The Diabetes-Prone NZO/HlLt Strain. I. Immunophenotypic Comparison to the Related NZB/BlNJ and NZW/LacJ Strains
Open accessAbstract
New Zealand Obese (NZO)/HlLt male mice exhibit a polygenic obesity and approximately 50% develop type 2 diabetes. This strain is known to produce a variety of autoantibodies, including autoantibodies to the insulin receptor. Because of their relatedness to the autoimmune-predisposed New Zealand Black (NZB) and New Zealand White (NZW) inbred strains, we compared NZO to its two related strains for shared hematologic and immunologic characteristics. Comparison of the three strains by serotyping and genotyping methods indicated that NZO shared with NZW the rare (recombinant) H2(z) haplotype at the major histocompatibility complex. Similar to the NZB and NZW strains, spleens from NZO mice contained increased numbers of CD19(+)CD43(+) IgM(+) B-1 B cells, a phenotype associated with natural autoantibody production. NZO mice developed a progressive microcytic anemia that was distinguished from NZB hemolytic anemia by absence of demonstrable antierythrocyte antibodies in the former. Outcross of NZO females with NZB males accelerated development of obesity and diabetes in F1 males. NZO males made B-lymphocyte-deficient by a disrupted immunoglobulin heavy chain gene did not become diabetic. These results suggest that NZO mice should be useful to investigators interested in studying the genetic contributions to autoimmunity made by the related NZW and NZB strains. Further, these results, combined with the pancreatic histopathology contained in the companion manuscript, suggest that B lymphocytes may be important contributors to diabetes pathogenesis in the NZO mouse.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
B lymphocyte deficiency in New Zealand obese mice prevented T2D development, implying that B cells may be vital for T2D pathogenesis.
“Convincing evidence of autoimmunity being involved in T2D pathogenesis was also provided by a study that induced B lymphocyte deficiency in New Zealand obese mice (an obese polygenic mouse model of obesity and T2D), as B lymphocyte deficient mice were found to not develop T2D - this implies that B cells may be vital for T2D pathogenesis.316”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [316]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
Ochsenbein, A. F., Fehr, T. H., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M. (1999) · Science · doi:10.1126/science.286.5447.2156 · Cited by 911 · see citing works
Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.
Hayakawa, K., Hardy, R. R., Honda, M., Herzenberg, L. A., Steinberg, A. D., & Herzenberg, L. A. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2494 · Cited by 637 · see citing works
The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes
Wilkin, T. J. (2001) · Diabetologia · doi:10.1007/s001250100548 · Cited by 623 · see citing works
A practical approach to multicolor flow cytometry for immunophenotyping
Baumgarth, N., & Roederer, M. (2000) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00229-5 · Cited by 451 · see citing works
B1 cells: similarities and differences with other B cell subsets
Martin, F., & Kearney, J. F. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00204-1 · Cited by 395 · see citing works
The genetics of complex autoimmune diseases: non-MHC susceptibility genes
Wanstrat, A., & Wakeland, E. K. (2001) · Nature Immunology · doi:10.1038/ni0901-802 · Cited by 382 · see citing works
Shafrir, E. (1984) · Medical Entomology and Zoology · Cited by 356 · see citing works
Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM
Boes, M. L., Esau, C., Fischer, M. B., Schmidt, T., Carroll, M. C., & Chen, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4776 · Cited by 323 · see citing works
Lam, K., & Rajewsky, K. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.471 · Cited by 223 · see citing works
Development and function of B-1 cells
Hayakawa, K., & Hardy, R. R. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00098-4 · Cited by 221 · see citing works
THE NEW ZEALAND STRAIN OF OBESE MICE
Bielschowsky, M., & Bielschowsky, F. (1956) · Immunology and Cell Biology · doi:10.1038/icb.1956.22 · Cited by 197 · see citing works
Maternal Environment and Genotype Interact to Establish Diabesity in MicePreprint
Reifsnyder, P. C., Churchill, G. A., & Leiter, E. H. (2000) · Genome Research · doi:10.1101/gr.147000 · Cited by 171 · see citing works
Self-citationEvidence of islet cell autoimmunity in elderly patients with type 2 diabetes.
