Hypogonadotropic Hypogonadism in Men with Type 2 Diabetes
Abstract
It has recently been demonstrated that > or = one-third of men with type 2 diabetes mellitus have low testosterone concentrations associated with inappropriately low luteinizing hormone and follicle-stimulating hormone concentrations. Hypogonadotropic hypogonadism in men with type 2 diabetes is associated with obesity but not duration of diabetes, elevated glycosylated hemoglobin, or the presence of microvascular complications of diabetes. Recent data show that hypogonadotropic hypogonadism is also observed frequently in nondiabetics with the metabolic syndrome or obesity, but it is not associated with type 1 diabetes. Low testosterone concentrations in men with type 2 diabetes have also been related to a higher C-reactive protein concentrations, lower hematocrit, increased total and regional adiposity, lower bone mineral density, and erectile dysfunction. This article discusses the pathophysiology of hypogonadotropic hypogonadism in men with type 2 diabetes and its signs and symptoms. Clinical trials are required to determine whether testosterone replacement therapy alleviates insulin resistance, inflammation, and symptoms related to sexual dysfunction care.
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Low testosterone is associated with obesity, dyslipidemia, and hypertension, all of which increase the risk of cardiovascular disease.
“Low T is also associated with obesity, dyslipidemia, and hypertension, all of which increase the risk of cardiovascular disease (CVD) [5].”
Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824 · see citing works
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works
The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J., Bunnell, T. J., Tricker, R., Shirazi, A., & Casaburi, R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607043350101 · Cited by 1,659 · see citing works
DUNN, J. F., NISULA, B. C., & RODBARD, D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-58 · Cited by 1,238 · see citing works
Testosterone dose-response relationships in healthy young men
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Bhasin, D., Berman, N., Chen, X., Yarasheski, K. E., Magliano, L., Dzekov, C., et al. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1172 · Cited by 967 · see citing works
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965 · see citing works
Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., Salonen, R., & Salonen, J. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1036 · Cited by 920 · see citing works
Low Serum Testosterone and Mortality in Older Men
Laughlin, G. A., Barrett-Connor, E., & Bergstrom, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1792 · Cited by 798 · see citing works
Diabetes Mellitus as a Predictor of Cancer Mortality in a Large Cohort of US Adults
Coughlin, S. S., Calle, E. E., Teras, L. R., Petrelli, J. M., & Thun, M. J. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh161 · Cited by 795 · see citing works
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791 · see citing works
Prevalence of hypogonadism in males aged at least 45 years: the HIM study
MULLIGAN, T., FRICK, M. F., ZURAW, Q. C., STEMHAGEN, A., & MCWHIRTER, C. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.00992.x · Cited by 767 · see citing works
Khaw, K.-T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., Welch, A., & Day, N. (2007) · Circulation · doi:10.1161/circulationaha.107.719005 · Cited by 743 · see citing works
Gudmundsson, J., Sulem, P., Steinthorsdottir, V., Bergthorsson, J. T., Thorleifsson, G., Manolescu, A., Rafnar, T., Gudbjartsson, D., Agnarsson, B. A., Baker, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2062 · Cited by 723 · see citing works
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705 · see citing works
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 690 · see citing works
Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes
Dhindsa, S., Prabhakar, S., Sethi, M., Bandyopadhyay, A., Chaudhuri, A., & Dandona, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0804 · Cited by 631 · see citing works
Self-citationEnglish, K. M., Steeds, R. P., Jones, T. H., Diver, M. J., & Channer, K. S. (2000) · Circulation · doi:10.1161/01.cir.102.16.1906 · Cited by 582 · see citing works
Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Androgen Levels
Isidori, A. M., Caprio, M., Strollo, F., Moretti, C., Frajese, G., Isidori, A., & Fabbri, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6082 · Cited by 560 · see citing works
Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study.
