Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue Microarray

Tissue microarrays for high-throughput molecular profiling of tumor specimens

Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101

Cancer Statistics, 2001

Greenlee, R. T., Hill-Harmon, M. B., Murray, T., & Thun, M. J. (2001) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.51.1.15 · Cited by 3,281

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337

Delineation of prognostic biomarkers in prostate cancer

Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R. B., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., & Chinnaiyan, A. M. (2001) · Nature · doi:10.1038/35090585 · Cited by 1,675

Is a p53-Regulated Inhibitor of G2/M Progression

Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251

Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions

Hruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126

Specific protection against breast cancers by cyclin D1 ablation

Yu, Q., Geng, Y., & Sicinski, P. (2001) · Nature · doi:10.1038/35082500 · Cited by 934

Progression model for pancreatic cancer.

Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872

Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers.

Chang, K., & Pastan, I. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.136 · Cited by 747

Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer

Reiter, R. E., Gu, Z., Watabe, T., THOMAS, G. V., Szigeti, K., Davis, E., Wahl, M. I., Nisitani, S., Yamashiro, J. M., Beau, M. M. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1735 · Cited by 675

Mesothelin is a specific biomarker of invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for diagnosis and therapy

Alvarez, H., Rojas, P. L., Yong, K., Ding, H. Y., Xu, G., Prasad, P. N., Wang, J. C. Y., Canto, M. I., Eshleman, J. R., Montgomery, E. A., et al. (2008) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2008.06.006 · Cited by 22

Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts during rat liver development

Hayashi, Y., Toda, K., Saibara, T., Okamoto, S., Osanai, M., Enzan, H., & Lee, G. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0683-8 · Cited by 22

Extensive biliary intraepithelial neoplasia (BilIN) and multifocal early intrahepatic cholangiocarcinoma in non-biliary cirrhosis

Rougemont, A., Genevay, M., McKee, T., Gremaud, M., Mentha, G., & Rubbia‐Brandt, L. (2010) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-010-0899-3 · Cited by 22

Evaluation of pancreatic intraepithelial neoplasia and mucin expression in normal pancreata

Matsuyama, M., Kondo, F., Ishihara, T., Yamaguchi, T., Ito, R., Tsuyuguchi, T., Tawada, K., & Yokosuka, O. (2011) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1007/s00534-011-0401-x · Cited by 21

Familial intraductal papillary mucinous neoplasms of the pancreas

Rebours, V., Couvelard, A., Peyroux, J.-L., Sauvanet, A., Hammel, P. R., Ruszniewski, P. B., & Lévy, P. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.07.003 · Cited by 21

Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer

Yamasaki, S., Miura, Y., Davydova, J., Vickers, S. M., & Yamamoto, M. (2012) · International Journal of Cancer · doi:10.1002/ijc.27983 · Cited by 21

Human pancreatic cancer progression: an anarchy among CCN-siblings

Banerjee, S. K., Maity, G., Haque, I., Ghosh, A., Sarkar, S., Gupta, V. G., Campbell, D. R., Hoff, D. D. V., & Banerjee, S. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0343-9 · Cited by 21

Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia–3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias

Lisovsky, M., Dresser, K., Woda, B. A., & Mino-Kenudson, M. A. (2010) · Human Pathology · doi:10.1016/j.humpath.2009.12.004 · Cited by 20

p16, p21, and p53 proteins play an important role in development of pancreatic intraepithelial neoplastic

Dorf, J., Zaręba, K. P., Guzińska-Ustymowicz, K., Kędra, B., Kemonä, A., & Pryczynicz, A. (2018) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-018-1751-z · Cited by 20

Pancreatic Tumorigenesis: Precursors, Genetic Risk Factors and Screening

Badheeb, M. A., Abdelrahim, A., Esmail, A., Umoru, G., Abboud, K., Al-Najjar, E., Rasheed, G. O., Alkhulaifawi, M., Abudayyeh, A., & Abdelrahim, M. (2022) · Current Oncology · doi:10.3390/curroncol29110686 · Cited by 20

