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Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue Microarray
Open accessAbstract
A multistep model for pancreatic adenocarcinoma has been proposed recently. In this model, well-defined, noninvasive ductal lesions are recognized as precursors of invasive cancer and have been classified under the nomenclature of pancreatic intraepithelial neoplasia, or PanIN. Increasing evidence suggests that PanINs represent true neoplasms of the pancreatic ductal epithelium, accumulating histologic and genetic abnormalities in their progression toward invasive cancer. We have constructed a tissue microarray containing 55 PanIN lesions of all histologic grades in order to perform a multicomponent analysis of the pancreatic adenocarcinoma progression model. The protein products of 14 genes encompassing a variety of functional classes, such as tumor suppressor genes (p53, Smad4/Dpc4), oncogenes (beta-catenin), cell cycle antigens (p16, cyclin D1), proliferation antigens (Ki-67, topoisomerase II alpha), and epithelial apomucins (MUC1, MUC2, MUC5), as well as "novel" genes described as differentially up-regulated in invasive pancreas cancer by global microarray expression analysis (mesothelin, prostate stem cell antigen, fascin, and 14-3-3varsigma), were analyzed by immunohistochemistry on the PanIN tissue microarray. Comparison of the results from the current study with previously published data performed on routine histologic sections of PanINs demonstrates that tissue microarrays are a valid platform for molecular analysis not only of invasive cancers but of precursor lesions as well. In addition, this study demonstrates that molecular abnormalities in PanINs are not random but can usually be stratified into "early" changes (e.g., expression of MUC5 and prostate stem antigen, or loss of p16), "intermediate" changes (e.g., expression of cyclin D1), and "late" changes (e.g., expression of p53, proliferation antigens, MUC1, mesothelin, and 14-3-3varsigma, or loss of Smad4/Dpc4). Understanding the molecular pathogenesis of precursor lesions of invasive pancreatic adenocarcinomas using a high-throughput tissue microarray-based approach is a valuable adjunct to designing rational strategies for early detection of this lethal neoplasm.
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“Early molecular profiling coupled with histology allowed for the development of a putative pathological progression model; analogous to the adenoma-carcinoma model in the colon23”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [23]
In the citing paper
“The temporal appearance of these alterations during multistep progression suggests that TP53 and SMAD4 typically occur late, usually in the setting of high-grade lesions or cancer in both PanINs and IPMNs23,51.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [23]
In the citing paper
“For example, approximately 40% of pancreatic ductal adenocarcinomas have mutated TP53 and deleted ARF (Heinmoller, et al., 2000; Hustinx, et al., 2005; Maitra, et al., 2003).”
From The Mdm network and its regulation of p53 activities: a rheostat of cancer risk (2014) · cites this paper as Maitra, et al., 2003
Citations
Cites
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101
Greenlee, R. T., Hill-Harmon, M. B., Murray, T., & Thun, M. J. (2001) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.51.1.15 · Cited by 3,281
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337
Self-citationDelineation of prognostic biomarkers in prostate cancer
Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R. B., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., & Chinnaiyan, A. M. (2001) · Nature · doi:10.1038/35090585 · Cited by 1,675
Is a p53-Regulated Inhibitor of G2/M Progression
Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251
Hruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126
Self-citationSpecific protection against breast cancers by cyclin D1 ablation
Yu, Q., Geng, Y., & Sicinski, P. (2001) · Nature · doi:10.1038/35082500 · Cited by 934
Progression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872
Self-citationChang, K., & Pastan, I. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.136 · Cited by 747
Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer
Reiter, R. E., Gu, Z., Watabe, T., THOMAS, G. V., Szigeti, K., Davis, E., Wahl, M. I., Nisitani, S., Yamashiro, J. M., Beau, M. M. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1735 · Cited by 675
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
Schutte, M. E. M., Hruban, R. H., Geradts, J., Maynard, R. D., Hilgers, W., Rabindran, S. K., Moskaluk, C. A., Hahn, S. A., Schwarte‐Waldhoff, I., Schmiegel, W., et al. (1997) · PubMed · Cited by 659
Self-citationα-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer
Rubin, M. A. (2002) · JAMA · doi:10.1001/jama.287.13.1662 · Cited by 643
