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Cited by 230HIV/AIDS Research and InterventionsHIV, Drug Use, Sexual RiskHIV Research and Treatment

Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United States.

Buchbinder, Susan P, Vittinghoff, Eric, Heagerty, Patrick J, Celum, Connie L, Seage, George R, Judson, Franklyn N, McKirnan, David, Mayer, Kenneth H +1 more·2005·JAIDS Journal of Acquired Immune Deficiency Syndromes
DOI 10.1097/01.qai.0000134740.41585.f4
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Abstract

Men who have sex with men (MSM) continue to account for the largest number of new HIV infections in the United States, but limited data exist on independent risk factors for infection beyond the early 1990s. The HIV Network for Prevention Trials Vaccine Preparedness Study enrolled 3257 MSM in 6 US cities from 1995 to 1997. HIV seroincidence was 1.55 per 100 person-years (95% confidence interval: 1.23-1.95) over 18 months of follow-up. On multi-variable analysis using time-dependent covariates, independent risk factors for HIV seroconversion were increased number of reported HIV-negative male sex partners (adjusted odds ratio (AOR) = 1.14 per partner, population attributable risk (PAR) = 28%), nitrite inhalant use (AOR = 2.2, PAR = 28%), unprotected receptive anal sex with an HIV unknown serostatus partner (AOR = 2.7, PAR = 15%) or HIV-positive partner (AOR = 3.4, PAR = 12%), protected receptive anal sex with an HIV-positive partner (AOR = 2.2, PAR = 11%), lack of circumcision (AOR = 2.0, PAR = 10%), and receptive oral sex to ejaculation with an HIV-positive partner (AOR = 3.8, PAR = 7%). Having a large number of male sex partners, nitrite inhalant use, and engaging in receptive anal sex explained the majority of infections in this cohort and should be targeted in prevention strategies for MSM.

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Crossref · 10.1097/01.qai.0000134740.41585.f4

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  • MSM might be at increased risk for HIV and other STIs because of their sexual network or behavioral or biologic factors, including number of concurrent partners, condomless sex, anal sex, or substance use.

    “MSM might be at increased risk for HIV and other STIs because of their sexual network or behavioral or biologic factors, including number of concurrent partners, condomless sex, anal sex, or substance use (180–182).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [180]

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Authors
Buchbinder, S. P., Vittinghoff, E., Heagerty, P. J., Celum, C. L., Seage, G. R., Judson, F. N., McKirnan, D., Mayer, K. H., & Koblin, B. A.
Affiliations
  • University of California, San Francisco (US)
  • University of Washington (US)
  • Harvard University (US)
  • New York Blood Center (US)
  • Brown University (US)
Corresponding author
  • Buchbinder, Susan P
  • Mayer, Kenneth H
ORCID
Venue
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-05-01
Volume
39
Issue
1
Pages
82-89
ISSN
1525-4135 (ISSN-L)
DOI
10.1097/01.qai.0000134740.41585.f4
OpenAlex
W2049025370
Cited by
230
References
64
Citations by year
2026: 2 · 2024: 5 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 13 · 2014: 15 · 2013: 23 · 2012: 11
FWCI
13.22
Type
journal article
Language
en
Open access
closed
Locations
  • JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01ai045200-020, n01ai035176-021)
  • Centers for Disease Control and Prevention
  • National Institute of Allergy and Infectious Diseases (5 U01 AI479950, P30AI027742, N01 AI 35176, AI27742, N01 AI45200)
  • National Center for Research Resources (M01 RR 00096, M01RR000096)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
HIV seroconversion, men who have sex with men, HIV risk factors, male circumcision, sexual partners, receptive anal intercourse, unprotected sex, oral sex, HIV prevention
MeSH terms
Administration, Inhalation, Adult, Circumcision, Male, Educational Status, Ethnicity, HIV Seropositivity, Humans, Male, Nitrites, Regression Analysis, Risk Factors, Risk-Taking, Sexual Behavior, United States, Homosexuality, Male

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