Co-occurring IPMN and pancreatic cancer: the same or different? An overview from histology to molecular pathology

Omori, Y., Furukawa, T., Scarpa, A., & Luchini, C. (2023) · Journal of Clinical Pathology · doi:10.1136/jcp-2023-209012 · Cited by 19

Pathology of Pancreatic Cancer Precursor Lesions

Noë, M., & Brosens, L. A. A. (2016) · Surgical pathology clinics · doi:10.1016/j.path.2016.05.004 · Cited by 19

Pancreatic Cancer Screening

Das, K. K., & Early, D. S. (2017) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-017-0149-8 · Cited by 19

Biomarker Validation: In Situ Analysis of Protein Expression Using Semiquantitative Immunohistochemistry-Based Techniques

Sullivan, C. A. W., & Chung, G. G. (2008) · Clinical Colorectal Cancer · doi:10.3816/ccc.2008.n.022 · Cited by 19

Molecular Characterization of Pancreatic Ductal Adenocarcinoma Using a Next-Generation Sequencing Custom-Designed Multigene Panel

Malvi, D., Vasuri, F., Maloberti, T., Sanza, V., Leo, A. D., Fornelli, A., Masetti, M., Benini, C., Lombardi, R., Offi, M. F., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12051058 · Cited by 18

Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells

Zhang, Y., Zhang, X., Miao, X., Yuan, Y.-Y., Gao, J., Li, X., Liu, Y., & Tan, P. (2019) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2019.1585820 · Cited by 18

Tissue Microarrays: Construction and Use

Remotti, H. E. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-287-2_2 · Cited by 18

Immunohistology of the Pancreas, Biliary Tract, and Liver

Baştürk, O., Farris, A. B., & Adsay, V. N. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5766-6.00019-4 · Cited by 18

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Ma, J., Fu, S., Tan, J., Han, Y., Chen, Y., Deng, X., Shen, H., Zeng, S., Peng, Y., & Cai, C. (2025) · Advanced Science · doi:10.1002/advs.202502714 · Cited by 17

Screening for Pancreatic Cancer

Wada, K., Takaori, K., & Traverso, L. W. (2015) · Surgical Clinics of North America · doi:10.1016/j.suc.2015.05.010 · Cited by 17

DNA Methylation Mediates EMT Gene Expression in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Urbanova, M., Buociková, V., Trnkova, L., Strapcova, S., Kajabová, V. H., Barreto, E., Novisedláková, M., Tomáš, M., Dubovan, P., Earl, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042117 · Cited by 17

Presence of pancreatic intraepithelial neoplasia‐3 in a background of chronic pancreatitis in pancreatic cancer patients

Hwang, I. K., Kim, H., Lee, Y. S., Kim, J., Cho, J. Y., Yoon, Y., Han, H., & Hwang, J. (2015) · Cancer Science · doi:10.1111/cas.12744 · Cited by 17

Assessing the role of the EGF receptor in the development and progression of pancreatic cancer

Moore, M. J., Cook, N., & Frese, K. K. (2014) · Gastrointestinal Cancer Targets and Therapy · doi:10.2147/gictt.s58925 · Cited by 17

The secret origins and surprising fates of pancreas tumors

Bailey, J. M., DelGiorno, K. E., & Crawford, H. C. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu056 · Cited by 17

K-ras and Dpc4 mutations in chronic pancreatitis: case series.