de Liefde, I. I., van der Klift, M., Laet, C. E. D. H. D., van Daele, P. L. A., Albert Hofman, D., & Pols, H. A. P. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1909-1 · Cited by 555 · see citing works
Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes
Kapoor, D., Aldred, H., Clark, S., Channer, K. S., & Jones, T. H. (2007) · Diabetes Care · doi:10.2337/dc06-1426 · Cited by 493 · see citing works
Effects of testosterone on sexual function in men: results of a meta‐analysis
Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02350.x · Cited by 492 · see citing works
Hak, A. E., Witteman, J. C. M., de Jong, F. H., Geerlings, M. I., Albert Hofman, D., & Pols, H. A. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.8.3632 · Cited by 480 · see citing works
Low testosterone levels are common and associated with insulin resistance in men with diabetes
Grossmann, M., Thomas, M. C., Panagiotopoulos, S., Sharpe, K., MacIsaac, R. J., Clarke, S., Zajac, J. D., & Jerums, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2177 · Cited by 468 · see citing works
Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease
Webb, C. M., McNeill, J. G., Hayward, C. S., de Zeigler, D., & Collins, P. (1999) · Circulation · doi:10.1161/01.cir.100.16.1690 · Cited by 451 · see citing works
Sex hormones, inflammation and the metabolic syndrome: a population-based study
Laaksonen, D., Niskanen, L., Punnonen, K., Nyyssonen, K., Tuomainen, T., Salonen, R., Rauramaa, R., & Salonen, J. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490601 · Cited by 438 · see citing works
SHABSIGH, R., KAUFMAN, J. M., STEIDLE, C., & PADMA-NATHAN, H. (2004) · Journal of Urology · doi:10.1097/01.ju.0000132389.97804.d7 · Cited by 406 · see citing works
Acute Anti-Ischemic Effect of Testosterone in Men With Coronary Artery Disease
Rosano, G. M. C., Leonardo, F., Pagnotta, P., Pelliccia, F., Panina, G., Cerquetani, E., della Monica, P. L., Bonfigli, B., Volpe, M., & Chierchia, S. L. (1999) · Circulation · doi:10.1161/01.cir.99.13.1666 · Cited by 367 · see citing works
Vermeulen, A. (1993) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.5.1140 · Cited by 346 · see citing works
KWAN, M., GREENLEAF, W. J., MANN, J., CRAPO, L., & DAVIDSON, J. M. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-557 · Cited by 339 · see citing works
Evaluation of assays available to measure free testosterone
Morley, J. E., Patrick, P., & Perry, H. M. (2002) · Metabolism · doi:10.1053/meta.2002.31975 · Cited by 309 · see citing works
Risk Factors for Hip Fracture in Middle-aged Norwegian Women and Men
Meyer, H. E., Tverdal, A., & Falch, J. A. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116622 · Cited by 308 · see citing works
Natural Androgens Inhibit Male Atherosclerosis
Alexandersen, P., Haarbo, J., Byrjalsen, I., Lawaetz, H., & Christiansen, C. (1999) · Circulation Research · doi:10.1161/01.res.84.7.813 · Cited by 251 · see citing works
Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase
Nathan, L., Shi, W., Dinh, H., Mukherjee, T. K., Wang, X., Lusis, A. J., & Chaudhuri, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051003698 · Cited by 247 · see citing works
Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., & Salonen, J. T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0970 · Cited by 230 · see citing works
Singh, A. B., Hsia, S. H., Alaupovic, P., Sinha‐Hikim, I., Woodhouse, L. J., Buchanan, T. A., Shen, R., Bross, R., Berman, N., & Bhasin, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8172 · Cited by 225 · see citing works
4 Serum bioavailability of sex steroid hormones
Pardridge, W. M. (1986) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(86)80024-x · Cited by 224 · see citing works
Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men
Tsai, E., Boyko, E. J., Leonetti, D., & Fujimoto, W. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801183 · Cited by 221 · see citing works
Yialamas, M. A., Dwyer, A. A., Hanley, E., Lee, H., Pitteloud, N., & Hayes, F. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0454 · Cited by 220 · see citing works
Dobnig, H., Piswanger-Sölkner, J. C., Roth, M., Obermayer-Pietsch, B. M., Tiran, A., Groselj‐Strele, A., Maier, E., Maritschnegg, P., Sieberer, C., & Fahrleitner‐Pammer, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0460 · Cited by 217 · see citing works
Pathogenesis of the decreased androgen levels in obese men.