Wilentz, R. E., Iacobuzio–Donahue, C. A., Argani, P., McCarthy, D. M., Parsons, J. L., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · PubMed · Cited by 591
Self-citationArgani, P., Iacobuzio–Donahue, C. A., Ryu, B., Rosty, C., Goggins, M., Wilentz, R. E., Murugesan, S. R., Leach, S. D., Jaffee, E. M., Yeo, C. J., et al. (2001) · PubMed · Cited by 574
Self-citationTissue Microarrays for Rapid Linking of Molecular Changes to Clinical Endpoints
Torhorst, J. K. H., Bucher, C., Kononen, J., Haas, P., Zuber, M., Köchli, O. R., Mross, F., Dieterich, H., Moch, H., Mihatsch, M. J., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63075-1 · Cited by 565
14‐3‐3 proteins: key regulators of cell division, signalling and apoptosis
van Hemert, M. J., Steensma, H. Y., & van Heusden, G. P. H. (2001) · BioEssays · doi:10.1002/bies.1134 · Cited by 535
Abraham, S. C., Klimstra, D. S., Wilentz, R. E., Yeo, C. J., Conlon, K. C., Brennan, M. F., Cameron, J. L., Wu, T., & Hruban, R. H. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62563-1 · Cited by 484
Self-citationExploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays
Iacobuzio–Donahue, C. A., Maitra, A., Olsen, M. N., Lowe, A. W., van Heek, N. T., Rosty, C., Kim, W., Sato, N., Parker, A. R., Ashfaq, R., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63911-9 · Cited by 471
Self-citationRedston, M. S., Caldas, C., Seymour, A. B., Hruban, R. H., da Costa, L., Yeo, C. J., & Kern, S. E. (1994) · PubMed · Cited by 451
Self-citationHigh frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer
Ferguson, A. T., Evron, E., Umbricht, C. B., Pandita, T. K., Chan, T. A.-T., Hermeking, H., Marks, J. R., Lambers, A. R., Futreal, P. A., Stampfer, M. R., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100566997 · Cited by 444
Tissue microarrays for gene amplification surveys in many different tumor types.
Schraml, P., Kononen, J., Bubendorf, L., Moch, H., Bissig, H., Nocito, A., Mihatsch, M. J., Kallioniemi, O., & Sauter, G. (1999) · PubMed · Cited by 433
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer
Barton, C., Staddon, S., Hughes, C., Hall, P., O'Sullivan, C., Klöppel, G., Theis, B. A., Russell, R. C. G., Neoptolemos, J. P., & Williamson, R. C. N. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.467 · Cited by 375
Genetic progression in the pancreatic ducts
Hruban, R. H., Wilentz, R. E., & Kern, S. E. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65054-7 · Cited by 373
Self-citationTelomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia
van Heek, N. T., Meeker, A. K., Kern, S. E., Yeo, C. J., Lillemoe, K. D., Cameron, J. L., Offerhaus, G. J. A., Hicks, J. L., Wilentz, R. E., Goggins, M. G., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64432-x · Cited by 363
Self-citationWilentz, R. E., Geradts, J., Maynard, R. D., Offerhaus, G. J. A., Kang, M., Goggins, M., Yeo, C. J., Kern, S. E., & Hruban, R. H. (1998) · PubMed · Cited by 337
Self-citationPancreatic adenocarcinomas frequently show p53 gene mutations.
Scarpa, A., Capelli, P., Mukai, K., Zamboni, G., Oda, T., Iacono, C., & Hirohashi, S. (1993) · PubMed Central · Cited by 332
Argani, P., Rosty, C., Reiter, R. E., Wilentz, R. E., Murugesan, S. R., Leach, S. D., Ryu, B., Skinner, H. G., Goggins, M., Jaffee, E. M., et al. (2001) · PubMed · Cited by 313
Self-citationImmunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas
Wilentz, R. E., Su, G. H., Dai, J. L., Sparks, A. B., Argani, P., Sohn, T. A., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64703-7 · Cited by 304
Self-citationbcl-1, t(11;14), and mantle cell-derived lymphomas [editorial]
Raffeld, M. A., & Jaffe, E. (1991) · Blood · doi:10.1182/blood.v78.2.259.bloodjournal782259 · Cited by 303
Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology
Iacobuzio–Donahue, C. A., Maitra, A., Shen-Ong, G. L. C., van Heek, N. T., Ashfaq, R., Meyer, R., Walter, K., Berg, K. D., Hollingsworth, M. A., Cameron, J. L., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62551-5 · Cited by 294
Self-citationAdsay, N., Merati, K., Andea, A., Sarkar, F., Hruban, R., Wilentz, R. E., Goggins, M., Iocobuzio-Donahue, C. A., Longnecker, D., & Klimstra, D. (2002) · Modern Pathology · doi:10.1097/01.mp.0000028647.98725.8b · Cited by 290
Self-citationGenetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma
Abraham, S. C., Wu, T., Hruban, R. H., Lee, J.-H., Yeo, C. J., Conlon, K. C., Brennan, M. F., Cameron, J. L., & Klimstra, D. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64917-6 · Cited by 275
Self-citationAbraham, S. C., Wu, T., Klimstra, D. S., Finn, L. S., Lee, J.-H., Yeo, C. J., Cameron, J. L., & Hruban, R. H. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63008-8 · Cited by 270
Self-citationLűttges, J., Zamboni, G., Longnecker, D., & Klöppel, G. (2001) · American Journal of Surgical Pathology · doi:10.1097/00000478-200107000-00014 · Cited by 267
Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis.
