The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Comparative efficacy of ropivacaine and bupivacaine infiltrative analgesia in otoplasty.
Abstract
In Brief A prospective double-blind study was conducted to compare the anesthetic efficacy of ropivacaine and bupivacaine in a bilaterally symmetrical otoplasty model. Because ropivacaine has a significantly lower toxic potential than bupivacaine, it may be established as the anesthetic agent of choice for low-dose infiltration anesthesia in routine aesthetic facial operations. Each of the 24 adult patients undergoing bilateral otoplasty received infiltration with ropivacaine in 1 auricle and an equal volume of bupivacaine in the other. Patients were requested to assess their pain separately in each side at the times of infiltration, during cartilage scoring, and 2, 6, and 10 hours postoperatively on a visual analog scale. Intraoperative success rates were similar, and overall analgesia achieved at 2 hours, 6 hours, and 10 hours postoperatively was not found to be statistically different between ropivacaine and bupivacaine. The authors conclude that ropivacaine can be used as an effective alternative to bupivacaine in otoplasty. In a double-blind study of 24 adult bilateral otoplasties, infiltration anesthesia was achieved with ropivacaine in one ear and bupivacaine in the other. There was no difference in pain perception intraoperatively or at 2, 6, and 10 hours postoperatively.
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In bilateral cases, bupivacaine and ropivacaine had similar analgesic efficacy.
“In bilateral cases, Kakagia et al20 found similar analgesic efficacy for bupivacaine and ropivacaine but highlighted ropivacaine’s lower cardiotoxicity, making it preferable in high-risk patients.20”
From Perioperative Analgesia and Postoperative Nausea and Vomiting Management in Otoplasty: A Systematic Review (2026) · cites this paper as [20]
Ropivacaine has lower cardiotoxicity than bupivacaine, making it preferable in high-risk patients.
“In bilateral cases, Kakagia et al20 found similar analgesic efficacy for bupivacaine and ropivacaine but highlighted ropivacaine’s lower cardiotoxicity, making it preferable in high-risk patients.20”
From Perioperative Analgesia and Postoperative Nausea and Vomiting Management in Otoplasty: A Systematic Review (2026) · cites this paper as [20]
Lidocaine-based local infiltration provides useful intraoperative analgesia, yet is consistently inferior to regional nerve block at 6-12 hours postoperatively.
“The present synthesis also clarifies that lidocaine-based local infiltration (1% with adrenaline 1:200,000) provides useful intraoperative analgesia, yet is consistently inferior to RNB at 6–12 hours postoperatively—an interval in which bupivacaine RNB still confers sensory blockade, opioid-sparing, and higher comfort scores.20”
From Perioperative Analgesia and Postoperative Nausea and Vomiting Management in Otoplasty: A Systematic Review (2026) · cites this paper as [20]
Citations
Cites
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Acute Toxicity of Ropivacaine Compared with That of Bupivacaine
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Disposition Kinetics of Ropivacaine in Humans
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Research works printed but not linked: 4
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Cited by
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Alnufaei, A. H., AlSubaie, F. K., Aljabri, R. A., Aloqayli, S. Z., Alanshmi, S., Alotaibi, S. M., Ajeeb, Z. B., AlGhamdi, L. Y., Kattan, M. E., Alahmadi, B. H., et al. (2026) · Plastic and Reconstructive Surgery - Global Open · doi:10.1097/gox.0000000000007347
Metadata
- Authors
- Kakagia, D., Fotiadis, S., & Tripsiannis, G.
- Affiliations
- Democritus University of Thrace (GR)
- Corresponding author
- Kakagia, Despoina
- ORCID
- Kakagia, Despoina
- Venue
- Annals of Plastic Surgery
- Published
- 2005-04
- Volume
- 54
- Issue
- 4
- Pages
- 409-411
- ISSN
- 0148-7043 (ISSN-L)
- OpenAlex
- W2044515233
- Cited by
- 15
- References
- 13
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Plastic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Health Sciences › Medicine › Surgery › Reconstructive Facial Surgery Techniques
- Health Sciences › Dentistry › Oral Surgery › Dental Anxiety and Anesthesia Techniques
- Keywords
- ropivacaine, bupivacaine, otoplasty, local infiltration anesthesia, postoperative analgesia, local anesthetic efficacy, auricle, pain perception, facial aesthetic surgery
- MeSH terms
- Ropivacaine, Adult, Amides, Anesthetics, Local, Bupivacaine, Double-Blind Method, Ear, Female, Humans, Male, Prospective Studies, Plastic Surgery Procedures
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