Pietropaolo, M., Barinas-Mitchell, E., Pietropaolo, S. L., Kuller, L. H., & Trucco, M. (2000) · Diabetes · doi:10.2337/diabetes.49.1.32 · Cited by 159 · see citing works
B-1 Cells: unique origins and functions
Stall, A. M., Wells, S. M., & Lam, K. (1996) · Seminars in Immunology · doi:10.1006/smim.1996.0007 · Cited by 126 · see citing works
Leiter, E. H., Reifsnyder, P. C., Flurkey, K., Partke, H.-J., Junger, E., & Herberg, L. (1998) · Diabetes · doi:10.2337/diab.47.8.1287 · Cited by 126 · see citing works
Self-citationGenes and Cellular Requirements for Autoimmune Diabetes Susceptibility in Nonobese Diabetic Mice
SERREZE, D. V., & Leiter, E. H. (2001) · KARGER eBooks · doi:10.1159/000060527 · Cited by 117 · see citing works
Self-citationGeneration, expansion, migration and activation of mouse B1 cells
Fagarasan, S., Watanabe, N., & Honjo, T. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.00604.x · Cited by 97 · see citing works
The NZB mouse as a model for chronic lymphocytic leukemia.
Phillips, J. A., Mehta, K., Fernandez, C., & Raveche, E. S. (1992) · PubMed · Cited by 84 · see citing works
SERREZE, D. V., Leiter, E. H., Kuff, E. L., Jardieu, P. M., & Ishizaka, K. (1988) · Diabetes · doi:10.2337/diab.37.3.351 · Cited by 71 · see citing works
Self-citationHEMAGGLUTINATION AND CYTOTOXIC STUDIES OF H-2
Snell, G. D., Démant, P., & Cherry, M. (1971) · Transplantation · doi:10.1097/00007890-197103000-00002 · Cited by 68 · see citing works
Gorus, F., Weets, I., & PIPELEERS, D. G. (2002) · Diabetologia · doi:10.1007/s00125-001-0724-2 · Cited by 57 · see citing works
Plum, L., Kluge, R., Giesen, K., Altmüller, J., Ortlepp, J. R., & Joost, H. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1590 · Cited by 54 · see citing works
Diabetes is Associated with Autoimmunity in the New Zealand Obese (NZO) Mouse
Melez, K. A., Harrison, L. C., Gilliam, J. N., & Steinberg, A. D. (1980) · Diabetes · doi:10.2337/diacare.20.10.835 · Cited by 48 · see citing works
Fujimura, T. (1998) · International Immunology · doi:10.1093/intimm/10.10.1467 · Cited by 46 · see citing works
Wang, Z., Shi, J., Zhou, Y., & Ruan, C. (2001) · International Journal of Hematology · doi:10.1007/bf02981936 · Cited by 45 · see citing works
Analysis of MHC Class II Genes in the Susceptibility to Lupus in New Zealand Mice
Rozzo, S. J., Vyse, T. J., David, C. S., Palmer, E., Izui, S., & Kotzin, B. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2623 · Cited by 38 · see citing works
Molecular pathology of type 1 diabetes.
Campbell, I. L., & Harrison, L. C. (1990) · PubMed · Cited by 38 · see citing works
Hamano, Y., Hirose, S., Ida, A., Abe, M., Zhang, D., Kodera, S., Jiang, Y., Shirai, J., Miura, Y., Nishimura, H., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3772 · Cited by 37 · see citing works
Flow cytometry of DNA content using oxazine 750 or related laser dyes with 633 nm excitation
Shapiro, H. M., & Stephens, S. (1986) · Cytometry · doi:10.1002/cyto.990070118 · Cited by 33 · see citing works
Shiroishi, T., Sagai, T., & Moriwaki, K. (1981) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1981.tb00141.x · Cited by 33 · see citing works
Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice.