Giagulli, V. A., Kaufman, J. M., & Vermeulen, A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962311 · Cited by 215 · see citing works
Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues.
Mårin, P., Krotkiewski, M., & Björntorp, P. A. (1992) · PubMed · Cited by 196 · see citing works
Corona, G., Mannucci, E., Petrone, L., Ricca, V, Balercia, G., Mansani, R., Chiarini, V, Giommi, R., Forti, G., & Maggi, M. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901391 · Cited by 189 · see citing works
Kaplan, S. A., Meehan, A. G., & Shah, A. K. (2006) · The Journal of Urology · doi:10.1016/j.juro.2006.06.003 · Cited by 185 · see citing works
Diabetes and Risk of Prostate Cancer in a Prospective Cohort of US Men
Rodriguez, C. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwh334 · Cited by 185 · see citing works
Low testosterone levels are associated with coronary artery disease in male patients with angina
Rosano, G. M. C., Sheiban, I., Massaro, R., Pagnotta, P. A., Marazzi, G., Vitale, C., Mercuro, G. G., Volterrani, M., Aversa, A., & Fini, M. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901504 · Cited by 180 · see citing works
Watanobe, H., & Hayakawa, Y. (2003) · Endocrinology · doi:10.1210/en.2003-0644 · Cited by 169 · see citing works
Association of Diabetes With Prostate Cancer Risk in the Multiethnic Cohort
Waters, K. M., Henderson, B. E., Stram, D. O., Wan, P., Kolonel, L. N., & Haiman, C. A. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp003 · Cited by 161 · see citing works
Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men.
Woodhouse, L., Gupta, N., Bhasin, M., Singh, A. B., Ross, R., Phillips, J., & Bhasin, S. (2004) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2003-031492 · Cited by 159 · see citing works
Arver, S., Dobs, A. S., Meikle, A. W., Allen, R. P., Sanders, S. W., & Mazer, N. A. (1996) · The Journal of Urology · doi:10.1016/s0022-5347(01)66141-x · Cited by 156 · see citing works
Nielsen, T. L., Hagen, C., Wraae, K., Brixen, K., Petersen, P. H., Haug, E., Larsen, R., & Andersen, M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1847 · Cited by 149 · see citing works
Testosterone Concentration in Young Patients With Diabetes
Chandel, A., Dhindsa, S., Topiwala, S., Chaudhuri, A., & Dandona, P. (2008) · Diabetes Care · doi:10.2337/dc08-0851 · Cited by 146 · see citing works
Self-citation(2008) · PubMed · Cited by 142 · see citing works
LETTER TO THE EDITOR: An Extraordinarily Inaccurate Assay for Free Testosterone Is Still with Us
Rosner, W. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7643 · Cited by 123 · see citing works
Bhatia, V., Chaudhuri, A., Tomar, R., Dhindsa, S., Ghanim, H., & Dandona, P. (2006) · Diabetes Care · doi:10.2337/dc06-0637 · Cited by 123 · see citing works
Self-citationDiagnosis of hypogonadism in the aging male
Vermeulen, A., & Kaufman, J. (2002) · The Aging Male · doi:10.1080/tam.5.3.170.176 · Cited by 116 · see citing works
Contrasting testosterone concentrations in type 1 and type 2 diabetes.
