Postexposure prophylaxis for HIV in children and adolescents after sexual assault: a prospective observational study in an urban medical center.
Abstract
BACKGROUND: We sought to evaluate the tolerability and feasibility of establishing an HIV postexposure prophylaxis (PEP) program at our hospital using the guidelines for children and adolescents after sexual assault. METHODS: This study was a prospective, nonrandomized observational study conducted from March 1999 until September 2002. Subjects (age <19 years) who presented to a pediatric emergency room within 72 hours of a sexual assault were eligible for enrollment. A 28-day PEP regimen of zidovudine and lamivudine was given. RESULTS: In all, 70 adolescents were evaluated and 33 (31 females and 2 males) were enrolled. The mean age of enrolled subjects was 15 years, 61% were Hispanic, 30% black, and 79% presented to the emergency room within 24 hours of assault. Vaginal exposure was the most common site of penetration (64% [21 of 33]), but 18% (6 of 33) reported anal penetration. Only 9 subjects (27%) took >or=90% of all the medications. All subjects who returned for follow up tested HIV-negative. Adverse events occurred in 48% (16 of 33) of subjects; the most common events were abdominal pain, nausea, or vomiting. CONCLUSION: Poor adherence to medications and visits is a significant problem in PEP programs for sexually assaulted children and adolescents.
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Severe adverse effects are rare from PEP.
“Providers should emphasize that severe adverse effects are rare from PEP (1431–1435).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1433]
Cites
Connor, E. M., SPERLING, R. S., Gelber, R. D., Kiselev, P., Scott, G. B., O’Sullivan, M. J., VanDyke, R., Bey, M., Shearer, W. T., Jacobson, R. L., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311801 · Cited by 3,685 · see citing works
Fleming, D. T., & Wasserheit, J. N. (1999) · Sexually Transmitted Infections · doi:10.1136/sti.75.1.3 · Cited by 2,271 · see citing works
Connor, E. M., SPERLING, R. S., Gelber, R. D., et al. (1995) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199504000-00002 · Cited by 1,821 · see citing works
Guay, L. A., Musoke, P., Fleming, T. R., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)80008-7 · Cited by 1,652 · see citing works
Holtz, T. H., Kachur, S. P., MacArthur, J. R., Roberts, J. M., Barber, A. M., Steketee, R. W., & Parise, M. E. (2001) · PsycEXTRA Dataset · doi:10.1037/e548252006-001 · Cited by 1,018 · see citing works
Downs, A. M., & de Vincenzi, I. (1996) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199604010-00010 · Cited by 224 · see citing works
Infectiousness of HIV between male homosexual partners
DeGruttola, V. (1989) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(89)90098-x · Cited by 188 · see citing works
Guidelines for the Evaluation of Sexual Abuse of Children: Subject Review
Committee on Child Abuse and Neglect (1999) · PEDIATRICS · doi:10.1542/peds.103.1.186 · Cited by 167 · see citing works
Heppenstall-Heger, A., McConnell, G., Ticson, L., Guerra, L. E., Lister, J., & Zaragoza, T. (2003) · PEDIATRICS · doi:10.1542/peds.112.4.829 · Cited by 148 · see citing works
Shih, C.-C., Kaneshima, H., Rabin, L. B., Namikawa, R., Sager, P., McGowan, J. J., & McCune, J. M. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.3.625 · Cited by 120 · see citing works
Evolution of a Classification Scale: Medical Evaluation of Suspected Child Sexual Abuse
Adams, J. A. (2001) · Child Maltreatment · doi:10.1177/1077559501006001003 · Cited by 101 · see citing works
Wiebe, E. R., Comay, S. E., McGregor, M. J., et al. (2000) · PubMed · Cited by 86 · see citing works
Bassett, I. V., Freedberg, K. A., & Walensky, R. P. (2004) · Clinical Infectious Diseases · doi:10.1086/422459 · Cited by 77 · see citing works
Tolerability and side-effects of post-exposure prophylaxis for HIV infection
Parkin, J. M., Murphy, M., Anderson, J., el-Gadi, S. M., FORSTER, G. E., & Pinching, A. J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05005-9 · Cited by 75 · see citing works
HIV postexposure prophylaxis for children and adolescents
Babl, F. E., Cooper, E. R., Damon, B., et al. (2000) · The American Journal of Emergency Medicine · doi:10.1016/s0735-6757(00)90123-2 · Cited by 60 · see citing works
Human Immunodeficiency Virus Postexposure Prophylaxis for Adolescents and Children
Merchant, R. C., & Keshavarz, R. (2001) · PEDIATRICS · doi:10.1542/peds.108.2.e38 · Cited by 45 · see citing works
Smith, D. G. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-313-4_18 · Cited by 38 · see citing works
Limb, S., Kawsar, M., & FORSTER, G. E. (2002) · International Journal of STD & AIDS · doi:10.1258/09564620260216290 · Cited by 35 · see citing works
Emergency Department Blood or Body Fluid Exposure Evaluations and HIV Postexposure Prophylaxis Usage
Merchant, R. C., Becker, B. M., Mayer, K. H., et al. (2003) · Academic Emergency Medicine · doi:10.1197/s1069-6563(03)00537-2 · Cited by 29 · see citing works
Merchant, R. C., Keshavarz, R., & Low, C. K. (2004) · PubMed · Cited by 24 · see citing works
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
Prospective cohort study of HIV post-exposure prophylaxis for sexual assault survivors.
Loutfy, M. R., Macdonald, S., Myhr, T., Husson, H., Du Mont, J., Balla, S., Antoniou, T., & Rachlis, A. (2008) · Antiviral Therapy · doi:10.1177/135965350801300109 · Cited by 48 · see citing works
Du Mont, J., Myhr, T. L., Husson, H., Macdonald, S., Rachlis, A., & Loutfy, M. R. (2008) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e3181824f3c · Cited by 41 · see citing works
Ford, N., Venter, F., Irvine, C., Beanland, R. L., & Shubber, Z. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ093 · Cited by 38 · see citing works
- Authors
- Neu, N., Heffernan-Vacca, S., Millery, M., Stimell, M., & Brown, J.
- Affiliations
- Columbia University (US)
- Corresponding author
- Neu, Natalie
- Brown, Jocelyn
- Venue
- Sexually Transmitted Diseases
- Published
- 2007-02
- Volume
- 34
- Issue
- 2
- Pages
- 65-68
- ISSN
- 0148-5717 (ISSN-L)
- OpenAlex
- W2029727263
- Cited by
- 32
- References
- 20
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 4 · 2012: 2
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sexually Transmitted Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Health Professions › General Health Professions › Adolescent Sexual and Reproductive Health
- Social Sciences › Gender Studies › Sexual Assault and Victimization Studies
- Keywords
- HIV post-exposure prophylaxis, sexual assault, children and adolescents, zidovudine, lamivudine, medication adherence, adverse events, HIV prevention, emergency department, program feasibility
- MeSH terms
- Adolescent, Adult, Child, Drug Combinations, Female, HIV, Humans, Male, Middle Aged, New York City, Patient Compliance, Prospective Studies, Regression Analysis, Sex Offenses, Zidovudine, HIV Infections, Lamivudine, Anti-HIV Agents
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