Leiter, E. H., Procházka, M., & Shultz, L. D. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3224 · Cited by 32 · see citing works
Self-citationThe Diabetes-Prone NZO/Hl Strain. II. Pancreatic Immunopathology
Junger, E., Herberg, L., Jeruschke, K., & Leiter, E. H. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000018917.69993.ba · Cited by 31 · see citing works
Self-citationGenetic regulation of erythrocyte autoantibody production in New Zealand black mice
Ozaki, S., Honda, H., Maruyama, N., Hirose, S., Hamaoki, M., Sato, H., & Shirai, T. (1983) · Immunogenetics · doi:10.1007/bf00952963 · Cited by 29 · see citing works
A possible mechanism for insulin resistance and hyperglycaemia in NZO mice
Harrison, L. C., & Itin, A. (1979) · Nature · doi:10.1038/279334a0 · Cited by 25 · see citing works
Differential and genetically separable associations of leptin with obesity-related traits
Thorburn, A. W., Holdsworth, A., Proietto, J., & Morahan, G. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801213 · Cited by 22 · see citing works
Mechanisms and Genetics of Autoimmunitya
Theofilopoulos, A. N., & Kono, D. H. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10932.x · Cited by 22 · see citing works
T-Lymphopenia and T-Cell Imbalance in Diabetic db/db Mice
Boillot, D., Assan, R., Dardenne, M., Debray-Sachs, M., & Bach, J. (1986) · Diabetes · doi:10.2337/diab.35.2.198 · Cited by 14 · see citing works
Pancreatic cellular infiltrates in autoimmune-prone New Zealand Black mice
Seemayer, T. A., & Colle, E. (1984) · Diabetologia · doi:10.1007/bf00283656 · Cited by 11 · see citing works
Virus-induced Diabetes in Autoimmune New Zealand Mice
Yoon, J., Melez, K. A., Smathers, P. A., Archer, J. A., & Steinberg, A. D. (1983) · Diabetes · doi:10.2337/diab.32.8.755 · Cited by 6 · see citing works
B Cells are Selectively Associated with Thymic Cortical but not Medullary Pathology in NZB Mice
Taguchi, N., Hashimoto, Y. K., Hsu, T. C., Ansari, A. A., Shultz, L., Dorshkind, K. A., Ikehara, S., Naiki, M., & Gershwin, M. E. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2001.0515 · Cited by 5 · see citing works
Melez, K. A., Attallah, A. M., Harrison, E. T., & Raveche, E. S. (1985) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(85)90044-3 · Cited by 5 · see citing works
Rice, E. W. (1976) · American Journal of Clinical Pathology · doi:10.1093/ajcp/66.1.122 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Snell GD (1976). Histocompatibility. New York: Academic Press, 401.
Cited by
Sorted by citations
The use of animal models in diabetes research
King, A. J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01911.x · Cited by 1,303 · see citing works
DeFuria, J., Belkina, A. C., Jagannathan-Bogdan, M., Snyder-Cappione, J., Carr, J. D., Nersesova, Y. R., Markham, D., Strissel, K. J., Watkins, A. A., Zhu, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215840110 · Cited by 521 · see citing works
Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441 · see citing works
Pathogenic Roles of B Cells in Human Autoimmunity
Martin, F., & Chan, A. C. (2004) · Immunity · doi:10.1016/s1074-7613(04)00112-8 · Cited by 223 · see citing works
The Genetic Landscape of Type 2 Diabetes in Mice
Clee, S. M., & Attie, A. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0035 · Cited by 221 · see citing works
Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus
Zang, L., Shimada, Y., & Nishimura, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-01432-w · Cited by 159 · see citing works
Mohammad, M. K., Morran, M. P., Slotterbeck, B. D., Leaman, D. W., Sun, Y., von Grafenstein, H., Hong, S., & McInerney, M. F. (2006) · International Immunology · doi:10.1093/intimm/dxl045 · Cited by 125 · see citing works
Type 2 Diabetes: How Much of an Autoimmune Disease?