Tomar, R., Dhindsa, S., Chaudhuri, A., Mohanty, P., Garg, R., & Dandona, P. (2006) · Diabetes Care · doi:10.2337/dc06-0197 · Cited by 100 · see citing works
Self-citationHypogonadotrophic Hypogonadism in Type 2 Diabetes, Obesity and the Metabolic Syndrome
Dandona, P., Dhindsa, S., Chaudhuri, A., Bhatia, V., Topiwala, S., & Mohanty, P. (2008) · Current Molecular Medicine · doi:10.2174/156652408786733658 · Cited by 94 · see citing works
Self-citationTestosterone Replacement Therapy and Prostate Cancer
Morgentaler, A. (2007) · Urologic Clinics of North America · doi:10.1016/j.ucl.2007.08.002 · Cited by 82 · see citing works
Russell, S. H., Small, C. J., Stanley, S., Franks, S., Ghatei, M. A., & Bloom, S. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00632.x · Cited by 78 · see citing works
Contrasting Testosterone Concentrations in Type 1 and Type 2 Diabetes
Tomar, R. (2006) · Diabetes Care · doi:10.2337/diacare.2951120 · Cited by 78 · see citing works
Liu, P. Y., Wishart, S. M., Celermajer, D., Jimenez, M., di Pierro, I., Conway, A., & Handelsman, D. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480055 · Cited by 69 · see citing works
Sun, P., Cameron, A. E., Seftel, A. D., Shabsigh, R., NIEDERBERGER, C. S., & Guay, A. T. (2006) · The Journal of Urology · doi:10.1016/j.juro.2006.04.082 · Cited by 67 · see citing works
Tripathy, D., Shah, P., Lakshmy, R., & Reddy, K. (1998) · Hormone and Metabolic Research · doi:10.1055/s-2007-978950 · Cited by 66 · see citing works
Ponikowska, B., Jankowska, E. A., Maj, J., Węgrzynowska‐Teodorczyk, K., Biel, B., Reczuch, K. W., Borodulin-Nadzieja, L., Banasiak, W., & Ponikowski, P. P. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.03.072 · Cited by 50 · see citing works
The Effects of Hypogonadism on Body Composition and Bone Mineral Density in Type 2 Diabetic Patients
Dhindsa, S., Bhatia, V., Dhindsa, G., Chaudhuri, A., Gollapudi, G. M., & Dandona, P. (2007) · Diabetes Care · doi:10.2337/dc07-0337 · Cited by 47 · see citing works
Self-citationTripathy, D., Dhindsa, S., Garg, R., Khaishagi, A., Syed, T., & Dandona, P. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/154041903321648270 · Cited by 34 · see citing works
Self-citationTestosterone deficiency and the metabolic syndrome
Lunenfeld, B. (2007) · The Aging Male · doi:10.1080/13685530701390800 · Cited by 27 · see citing works
Dhindsa, S., Upadhyay, M., Viswanathan, P., Howard, S., Chaudhuri, A., & Dandona, P. (2008) · Endocrine Practice · doi:10.4158/ep.14.8.1000 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
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Epidemiology and Prevention of Prostate Cancer
Gandaglia, G., Leni, R., Bray, F., Fleshner, N. E., Freedland, S. J., Kibel, A. S., Stattin, P. E., Poppel, H. V., & Vecchia, C. L. (2021) · European Urology Oncology · doi:10.1016/j.euo.2021.09.006 · Cited by 622 · see citing works
Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117 · see citing works
Sexual dysfunction in men with type 2 diabetes
Isidro, M. L. (2012) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2011-130069 · Cited by 85 · see citing works
Bhattacharya, R. K., Khera, M., Blick, G., Kushner, H., Nguyen, D., & Miner, M. M. (2011) · BMC Endocrine Disorders · doi:10.1186/1472-6823-11-18 · Cited by 63 · see citing works
Testosterone a key factor in gender related metabolic syndrome
Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 61 · see citing works
Effect of Testosterone on Progression From Prediabetes to Diabetes in Men With Hypogonadism
Bhasin, S., Lincoff, A. M., Nissen, S. E., Wannemuehler, K. A., McDonnell, M. E., Peters, A. L., Khan, N., Snabes, M. C., Li, X., Li, G., et al. (2024) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2023.7862 · Cited by 59 · see citing works
Mayne, D., Stout, N. R., & Aspray, T. (2010) · Age and Ageing · doi:10.1093/ageing/afq081 · Cited by 56 · see citing works
