HIV postexposure prophylaxis use among Ontario female adolescent sexual assault victims: a prospective analysis.
Abstract
BACKGROUND: This study examined the use of HIV postexposure prophylaxis (PEP) among sexually assaulted adolescent females. METHODS: We analyzed data from the HIV PEP Project, an implementation and evaluation of a program of universal offering of PEP to sexual assault victims of all ages. Baseline and follow-up data were collected prospectively from consecutive clients seen at 18 hospital-based sexual assault treatment centers in Ontario, Canada from September 2003 to January 2005. Among 386 at-risk female adolescents, we examined the provision and uptake of and adherence to PEP, and factors related to antiretroviral acceptance and completion. RESULTS: Most adolescents were single (94.5%), living with family (68.0%), and attending school (67.4%). Slightly over two-fifths (42.7%) accepted and one-third (33.6%) completed the 28-day course of PEP. Factors associated with PEP acceptance were health care provider encouragement, being a student, and being moderately-to-highly anxious. PEP completion was associated with being white and an assailant known less than 24 hours. CONCLUSIONS: Our findings highlight the importance of the health care provider's role in counseling sexually assaulted female adolescents about HIV PEP use. The results also suggest that at-risk adolescents not enrolled in school and those from culturally diverse backgrounds may require additional supports.
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Severe adverse effects are rare from PEP.
“Providers should emphasize that severe adverse effects are rare from PEP (1431–1435).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1432]
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
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- Authors
- Du Mont, J., Myhr, T. L., Husson, H., Macdonald, S., Rachlis, A., & Loutfy, M. R.
- Affiliations
- Women's College Hospital (CA)
- McMaster University (CA)
- University of Toronto (CA)
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Myhr, Terri L.
- Loutfy, Mona R.
- Venue
- Sexually Transmitted Diseases
- Published
- 2008-12
- Volume
- 35
- Issue
- 12
- Pages
- 973-978
- ISSN
- 0148-5717 (ISSN-L)
- OpenAlex
- W142342431
- Cited by
- 41
- References
- 37
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 4
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sexually Transmitted Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Health Professions › General Health Professions › Adolescent Sexual and Reproductive Health
- Social Sciences › Gender Studies › Sexual Assault and Victimization Studies
- Keywords
- HIV post-exposure prophylaxis, sexual assault, adolescent girls, antiretroviral therapy, health professional counseling, anxiety, multicultural communities, Ontario
- MeSH terms
- Adolescent, Adolescent Behavior, Child, Counseling, Female, Humans, Ontario, Patient Compliance, Sex Offenses, Program Evaluation, HIV Infections, Anti-HIV Agents, Crime Victims, Young Adult
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