Hadžija, M. P., Korolija, M., Razumović, J. J., Pavković, P., Hadžija, M., & Kapitanović, S. (2007) · PubMed Central · Cited by 17

Molecular Alterations in Exocrine Neoplasms of the Pancreas

Ranganathan, P., Gowda, H., & Pandey, A. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.3.405 · Cited by 16

Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes

Alzhrani, R. M., Alsaab, H. O., Vanamala, K., Bhise, K., Tatiparti, K., Barari, A., Sau, S., & Iyer, A. K. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000262 · Cited by 16

Comparative efficacy and safety of PSCA CAR-engineered Vδ1 γδ T cells for immunotherapy of pancreatic cancer

Li, Z., Liu, N., Shah, Z., Jin, L., Tian, L., Sun, X., Zhang, J., Li, Z., Caligiuri, M. A., & Yu, J. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-011890 · Cited by 16

Expression of chosen cell cycle and proliferation markers in pancreatic intraepithelial neoplasia

Dorf, J., Zaręba, K. P., Guzińska-Ustymowicz, K., Kędra, B., Kemonä, A., & Pryczynicz, A. (2018) · Gastroenterology Review · doi:10.5114/pg.2018.75824 · Cited by 15

Actin-Bundling Proteins (Actinin-4 and Fascin-1) are Involved in the Development of Pancreatic Intraepithelial Neoplasia (PanIN)

Misiura, M., Dorf, J., Zaręba, K. P., Kamińska, D., Guzińska-Ustymowicz, K., & Pryczynicz, A. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.11.013 · Cited by 15

Expression and clinical significance of IMP3 in microdissected premalignant and malignant pancreatic lesions

Wang, B., Wang, L., Yang, S., & Liu, Z.-J. (2014) · Clinical & Translational Oncology · doi:10.1007/s12094-014-1216-4 · Cited by 15

Study human pancreatic cancer in mice: How close are they?

Zhang, Y., Chen, L. L., Yang, J., Fleming, J. B., Chiao, P. J., Logsdon, C. D., & Li, M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.11.001 · Cited by 16

Resection of four synchronous invasive ductal carcinomas in the pancreas head and body associated with pancreatic intraepithelial neoplasia: Report of a case

Izumi, S., Nakamura, S., Mano, S., & Suzuka, I. (2009) · Surgery Today · doi:10.1007/s00595-009-3990-0 · Cited by 15

Tissue microarrays: fast-tracking protein expression at the cellular level

Warford, A. (2004) · Expert Review of Proteomics · doi:10.1586/14789450.1.3.283 · Cited by 15

Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysis

Byeon, S., du Toit‐Thompson, T., Gillson, J., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2023) · Cancer Medicine · doi:10.1002/cam4.6407 · Cited by 15

Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges

Pian, L.-L., Song, M.-H., Wang, T., Qi, L., Peng, T.-L., & Xie, K.-P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1401829 · Cited by 15

Genetics of Pancreatic Cancer and Its Implications on Therapy

Tatarian, T., & Winter, J. M. (2016) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.07.014 · Cited by 14

Mesothelin is Commonly Expressed in Pancreatic Adenocarcinoma but Unrelated to Cancer Aggressiveness

Weidemann, S. A., Perez, D. R., Izbicki, J. R., Neipp, M., Mofid, H., Daniels, T., Nahrstedt, U., Jacobsen, F., Bernreuther, C., Simon, R., et al. (2021) · Cancer Investigation · doi:10.1080/07357907.2021.1943747 · Cited by 14

HGF/MET Axis Induces Tumor Secretion of Tenascin-C and Promotes Stromal Rewiring in Pancreatic Cancer

Modica, C., Olivero, M., Zuppini, F., Milan, M., Basilico, C., & Vigna, E. (2021) · Cancers · doi:10.3390/cancers13143519 · Cited by 14

The Wnt pathway is active in a small subset of pancreas cancer cell lines

Pujal, J., Capellá, G., & Real, F. X. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.08.002 · Cited by 14

Genetic alterations in precancerous pancreatic lesions and their clinical implications

Turrini, O., Cano, C. E., Legoffic, A., Delpéro, J., Dagorn, J., & Iovanna, J. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/j.gcb.2009.08.007 · Cited by 13

Extensive cutaneous metastases of pancreatic adenocarcinoma: a case report and review of the literature

Kotsantis, I., Economopoulou, P., Dritsakos, K., Oikonomopoulos, N., Bakogeorgos, M., Rapti, C., & Kentepozidis, N. K. (2016) · Clinical Case Reports · doi:10.1002/ccr3.737 · Cited by 13

Molecular and Genetic Basis of Pancreatic Carcinogenesis

Bernard, V., Fleming, J. B., & Maitra, A. (2016) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2015.11.003 · Cited by 13

Current topics on precursors to pancreatic cancer.