El-Twab, S. M. A., Mohamed, H. M., & Mahmoud, A. M. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0503 · Cited by 54 · see citing works
Non-neoplastic diseases of the testis
Nistal, M., & Paniagua, R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-01970-5.50014-2 · Cited by 50 · see citing works
Kaya‐Sezginer, E., & Gür, S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200424161018 · Cited by 46 · see citing works
Gonzales, G. F., Gonzales‐Castañeda, C., & Gasco, M. (2013) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2013.785656 · Cited by 42 · see citing works
Kong, Z., Sudirman, S., Hsu, Y.-C., Su, C.-Y., & Kuo, H.-P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184485 · Cited by 40 · see citing works
Hypogonadism, Type-2 Diabetes Mellitus, and Bone Health: A Narrative Review
Russo, V., Chen, R., & Armamento‐Villareal, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.607240 · Cited by 40 · see citing works
Antonič, K. G., Antonič, B., Žuran, I., & Pfeifer, M. (2020) · The Aging Male · doi:10.1080/13685538.2020.1793132 · Cited by 22 · see citing works
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Demirci, İ., Haymana, C., Candemir, B., Meric, C., Yuksel, B., Eser, M., Akın, O., Akın, Ş., Gulcelik, N. E., & Sonmez, A. (2021) · Endokrynologia Polska · doi:10.5603/ep.a2021.0019 · Cited by 25 · see citing works
Santos, H. O., Cadegiani, F., & Forbes, S. C. (2022) · Clinical Therapeutics · doi:10.1016/j.clinthera.2022.06.006 · Cited by 24 · see citing works
Majumdar, S., Sinha, B., Dastidar, B. G., Gangopadhyay, K. K., Ghosal, S., Mukherjee, J. J., Mazumdar, A., Ray, S., Dasgupta, S., & Bhattacharjee, K. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108980 · Cited by 24 · see citing works
New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men
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Lee, A. M., Chu, L., Chong, C. S. Y., Chan, S., Tam, S., Lam, K. S. L., & Lam, T.-P. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.01021.x · Cited by 21 · see citing works
Khairuddin, K., Sudirman, S., Huang, L., & Kong, Z. (2020) · Applied Sciences · doi:10.3390/app10248768 · Cited by 20 · see citing works
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Cameron, J., Jain, R., Rais, M., White, A. E., Beer, T. M., Kievit, P., Winters-Stone, K., Messaoudi, I., & Varlamov, O. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.148 · Cited by 20 · see citing works
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Sudirman, S., Hsu, Y.-H., Johnson, A., Tsou, D., & Kong, Z. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s172906 · Cited by 16 · see citing works
The Interplay Between Pituitary Health and Diabetes Mellitus – The Need for ‘Hypophyseo-vigilance’
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Paruk, I. M., Pirie, F. J., Nkwanyana, N. M., & Motala, A. A. (2019) · South African Medical Journal · doi:10.7196/samj.2019.v109i12.013893 · Cited by 13 · see citing works
Ebong, P. E. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/7078 · Cited by 10 · see citing works
Amidu, N., Owiredu, W. K. B. A., Gyasi-Sarpong, C. K., Alidu, H. W., Antuamwine, B. B., & Sarpong, C. (2017) · International Journal of Impotence Research · doi:10.1038/ijir.2017.6 · Cited by 9 · see citing works
Prevalence of Low Bone Density and Comorbid Hypogonadism in Patients With Chronic Pancreatitis
Gupta, N., Singh, S., Vargas, L. M., Moore, T. E., Shostrom, V., & Boerner, B. P. (2019) · Pancreas · doi:10.1097/mpa.0000000000001257 · Cited by 8 · see citing works
Majumdar, S., Mukherjee, J. J., Ray, S., Goswami, S., Jude, E. B., Biswas, A. K., Hanumanthu, A., John, M., Sinha, B., Ghosal, S., et al. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.102191 · Cited by 7 · see citing works
The male hormone reset: how GLP-1RAs, lifestyle and testosterone transform obesity-linked problems
Antonič, K. G., & Zitzmann, M. (2025) · The Aging Male · doi:10.1080/13685538.2025.2601423 · Cited by 6 · see citing works