Gansauge, S., Gansauge, F., Ramadani, M., Stobbe, H., Rau, B., Harada, N., & Beger, H. G. (1997) · PubMed · Cited by 261
Kim, G., Bae, H., Park, H., Kuan, S., Crawley, S., Ho, J. J. L., & Kim, Y. S. (2002) · Gastroenterology · doi:10.1053/gast.2002.36018 · Cited by 252
Luettges, J., Galehdari, H., Bröcker, V., Schwarte‐Waldhoff, I., Henne‐Bruns, D., Klöppel, G., Schmiegel, W., & Hahn, S. A. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64123-5 · Cited by 241
Iwata, N., Yamamoto, H., Sasaki, S., Itoh, F., Suzuki, H., Kikuchi, T., Kaneto, H., Iku, S., Ozeki, I., Karino, Y., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203898 · Cited by 229
Fukushima, N., Sato, N., Ueki, T., Rosty, C., Walter, K., Wilentz, R. E., Yeo, C. J., Hruban, R. H., & Goggins, M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61104-2 · Cited by 225
Self-citationOverexpression of p53 Protein in Adenocarcinoma of the Pancreas
DiGiuseppe, J. A., Hruban, R. H., Goodman, S. N., Polak, M., van den Berg, F. M., Allison, D. C., Cameron, J. L., & Offerhaus, G. J. A. (1994) · American Journal of Clinical Pathology · doi:10.1093/ajcp/101.6.684 · Cited by 217
Self-citationBRCA2 Is Inactivated Late in the Development of Pancreatic Intraepithelial Neoplasia
Goggins, M., Hruban, R. H., & Kern, S. E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65047-x · Cited by 213
Self-citationExpression of mucin antigens in human cancers and its relationship with malignancy potential
Yonezawa, S., & Sato, E. (1997) · Pathology International · doi:10.1111/j.1440-1827.1997.tb03713.x · Cited by 207
Østergaard, M., Rasmussen, H. H., Nielsen, H. V., Vorum, H., Orntoft, T. F., Wolf, H., & Celis, J. E. (1997) · PubMed · Cited by 206
Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.
Pandey, P., Kharbanda, S. M., & Kufe, D. W. (1995) · PubMed · Cited by 189
Ruggeri, B., Zhang, S.-Y., Caamaño, J., DiRado, M., Flynn, S. D., & Klein–Szanto, A. J. (1992) · PubMed · Cited by 172
Genetic Progression and Divergence in Pancreatic Carcinoma
Yamano, M., Fujii, H., Takagaki, T., Kadowaki, N., Watanabe, H., & Shirai, T. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65083-3 · Cited by 160
Cyclooxygenase 2 Expression in Pancreatic Adenocarcinoma and Pancreatic Intraepithelial Neoplasia
Maitra, A., Ashfaq, R., Gunn, C. R., Rahman, A., Yeo, C. J., Sohn, T. A., Cameron, J. L., Hruban, R. H., & Wilentz, R. E. (2002) · American Journal of Clinical Pathology · doi:10.1309/tpg4-ck1c-9v8v-8awc · Cited by 159
Self-citationRyu, B., Jones, J., Blades, N. J., Parmigiani, G., Hollingsworth, M. A., Hruban, R. H., & Kern, S. E. (2002) · PubMed · Cited by 154
Self-citationBouras, T., Southey, M. C., Chang, A. C.-M., Reddel, R. R., Willhite, D., Glynne, R. J., Henderson, M. A., Armes, J. E., & Venter, D. J. (2002) · PubMed · Cited by 153
Grothey, A. F., Hashizume, R., Şahin, A. A., & McCrea, P. D. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1395 · Cited by 148
Biankin, A. V., Kench, J. G., Morey, A. L., Lee, C. S. L., Biankin, S. A., Head, D. R., Hugh, T. B., Henshall, S. M., & Sutherland, R. L. (2001) · PubMed · Cited by 148
