The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Relaxivity of Gadopentetate Dimeglumine (Magnevist), Gadobutrol (Gadovist), and Gadobenate Dimeglumine (MultiHance) in Human Blood Plasma at 0.2, 1.5, and 3 Tesla
Abstract
OBJECTIVES: We sought to determine the relaxivity and accurate relaxation rates of Gd-DTPA, Gd-BT-DO3A, and Gd-BOPTA at 0.2, 1.5, and 3 T in human blood plasma. MATERIALS AND METHODS: Contrast media concentrations between 0.01 and 16 mM in human plasma were used for relaxation measurements. The R1 and R2 relaxation rates and r1 and r2 relaxivities were determined. RESULTS: Gd-BOPTA produced the highest relaxation rates and relaxivities at all field strengths. The r1 and r2 values for Gd-BOPTA were 107-131% and 91-244% higher than for Gd-DTPA, respectively, and 72-98% and 82-166% higher than for Gd-BT-DO3A. Higher field strengths resulted in lower values of R1, R2, and r1 for all contrast agents tested and of r2 for Gd-DTPA and Gd-BT-DO3A. A linear dependence of R1 and R2 on concentration was found for Gd-DTPA and Gd-BT-DO3A and a nonlinear dependence for Gd-BOPTA for concentrations larger than 1 mM. The r1 and r2 relaxivity of Gd-BOPTA increased with decreasing concentration. CONCLUSIONS: Gd-BOPTA demonstrates the highest longitudinal r1 at all field strengths, which is ascribable to weak protein interaction. The R2/R1 ratio increases at higher field strength only for Gd-BOPTA, hence very short echo times are required for Gd-BOPTA to benefit from the higher longitudinal relaxivity.
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Metadata
- Authors
- Pintaske, J., Martirosian, P., Graf, H., Erb, G., Lodemann, K.-P., Claussen, C. D., & Schick, F.
- Venue
- Investigative Radiology
- Published
- 2006-03
- Volume
- 41
- Issue
- 3
- Pages
- 213-221
- ISSN
- 0020-9996 (ISSN-L)
- OpenAlex
- W2058710711
- Cited by
- 383
- References
- 14
- FWCI
- 18.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pintaske, J., Martirosian, P., Graf, H., Erb, G., Lodemann, K.-P., Claussen, C. D., & Schick, F. (2006). Relaxivity of Gadopentetate Dimeglumine (Magnevist), Gadobutrol (Gadovist), and Gadobenate Dimeglumine (MultiHance) in Human Blood Plasma at 0.2, 1.5, and 3 Tesla. Investigative Radiology. https://doi.org/10.1097/01.rli.0000197668.44926.f7
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