Cited by 31Adipose Tissue and MetabolismDiabetes, Cardiovascular Risks, and LipoproteinsMuscle metabolism and nutrition

Assessment of intramuscular triglycerides: contribution to metabolic abnormalities

Dubé, John, Goodpaster, Bret H·2006·Current Opinion in Clinical Nutrition & Metabolic Care

Abstract

PURPOSE OF REVIEW: The purpose of this review is to highlight recent methodological advances that have helped us to understand the role of intramuscular triglycerides in human health as well as prevention and treatment of disease. In addition to both invasive (muscle biopsy) and noninvasive methods, techniques to assess other lipids within muscle will be reviewed. RECENT FINDINGS: In addition to intramuscular triglycerides, other lipids contained within skeletal muscle such as diacylglycerol and ceramides may have an important role in human metabolic disease. Both ex-vivo and in-vivo methods to obtain serial measurements of these muscle lipids as a result of experimental perturbation have recently provided unique insight into their respective roles in human metabolism. SUMMARY: Triglyceride accumulation within skeletal muscle has received considerable interest due to its potential role in insulin resistance and fatty acid metabolism of obesity, aging and type 2 diabetes. Observations that triglycerides themselves may be used as a fuel source for exercising muscle, and thus may not be detrimental in all circumstances, has in part prompted the development and implementation of analytical methods to quantify the fatty acid composition of muscle triglycerides as well as other lipid species within muscle, e.g. diacylglycerol and ceramides. In addition, noninvasive computed tomography, magnetic resonance spectroscopy and magnetic resonance imaging methods have been applied to examine the serial effects of intervention on muscle triglycerides.

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Crossref · 10.1097/01.mco.0000241664.38385.12

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Authors
Dubé, J., & Goodpaster, B. H.
Affiliations
University of Pittsburgh (US)
Corresponding author
Goodpaster, Bret H
Venue
Current Opinion in Clinical Nutrition & Metabolic Care
Published
2006-09
Volume
9
Issue
5
Pages
553-559
ISSN
1363-1950 (ISSN-L)
OpenAlex
W1977286424
Cited by
31
References
43
Citations by year
2021: 1 · 2020: 2 · 2019: 2 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 3
FWCI
0.19
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
intramuscular triglycerides, skeletal muscle lipids, diacylglycerol, ceramide, insulin resistance, type 2 diabetes, obesity, aging, magnetic resonance spectroscopy, computed tomography, muscle biopsy, metabolic disorders
MeSH terms
Body Composition, Fatty Acids, Humans, Immunohistochemistry, Insulin Resistance, Microscopy, Electron, Magnetic Resonance Spectroscopy, Obesity, Triglycerides, Absorptiometry, Photon, Muscle, Skeletal

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