Hollingsworth, M. A., Strawhecker, J. M., Caffrey, T. C., & Mack, D. R. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570212 · Cited by 142
Apple, S. K., Hecht, J. R., Lewin, D., Jahromi, S. A., Grody, W. W., & Nieberg, R. K. (1999) · Human Pathology · doi:10.1016/s0046-8177(99)90265-4 · Cited by 133
Maitra, A., Iacobuzio–Donahue, C. A., Rahman, A., Sohn, T. A., Argani, P., Meyer, R., Yeo, C. J., Cameron, J. L., Goggins, M., Kern, S. E., et al. (2002) · American Journal of Clinical Pathology · doi:10.1309/3pam-p5wl-2lv0-r4eg · Cited by 132
Self-citationKlein, W. M., Hruban, R. H., Klein–Szanto, A. J., & Wilentz, R. E. (2002) · Modern Pathology · doi:10.1038/modpathol.3880544 · Cited by 131
Self-citationRyu, B., Jones, J., Hollingsworth, M. A., Hruban, R. H., & Kern, S. E. (2001) · PubMed · Cited by 119
Self-citationGasco, M., Bell, A. K., Heath, V. L., Sullivan, A., Smith, P., Hiller, L., Yuluğ, I. G., Numico, G., Merlano, M. C., Farrell, P. J., et al. (2002) · PubMed · Cited by 118
Kornmann, M., Danenberg, K. D., Arber, N., Beger, H. G., Danenberg, P. V., & Korc, M. (1999) · PubMed · Cited by 113
Hu, W., McCrea, P. D., Deavers, M. T., Kavanagh, J. J., Kudelka, A. P., & Verschraegen, C. F. (2000) · Clinical & Experimental Metastasis · doi:10.1023/a:1026596609969 · Cited by 107
The Renin-Angiotensin System Influences Ocular Endothelial Cell Proliferation in Diabetes
Moravski, C. J., Skinner, S. L., Stubbs, A. J., Sarlos, S., Kelly, D. J., Cooper, M. E., Gilbert, R. E., & Wilkinson‐Berka, J. L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63806-0 · Cited by 95
Increased Cyclin D1 in Human Pancreatic Cancer Is Associated with Decreased Postoperative Survival
Kornmann, M., Ishiwata, T., Itakura, J., Tangvoranuntakul, P., Beger, H. G., & Korc, M. (1998) · Oncology · doi:10.1159/000011879 · Cited by 95
TAP1 down-regulation in primary melanoma lesions: An independent marker of poor prognosis
Kamarashev, J. A., Ferrone, S., Seifert, B., B�ni, R., Nestle, F. O., Burg, G., & Dummer, R. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(20010120)95:1 · Cited by 79
Self-citationInvolvement of the MAP kinase ERK2 in MUC1 mucin signaling
Meerzaman, D. M., Shapiro, P. S., & Kim, K. C. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.1.l86 · Cited by 78
Expression of cyclin D1 and retinoblastoma protein in colorectal cancer
Palmqvist, R., Stenling, R., Öberg, Å., & Landberg, G. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00162-2 · Cited by 77
Pathology of incipient pancreatic cancer
Hruban, R. H., Wilentz, R. E., Goggins, M., Offerhaus, G. J. A., Yeo, C. J., & Kern, S. E. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_4.s9 · Cited by 76
Self-citationAnalysis of β-Catenin Gene Mutations in Pancreatic Tumors
Gerdes, B., Ramaswamy, A., Simon, B., Pietsch, T., Bastian, D., Kersting, M., Moll, R., & Bartsch, D. K. (1999) · Digestion · doi:10.1159/000007704 · Cited by 74
Immunohistochemical analysis of p53 expression in human pancreatic carcinomas.