de Candia, P., Prattichizzo, F., Garavelli, S., Rosa, V. D., Galgani, M., Rella, F. D., Spagnuolo, M. I., Colamatteo, A., Fusco, C., Micillo, T., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00451 · Cited by 118 · see citing works
Autoimmune Aspects of Type 2 Diabetes Mellitus - A Mini-Review
Itariu, B. K., & Stulnig, T. M. (2014) · Gerontology · doi:10.1159/000356747 · Cited by 107 · see citing works
Revisiting Experimental Models of Diabetic Nephropathy
Giralt-López, A., den Bosch, M. M. V., Vergara, A., García-Carro, C., Serón, D., Jacobs-Cachá, C., & Soler, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103587 · Cited by 103 · see citing works
Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes
Leiter, E. H., & Reifsnyder, P. C. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s4 · Cited by 99 · see citing works
Self-citationTh17 and Treg lymphocytes in obesity and Type 2 diabetic patients
Wang, M., Chen, F., Wang, J., Zeng, Z., Yang, Q., & Shao, S. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.09.005 · Cited by 99 · see citing works
Zhao, Y. L., Jiang, Z., Zhao, T., Ye, M., Hu, C., Zhou, H., Yin, Z., Chen, Y., Zhang, Y., Wang, S., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-160 · Cited by 84 · see citing works
Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity
Weinstock, A., Silva, H. M., Moore, K. J., Schmidt, A. M., & Fisher, E. A. A. (2020) · Circulation Research · doi:10.1161/circresaha.120.316203 · Cited by 67 · see citing works
Zhang, Y. P., Song, C. Y., Yuan, Y., Eber, A. E., Rodriguez, Y. F., Levitt, R. C., Takács, P., Yang, Z., Goldberg, R. B., & Candiotti, K. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.05.003 · Cited by 57 · see citing works
The outliers become a stampede as immunometabolism reaches a tipping point
Nikolajczyk, B. S., Jagannathan‐Bogdan, M., & Denis, G. V. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01142.x · Cited by 54 · see citing works
Kluge, R., Scherneck, S., Schürmann, A., & Joost, H. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7_5 · Cited by 48 · see citing works
Wu, K.-C., Pan, H., Yin, H., Chen, M., Lu, S., & Lin, C. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.014 · Cited by 33 · see citing works
Koza, R. A., Flurkey, K., Graunke, D. M., Braun, C. J., Pan, H., Reifsnyder, P. C., Kozak, L. P., & Leiter, E. H. (2004) · Metabolism · doi:10.1016/j.metabol.2003.12.024 · Cited by 33 · see citing works
Self-citationThe Diabetes-Prone NZO/Hl Strain. II. Pancreatic Immunopathology
Junger, E., Herberg, L., Jeruschke, K., & Leiter, E. H. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000018917.69993.ba · Cited by 31 · see citing works
Self-citationAnimal Models of Type 1 and Type 2 Diabetes Mellitus
King, A., & Austin, A. L. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00010-3 · Cited by 32 · see citing works
The Bidirectional Relationship between Metabolism and Immune Responses
Raval, F. (2013) · Discoveries · doi:10.15190/d.2013.6 · Cited by 25 · see citing works
Animal Models of Kidney Disease
Mohammed‐Ali, Z., Carlisle, R. E., Nademi, S., & Dickhout, J. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00016-4 · Cited by 27 · see citing works
Current status and patent prospective of animal models in diabetic research
Singh, G., Dhuria, R. S., Kaur, A., Kaur, R., & Kaur, T. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.157847 · Cited by 24 · see citing works
Koufakis, T., Dimitriadis, G., Metallidis, S., Zebekakis, P. E., & Kotsa, K. (2021) · Obesity Reviews · doi:10.1111/obr.13231 · Cited by 18 · see citing works
Kim, L. J., Shin, M., Pho, H., Otvos, L. J., Tufik, S., Andersen, M. L., Pham, L. V., & Polotsky, V. Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.688375 · Cited by 15 · see citing works
Goonoo, N., & Bhaw‐Luximon, A. (2017) · Nanotechnology Reviews · doi:10.1515/ntrev-2017-0162 · Cited by 11 · see citing works
Hansen, H. H., Hansen, G., Secher, T., Feigh, M., Veidal, S. S., Fosgerau, K., Jelsing, J., & Vrang, N. (2019) · Springer eBooks · doi:10.1007/978-3-030-11748-1_14 · Cited by 9 · see citing works
Erkens, R., Duse, D. A., Brum, A., Chadt, A., Becher, S., Siragusa, M., Quast, C., Muessig, J. M., Roden, M., Cortese-Krott, M. M., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16483 · Cited by 7 · see citing works
Screening of Natural Antidiabetic Agents