Takaori, K., Hruban, R. H., Maitra, A., & Tanigawa, N. (2006) · PubMed · Cited by 13

Multianalyte Serum Biomarker Panel for Early Detection of Pancreatic Adenocarcinoma

Firpo, M. A., Boucher, K. M., Bleicher, J. M., Khanderao, G. D., Rosati, A., Poruk, K. E., Kamal, S., Marzullo, L., Marco, M. D., Falco, A., et al. (2023) · JCO Clinical Cancer Informatics · doi:10.1200/cci.22.00160 · Cited by 12

mAb Das-1 identifies pancreatic ductal adenocarcinoma and high-grade pancreatic intraepithelial neoplasia with high accuracy

Das, K. K., Brown, J. W., del-Castillo, C. F., Huynh, T. G., Mills, J. C., Matsuda, Y., Das, K. M., & Mino-Kenudson, M. A. (2021) · Human Pathology · doi:10.1016/j.humpath.2021.01.003 · Cited by 12

Recent developments of transgenic and xenograft mouse models of pancreatic cancer for translational research

Schütte, U., Bisht, S., Brossart, P., & Feldmann, G. (2010) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.534453 · Cited by 13

Nanotherapeutics promises for colorectal cancer and pancreatic ductal adenocarcinoma

Bhaw‐Luximon, A., Goonoo, N., & Jhurry, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-42863-7.00006-2 · Cited by 12

Ancillary tests in the diagnosis of liver and pancreatic neoplasms

Misdraji, J., Centeno, B. A., & Pitman, M. B. (2018) · Cancer Cytopathology · doi:10.1002/cncy.22009 · Cited by 12

The Use of Genetically Engineered Mouse Models for Studying the Function of Mutated Driver Genes in Pancreatic Cancer

Weng, C., Lin, Y., & Cheng, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091369 · Cited by 12

Pancreatic Intraepithelial Neoplasia

Hruban, R. H., Brune, K. A., Fukushima, N., & Maitra, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-69252-4_3 · Cited by 12

Early detection markers in Pancreas Cancer

Farrell, J. J., van Rijnsoever, M., & Elsaleh, H. (2005) · Cancer Biomarkers · doi:10.3233/cbm-2005-12-304 · Cited by 12

NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer

Tsesmelis, M., Büttner, U. F. G., Gerstenlauer, M., Manfras, U., Tsesmelis, K., Du, Z., Sperb, N., Weissinger, S. E., Möller, P., Barth, T. F. E., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01989-x · Cited by 11

Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers

Mottini, C., & Cardone, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145023 · Cited by 11

Diagnostic and therapeutic implications of a novel immunohistochemical panel detecting duodenal mucosal invasion by pancreatic ductal adenocarcinoma.

Sopha, S. C., Gopal, P., Merchant, N. B., Revetta, F. L., Gold, D. V., Washington, K., & Shi, C. (2013) · Europe PMC (PubMed Central) · Cited by 11

Tumoral epithelial and stromal expression of SMAD proteins in pancreatic ductal adenocarcinomas

Handra‐Luca, A., Hammel, P. R., Sauvanet, A., Ruszniewski, P. B., & Couvelard, A. (2012) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1007/s00534-012-0518-6 · Cited by 11

Chemoprevention of pancreatic cancer—one step closer

Fendrich, V. (2012) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-012-0916-x · Cited by 11

Mesothelin Expression in Pancreatic Mucinous Cysts

Frank, R., Li, S., Ahmad, N. A., Sepulveda, A. R., & Jhala, N. C. (2014) · American Journal of Clinical Pathology · doi:10.1309/ajcpdttl2i5ecmfg · Cited by 11

Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study

PANKRAS II Study Group, Crous‐Bou, M., Porta, M. S., Morales, E., López‐Jiménez, T., Carrato, A., Puigdomènech, E., & Real, F. X. (2008) · Cancer Causes & Control · doi:10.1007/s10552-008-9267-x · Cited by 11

Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives

Hashimoto, A., & Hashimoto, S. (2024) · Cancers · doi:10.3390/cancers16234094 · Cited by 11

Risk Factors for Pancreatic Ductal Adenocarcinoma Specifically Stimulate Pancreatic Duct Glands in Mice

Bobrowski, A., Spitzner, M., Bethge, S., Müller‐Graf, F., Vollmar, B., & Zechner, D. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.016 · Cited by 10

Increased expression of fascin associated with malignant transformation of sinonasal inverted papilloma

An-liu, W. A. N. G., Liu, H., & Zhang, Y. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200703010-00005 · Cited by 10

The Many Faces of Wnt and Pancreatic Ductal Adenocarcinoma Oncogenesis

Weekes, C. D., & Winn, R. A. (2011) · Cancers · doi:10.3390/cancers3033676 · Cited by 10

Cytoplasmic overexpression with membrane accentuation of stratifin in intrahepatic mass‐forming cholangiocarcinoma after hepatectomy: Correlation with clinicopathologic features and patient survival

Yeh, C., Pang, S., Jung, S., Chen, T.-W., Jan, Y.-Y., & Chen, M. (2010) · Journal of Surgical Oncology · doi:10.1002/jso.21604 · Cited by 10

Pancreatic Cancer Genomes: Toward Molecular Subtyping and Novel Approaches to Diagnosis and Therapy

Wood, L. D. (2013) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0043-6 · Cited by 10

Lifetime history of alcohol consumption and K‐ras mutations in pancreatic ductal adenocarcinoma

Crous‐Bou, M., Porta, M. S., López‐Jiménez, T., Jariod, M., Malats, N., Morales, E., Guarner, L., Rifà, J., Carrato, A., Real, F. X., et al. (2009) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20483 · Cited by 10

AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors

Min, J., Schweizer, L., Zonderland, G., Selvanesan, B. C., Thomsen, J. H., Oldenburg, L., Bae, S.-W., Kim, B., Hernandez, S. D., Jez, G., et al. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-1119 · Cited by 9

Epigenetic dysregulation in pancreatic cancer: emerging biomarkers and clinical applications

Sultana, H., Solomon, A. D., Wani, A. K., & Shukla, S. K. (2025) · Frontiers in Epigenetics and Epigenomics · doi:10.3389/freae.2025.1723159 · Cited by 9

SMAD4 protein expression and cell proliferation in colorectal adenocarcinomas

Handra‐Luca, A., Olschwang, S., & Fléjou, J. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1152-4 · Cited by 9

Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin

Komine, R., Kojima, M., Ishii, G., Kudo, M., Sugimoto, M., Kobayashi, S., Takahashi, S., Konishi, M., Kobayashi, T., Akimoto, T., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.3809 · Cited by 9

Where and When Does Pancreatic Carcinoma Start?

L�ttges, J., Hahn, S. A., & Kl�ppel, G. (2004) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-004-1028-3 · Cited by 9

Tissue Microarrays for Testing Molecular Biomarkers of Cervical Intraepithelial Neoplasia

Schneider, V. (2006) · Acta Cytologica · doi:10.1159/000325919 · Cited by 9

Molecular cytogenetic evidence for multistep tumorigenesis: Implications for risk assessment and early detection

Sen, S., & Hopwood, V. L. (2011) · Cancer Biomarkers · doi:10.3233/cbm-2011-0171 · Cited by 9

p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer

Miller, P., Akama‐Garren, E. H., Owen, R. P., Demetriou, C., Carroll, T. M., Slee, E. A., Moussawi, K. A., Ellis, M., Goldin, R. D., O’Neill, E. E., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01168-3 · Cited by 8