Zhang, S. Y., Ruggeri, B., Agarwal, P., Sorling, A. F., Obara, T., Ura, H., Namiki, M., & Klein–Szanto, A. J. (1994) · PubMed · Cited by 73
Hassan, R., Lerner, M. R., Benbrook, D. M., Lightfoot, S. A., Brackett, D. J., Wang, Q.-C., & Pastan, I. H. (2002) · PubMed · Cited by 70
Prevention of Pancreatic Cancer and Strategies for Management of Familial Pancreatic Cancer
Hruban, R. H., Canto, M. I., & Yeo, C. J. (2001) · Digestive Diseases · doi:10.1159/000050656 · Cited by 61
Self-citationREVIEW ARTICLE. p53: GUARDIAN OF CELLULAR SENESCENCE
Wynford‐Thomas, D. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199610)180:2 · Cited by 60
Pathology of Cancer of the Pancreas
Wilentz, R. E., & Hruban, R. H. (1998) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30284-9 · Cited by 50
Self-citationPoch, B., Gansauge, F., Schwarz, A., Seufferlein, T. T. W., Schnelldorfer, T., Ramadani, M., Beger, H. G., & Gansauge, S. (2001) · Pancreas · doi:10.1097/00006676-200110000-00009 · Cited by 48
Aberrant Expression of Tumor Suppressor Proteins in the Ewing Family of Tumors
Maitra, A., Roberts, H., Weinberg, A. G., & Geradts, J. (2001) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2001-125-1207-aeotsp · Cited by 48
Self-citationFan, D., Yano, S., Shinohara, H., Solórzano, C. C., Arsdall, M. R. V., Bucana, C. D., Pathak, S., Kruzel, E., Herbst, R. S., Onn, A., et al. (2002) · PubMed · Cited by 42
p53 mutations in sweat gland carcinomas
Biernat, W., Peraud, A., Wozniak, L., & Ohgaki, H. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980504)76:3 · Cited by 40
Regulation of mucin and glycoconjugate expression: from normal epithelium to gastric tumors.
de Bolós, C. (2001) · Frontiers in bioscience · doi:10.2741/bolos · Cited by 37
Clinical contribution of bcl-2, p53 and Ki-67 proteins in pancreatic ductal adenocarcinoma.
Mäkinen, K., Hakala, T., Lipponen, P., ALHAVA, E. M., & Eskelinen, M. J. (1998) · PubMed · Cited by 34
Anton, R. C., Coffey, D. M., Gondo, M., Stephenson, M. A., Brown, R. W., & Cagle, P. T. (2000) · Modern Pathology · doi:10.1038/modpathol.3880215 · Cited by 32
Linder, S., Parrado, C., Falkmer, S., Blåsjö, M., Sundelin, P., & von Rosen, A. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.336 · Cited by 32
Siedow, A., Moshe Szyf, A., Gratchev, A. N., Kobalz, U., Hanski, M. L., Bumke‐Vogt, C., Foss, H., Riecken, E. O., & HANSKI, C. (2002) · Tumor Biology · doi:10.1159/000048689 · Cited by 26
Clifford, S. C., Walsh, S., Hewson, K., Green, E., Brinke, A., Green, P. M., Gianelli, F., Eng, C., & Maher, E. R. (1999) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199909)26:1 · Cited by 22
Regulation of mucin and glycoconjugate expression from normal epithelium to gastric tumors
de Bolós, C. (2001) · Frontiers in bioscience · doi:10.2741/a678 · Cited by 8
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Deer, E. L., González-Hernández, J., Coursen, J. D., Shea, J. E., Ngatia, J., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181c15963 · Cited by 936
Metadata
- Authors
- Maitra, A., Adsay, N. V., Argani, P., Iacobuzio-Donahue, C., De Marzo, A., Cameron, J. L., Yeo, C. J., & Hruban, R. H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Maitra, Anirban
- Venue
- Modern Pathology
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 16
- Issue
- 9
- Pages
- 902-912
- ISSN
- 0893-3952 (ISSN-L)
- OpenAlex
- W1980447806
- Cited by
- 429
- References
- 95
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 11 · 2021: 16 · 2020: 11 · 2019: 14 · 2018: 24 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 22 · 2013: 19 · 2012: 24
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Modern Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P50CA-62924, P50CA062924)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
- Keywords
- pancreatic ductal adenocarcinoma, pancreatic intraepithelial neoplasia, tumor progression, precursor lesions, tissue microarray, molecular pathogenesis, p53, β-catenin, p16, cyclin D1, Ki-67, TOP2A, MUC1, MUC2, mesothelin, prostate stem cell antigen, fascin, 14-3-3 sigma, early detection
- MeSH terms
- Adenocarcinoma, Carcinoma in Situ, DNA, Neoplasm, Humans, Immunohistochemistry, Pancreatic Neoplasms, Precancerous Conditions, Biomarkers, Tumor, Disease Progression
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