel group, multicenter study was performed. A total of 75 hypogonadal men (18 to 80 years old, morning serum total testosterone 400 ng/dl or less) with confirmed lack of response to sildenafil monotherapy were randomized (1:1) to receive a daily dose of 1% T-gel or 5 gm placebo gel as adjunctive therapy to 100 mg sildenafil during a 12-week period. Subjects were evaluated for sexual function, primarily based on the International Index of Erectile Function (IIEF), quality of life and serum testosterone levels at baseline and weeks 4, 8 and 12. RESULTS: Testosterone treated subjects had greater improvement in erectile function compared to those who received placebo, reaching statistical significance at week 4 (4.4 vs 2.1, p = 0.029, 95.1% CI 0.3, 4.7). Similar trends were observed for improvements in orgasmic function, overall satisfaction, total IIEF score and percentage of IIEF responders. T-gel significantly (p < or =0.004) increased total and free testosterone levels throughout the study, although no significant correlations were made between testosterone levels and the IIEF at end point. CONCLUSIONS: T-gel taken with sildenafil may be beneficial in improving erectile function in hypogonadal men with erectile dysfunction who are unresponsive to sildenafil alone.

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Crossref · 10.1097/01.ju.0000132389.97804.d7

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Metadata

Authors
SHABSIGH, R., KAUFMAN, J. M., STEIDLE, C., & PADMA-NATHAN, H.
Affiliations
University of Southern California (US)
Venue
Journal of Urology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-08
Volume
172
Issue
2
Pages
658-663
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
DOI
10.1097/01.ju.0000132389.97804.d7
OpenAlex
W2121881032
Cited by
406
References
9
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 16 · 2015: 7 · 2014: 29 · 2013: 33 · 2012: 18
FWCI
25.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
testosterone gel, sildenafil, erectile dysfunction, hypogonadism, adjunctive therapy, testosterone replacement therapy, International Index of Erectile Function, serum testosterone levels, male sexual function
MeSH terms
Sildenafil Citrate, Adolescent, Adult, Aged, Aged, 80 and over, Double-Blind Method, Drug Therapy, Combination, Gels, Humans, Hypogonadism, Erectile Dysfunction, Male, Middle Aged, Phosphodiesterase Inhibitors, Piperazines, Purines, Quality of Life, Sulfones, Testosterone, Treatment Failure

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