Well-differentiated pancreatic ductal adenocarcinomas measuring ≤1 cm exhibit early features of tumor progression: a report of five lesions and a comparative study with advanced lesions

Izumi, S., Nakamura, S., Mano, S., & ONODA, Y. (2013) · Surgery Today · doi:10.1007/s00595-013-0804-1 · Cited by 7

A Minute Pancreatic Ductal Adenocarcinoma with Lipomatous Pseudohypertrophy of the Pancreas

Izumi, S. (2011) · PubMed · doi:10.6092/1590-8577/448 · Cited by 7

The Molecular Pathology of Precursor Lesions of Pancreatic Cancer

Singhi, A. D., & Maitra, A. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_5 · Cited by 7

Differential MicroRNA Expression Profiles as Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

Zhu, Y., Wang, J., Wang, F., Yan, Z., Liu, G., Ma, Y., Zhu, W., Li, Y., Xie, L., Bazhin, A. V., et al. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919050122 · Cited by 8

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules

Hu, J., Jiang, J., Xu, B., Li, Y., Wang, B., He, S., Ren, X., Shi, B., Zhang, X., Zheng, H., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117590 · Cited by 6

Well Differentiation and Intact Smad4 Expression Are Specific Features of Groove Pancreatic Ductal Adenocarcinomas

Izumi, S., Nakamura, S., Mano, S., & Akaki, S. (2014) · Pancreas · doi:10.1097/mpa.0000000000000260 · Cited by 6

Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice

Cáceres, M., Quesada, R., Iglesias, M., Real, F. X., Villamonte, M., de Villarreal, J. M., Pérez, M., Andaluz, A., Moll, X., BERJANO, E. J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74947-4 · Cited by 6

Status of the DPC4 tumor suppressor gene in sporadic colon adenocarcinoma of Croatian patients: identification of a novel somatic mutation

Hadžija, M. P., Radošević, S., Kovačević, D., Lukač, J., Hadžija, M., Spaventi, R., Pavelić, K., & Kapitanović, S. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.12.018 · Cited by 6

Novel perspectives on MSLN-targeted cancer therapy: from molecular mechanisms to clinical translation

Wu, Z., Fu, X., Feng, Y., Zeng, R., Qin, H., & Yao, K. (2025) · Cancer Biology & Therapy · doi:10.1080/15384047.2025.2603105 · Cited by 5

Tumor-associated neutrophils in pancreatic ductal adenocarcinoma: mechanisms and therapeutic targeting

Wu, X., Zhu, W., Chen, W., & Ruan, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1806714 · Cited by 5

Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization

Griffith, B. D., Kadiyala, P., McGue, J. J., Sun, L., Kumar, A., Espinoza, C. E., Donahue, K. L., Iyer, M. K., Speyer, C. B., Nelson, S., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0377 · Cited by 5

Inflammation and de-differentiation in pancreatic carcinogenesis

Seimiya, T., Otsuka, M., Iwata, T., Tanaka, E., Suzuki, T., Sekiba, K., Yamagami, M., Ishibashi, R., & Koike, K. (2018) · World Journal of Clinical Cases · doi:10.12998/wjcc.v6.i15.882 · Cited by 5

Molecular diagnostics of hepatobiliary and pancreatic neoplasias

Longerich, T., Stenzinger, A., & Schirmacher, P. (2024) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-024-03744-5 · Cited by 5

Individuals at high-risk for pancreatic cancer development: Management options and the role of surgery

Sakorafas, G. H., Tsiotos, G. G., Korkolis, D. P., & Smyrniotis, V. E. (2012) · Surgical Oncology · doi:10.1016/j.suronc.2011.12.006 · Cited by 5

Robot-Guided Atomic Force Microscopy for Mechano-Visual Phenotyping of Cancer Specimens

