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The Application of Exposure Therapy and D-Cycloserine to the Treatment of Anorexia Nervosa: A Preliminary Trial
Open accessAbstract
OBJECTIVE: Novel approaches to the treatment of anorexia nervosa (AN) are needed. This preliminary study examined the utility and safety of an exposure therapy intervention and D-cycloserine (DCS) in a population of patients with AN. METHOD: Eleven participants completed a series of 6 laboratory meals, including pre- and post-exposure test meals and four exposure sessions. Participants were randomly assigned to receive either DCS or placebo in double-blind fashion before each of the 4 exposure sessions. These results were compared to data from a previously studied group of patients who received treatment as usual. RESULTS: Total caloric intake increased significantly from the baseline meal session to the post-test meal session in the patients who received the exposure therapy intervention. Caloric intake did not increase significantly in the comparison group. CONCLUSION: These data suggest that an exposure therapy intervention specifically focused on meal consumption may be helpful in increasing intake of a test meal.
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“On the other hand, the current findings add to prior research by showing the potential and success of exposure therapy in the treatment of anorectic fears (e.g. [26, 37, 39, 41–43, 64, 66].”
From Anxiety matters: a pilot lab study into food, weight, and virtual body exposure in anorexia nervosa (2024) · cites this paper as [66]
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Self-citation
Metadata
- Authors
- STEINGLASS, J., SYSKO, R., SCHEBENDACH, J., BROFT, A., STROBER, M., & WALSH, B. T.
- Affiliations
- University of California, Los Angeles (US)
- Rutgers, The State University of New Jersey (US)
- Venue
- Journal of Psychiatric Practice
- Published
- 2007-07
- Volume
- 13
- Issue
- 4
- Pages
- 238-245
- ISSN
- 1527-4160 (ISSN-L)
- 1538-1145
- PMC
- PMC3638255
- OpenAlex
- W2104200966
- Cited by
- 56
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Psychiatric Practice (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH65024, K23MH076195, T32MH15144, R01MH082736, R21MH065024, T32MH015144)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- anorexia nervosa, exposure therapy, D-cycloserine, energy intake, meal ingestion, treatment-resistant eating disorders
- MeSH terms
- Adult, Anorexia Nervosa, Anxiety Disorders, Energy Intake, Combined Modality Therapy, Cycloserine, Desensitization, Psychologic, Double-Blind Method, Eating, Female, Follow-Up Studies, Humans, Pain Measurement, Patient Admission, Body Mass Index, Receptors, N-Methyl-D-Aspartate, Excitatory Amino Acid Agonists
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