Miner, M. M., & Seftel, A. D. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02521.x · Cited by 5 · see citing works
Nonneoplastic Diseases of the Testis
Nistal, M., Paniagua, R., & González‐Peramato, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-54941-7.00012-8 · Cited by 5 · see citing works
Overt hypogonadism is a cardiovascular risk factor in type 2 diabetic males: An observational study
Oğuz, A., Şahin, M., Ülgen, C., Uyan, M., & Gül, K. (2021) · Andrologia · doi:10.1111/and.14271 · Cited by 4 · see citing works
Chan, Y. X., Alfonso, H. S., Fegan, P. G., Flicker, L. A., & Yeap, B. B. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01142 · Cited by 4 · see citing works
Morbidity and mortality in men: Role of androgens
Fallara, G., Pozzi, E., Corsini, C., Belladelli, F., Boeri, L., Capogrosso, P., Montorsi, F., & Salonia, A. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101662 · Cited by 5 · see citing works
Pancreatic Solid Pseudopapillary Tumor Associated with Elevated DHEA and Testosterone
Estifan, E., Cavanagh, Y., Kapoor, A., & Grossman, M. A. (2019) · Case Reports in Gastrointestinal Medicine · doi:10.1155/2019/8128376 · Cited by 3 · see citing works
Defeudis, G., Maddaloni, E., Rossini, G., Tommaso, A. M. D., Mazzilli, R., Palma, P. D., Pozzilli, P., & Napoli, N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185333 · Cited by 3 · see citing works
Abichandani, V. K., & Kalhan, A. (2023) · Chronicle of Diabetes Research and Practice · doi:10.4103/cdrp.cdrp_cdrp_20_22 · Cited by 1 · see citing works
Doustmohammadian, S., Samadanifard, S. H., Doustmohammadian, A., Doustmohammadian, N., & Abdi, H. (2013) · Archives of Advances in Biosciences · doi:10.22037/jps.v4i2.4318 · Cited by 1 · see citing works
Age-Related Testosterone Deficiency Merits Treatment
Traish, A. M. (2021) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2020.0019 · Cited by 1 · see citing works
Hypogonadism and diabetes mellitus - Implications for cardiovascular risk
Madhu, S. (2017) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-017-0573-2 · Cited by 1 · see citing works
Perspectives in Pediatric Pathology, Chapter 22. Testicular Involvement in Systemic Diseases
Nistal, M., Paniagua, R., González‐Peramato, P., & Reyes‐Múgica, M. (2014) · Pediatric and Developmental Pathology · doi:10.2350/14-09-1556-pb.1
DYSFONCTION ERECTILE DU PATIENT DIABETIQUE DE TYPE 2
Chevalier, L., & Dobremez, P. (2013)
Antonič, K. G. (2020) · Slovenian Medical Journal · doi:10.6016/zdravvestn.2921
Obesity associated hypogonadism—a growing concern in metabolic syndrome
Majumdar, S., Jacob, J. J., & Jude, E. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00054-2
Nonneoplastic diseases of the testis
Nistal, M., Paniagua, R., & González‐Peramato, P. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4327-8.00012-7
- Authors
- Dandona, P., Dhindsa, S., Chandel, A., & Chaudhuri, A.
- Affiliations
- Kaleida Health (US)
- Corresponding author
- Dandona, Paresh
- Venue
- Postgraduate Medicine
- Publisher
- Informa UK Limited
- Published
- 2009-05
- Volume
- 121
- Issue
- 3
- Pages
- 45-51
- ISSN
- 0032-5481 (ISSN-L)
- 1941-9260
- OpenAlex
- W2087772017
- Cited by
- 47
- References
- 67
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Postgraduate Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- hypogonadotropic hypogonadism, type 2 diabetes, androgen deficiency, luteinizing hormone, follicle-stimulating hormone, obesity, metabolic syndrome, C-reactive protein, adiposity, bone mineral density, erectile dysfunction, insulin resistance, testosterone replacement therapy, pathophysiology
- MeSH terms
- Diabetes Mellitus, Type 2, Follicle Stimulating Hormone, Humans, Hypogonadism, Luteinizing Hormone, Male, Radioimmunoassay, Risk Factors, Testosterone, United States, Prevalence
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