Egbuna, C., Palai, S., Ebhohimen, I. E., Mtewa, A. G., Ifemeje, J. C., Tupas, G. D., & Kryeziu, T. L. (2019) · Springer eBooks · doi:10.1007/978-981-13-6920-9_11 · Cited by 7 · see citing works
Anti-Diabetic Effect of Fruits on Different Animal Model System
Papitha, R., Renu, K., Selvaraj, C. I., & Gopalakrishnan, A. V. (2018) · Springer eBooks · doi:10.1007/978-3-319-74210-6_9 · Cited by 6 · see citing works
McInerney, M. F., Najjar, S. M., Brickley, D. R., Lutzke, M. L., Abou-Rjaily, G. A., Reifsnyder, P. C., Haskell, B. D., Flurkey, K., Zhang, Y.-J., Pietropaolo, S. L., et al. (2004) · Journal of Diabetes Research · doi:10.1080/15438600490478029 · Cited by 6 · see citing works
Self-citationCandidate Gene Expression in Adult Zebrafish Models of Type 2 Diabetes Mellitus
Shezi, M. N., Snyman, C., & Niesler, C. U. (2024) · Zebrafish · doi:10.1089/zeb.2024.0154 · Cited by 5 · see citing works
Autoimmune diseases and metabolic disorders: Molecular connections and potential therapeutic targets
Uddin, M. J., Tran, D. K., Hannan, M. A., Hasan-Al-Faruque, Rahman, M. A., Moni, A., Lam, N. T., Ngọc, V. T. N., & Chu, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85415-3.00018-0 · Cited by 2 · see citing works
Gandhi, T., Patel, A., & Purohit, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90583-1.00034-9 · Cited by 2 · see citing works
Development of Improved Animal Models for the Study of Diabetes
Ciobotaru, E. (2013) · InTech eBooks · doi:10.5772/49985 · Cited by 1 · see citing works
Metz, C. N., Hudson, L., & Pavlov, V. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_11-1 · Cited by 1 · see citing works
Cord Blood Stem Cells for Clinical Use
Zhao, Y. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407785-0.00012-8 · Cited by 1 · see citing works
Metz, C. N., Hudson, L., & Pavlov, V. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-18741-9_11 · Cited by 1 · see citing works
Dunford, E. C. (2016) · YorkSpace (York University) · Cited by 1 · see citing works
Mouse Models to Study Obesity Effects on Hematologic Malignancies
Tucci, J., & Mittelman, S. D. (2015) · Energy balance and cancer · doi:10.1007/978-3-319-16733-6_5
Yang, S., Zhang, G., Liu, W., Wang, Z., Zhang, J., Yang, D., Chen, Y. E., Sun, H., & Li, Y. (2017) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2017.05.001
Erkens, R., Duse, D. A., Brum, A., Chadt, A., Becher, S., Siragusa, M., Quast, C., Muessig, J. M., Roden, M., Cortese-Krott, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.25.538211
Genetic Diversity Influences Response and Outcome to Blast Traumatic Brain Injury in a Murine Model
Georges, A. P., Browne, K. D., Augustin, D. V., Bello, A. H., Cullen, D. K., & Meaney, D. F. (2026) · Neurotrauma Reports · doi:10.1177/2689288x251411057
Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping
Lai, S., Keller, M. P., Zhang, J., Fang, Z., Xie, Y., Weng, C., Zhang, S., Zhang, S., Gao, P., Ke, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71726-z
Animal Models of Neurodegenerative Diseases
Tuma, J., Cendelín, J., & Kapl, S. (2026) · Contemporary clinical neuroscience · doi:10.1007/978-3-032-18296-8_4
Sawaed, W., Dallasheh, A., Eliyahu, S., Aburomi, N., Sivan, A., Kurtz, M., Assa, M., Malka, A., Perez, S., & Piran, R. (2026) · MedComm · doi:10.1002/mco2.70813
- Authors
- Haskell, B. D., Flurkey, K., Duffy, T. M., Sargent, E. E., & Leiter, E. H.
- Affiliations
- Jackson Laboratory (US)
- Corresponding author
- Leiter, Edward H
- Venue
- Laboratory Investigation
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 82
- Issue
- 7
- Pages
- 833-842
- ISSN
- 0023-6837 (ISSN-L)
- OpenAlex
- W1990422085
- Cited by
- 47
- References
- 42
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institutes of Health (5r01dk056853-02)
- National Cancer Institute (#CA34196, P30CA034196)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 56853)
- National Center for Research Resources (RR08911, P01-RR08911, P01RR008911)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- type 2 diabetes, polygenic obesity, autoimmunity, major histocompatibility complex, B-1 cells, natural autoantibodies, microcytic anemia, immunoglobulin heavy chain genes, B cells, diabetes pathogenesis, insulin receptor antibodies
- MeSH terms
- Animals, B-Lymphocytes, Crosses, Genetic, Diabetes Mellitus, Diabetes Mellitus, Type 1, Disease Models, Animal, Genotype, Male, Mice, Mutant Strains, Obesity, Serotyping, Spleen, T-Lymphocytes, B-Lymphocyte Subsets, T-Lymphocyte Subsets, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