Chen, W., Brandes, Z. R., Roy, R., Chekmareva, M. A., Pandya, H. J., Desai, J. P., & Foran, D. J. (2015) · Microscopy and Microanalysis · doi:10.1017/s1431927615015007 · Cited by 5

S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer

Srivastava, K., Lines, K. E., Jach, D., & Crnogorac‐Jurcevic, T. (2023) · Oncogene · doi:10.1038/s41388-023-02851-y · Cited by 5

Precursor Lesions of Pancreatic Cancer

Matthaei, H., & Maitra, A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6694-0_19 · Cited by 5

Genetics of hereditary pancreatic carcinoma

Hahn, S. A., & Bartsch, D. K. (2004) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2004.07.006 · Cited by 4

Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasionPreprint

Surcel, A., Schiffhauer, E. S., Thomas, D. G., Zhu, Q., DiNapoli, K. T., Herbig, M., Otto, O., Guck, J. R., Jaffee, E. M., Iglesias, P. A., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/190553 · Cited by 4

Erianin inhibits the proliferation and stemness of pancreatic cancer cells by interacting with MEK1/2

Zhu, Y., Zhou, S., Yang, F.-Q., Zhang, H., Luo, J., Xie, F., Liu, D., Lei, Y., & Deng, L. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117046 · Cited by 3

Pancreatic Cancer

Barreto, S. G. (2018) · Springer eBooks · doi:10.1007/978-981-10-8755-4_16 · Cited by 3

Pancreatic Cancer: Molecular Genetics and Clinical Applications

Sakorafas, G. H., Pappa, I., & Smyrniotis, V. E. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0006057.pub2 · Cited by 3

Genetics of Hereditary Pancreatic Carcinoma

Hahn, S. A., & Bartsch, D. K. (2005) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.12.008 · Cited by 3

Does biology determine survival in pancreatic cancer?

Barreto, S. G. (2019) · Future Oncology · doi:10.2217/fon-2019-0706 · Cited by 3

Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

Zhang, X., Wong, W., Cho, H. S., Yang, D., Dixon, G., Luo, R., Liu, D., Torre, D., Umeda, S., Gonzãlez, F., et al. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.04.012 · Cited by 2

Harnessing the potential of CAR-NK cell therapy in gastrointestinal cancers: From bench to bedside

Vanan, A. G., Askari, M. R., Bagheri, K., Arghand, M. R., Ghorbaninezhad, F., Tahmasebi, S., Taghizadeh-Anvar, M., Nouri, S., & Safarzadeh, E. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118380 · Cited by 2

Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions

Buchholz, M., Braun, M., Heidenblut, A., Kestler, H. A., Klöppel, G., Schmiegel, W., Hahn, S. A., Lüttges, J., Gress, T. M., & Krebshilfe, F. T. G. P. C. N. O. T. D. (2005) · Oncogene · doi:10.1038/sj.onc.1208804 · Cited by 190

Pancreatic intra-epithelial neoplasia: current clinicopathological and molecular considerations

Andea, A. A., Baştürk, O., & Adsay, V. N. (2005) · Current Diagnostic Pathology · doi:10.1016/j.cdip.2004.11.008 · Cited by 2

MUC4 Expression Increases Progressively in Pancreatic Intraepithelial Neoplasia

Swartz, M. J., Batra, S. K., Varshney, G. C., Hollingsworth, M. A., Yeo, C. J., Cameron, J. L., Wilentz, R. E., Hruban, R. H., & Argani, P. (2002) · American Journal of Clinical Pathology · doi:10.1309/7y7n-m1wm-r0yk-m2va · Cited by 238

Update on pancreatic intraepithelial neoplasia.

Hruban, R. H., Maitra, A., & Goggins, M. (2008) · PubMed Central · Cited by 245

Molecular genetics of pancreatic intraepithelial neoplasia

Feldmann, G., Beaty, R., Hruban, R. H., & Maitra, A. (2007) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-006-1166-5 · Cited by 269